Abstract: A blood pressure measuring device includes a main body and an airbag. An air supply and exhaust apparatus and a first air pressure sensor may be disposed in the cavity of the main body. The air supply and exhaust apparatus includes an air inlet passage and an air outlet passage. The air supply and exhaust apparatus is communicated with the air cavity through a first air passage. The first air pressure sensor includes a first air hole and a second air hole, and a pressure film is provided between the first air hole and the second air hole. A first vent hole is provided on the side wall of the main body. The first air hole may be communicated with the air cavity of the airbag through a second air passage, and the second air hole may be communicated with the first vent hole through a third air passage.

Abstract: A wearable device and an airbag preparation method. The wearable device includes a watch body, an airbag, and an airbag cover. The airbag is detachably connected to an end of the watch body, so that a coverage area of the airbag for the watch body is small, thereby reserving space for installing another module on the watch body. The airbag includes a first layer structure and a second layer structure that are superposed. The first layer structure has a first cavity, the second layer structure has a second cavity, and the first cavity communicates with the second cavity.

Abstract: The present application discloses a thermal insulation coating and a method for applying the same. Raw materials for preparing the thermal insulation coating includes PVDF resin, water-based epoxy resin solution, hollow glass microbead, ytterbium modified nano-powder, diluent, polyvinyl alcohol, titanium dioxide powder, rare earth, negative ion powder, and leveling agent.

Abstract: A microchip with flow-through inlet (104) and outlet (106) channels and test channels (108). The test channels (108) are in fluid communication with the inlet (104) and outlet (106) channels, through inlets (114) and outlets (116) respectively. Each test channel (108) has one test site therein for detection of specific molecules or molecular interactions. The inlet (114) in a test channel (108) is elevated from the outlet (116) of the test channel (108) and the outlet (116) is elevated from a fluid level (124) in the outlet channel (106). Back diffusion from outlet channel (106) to the test channels (108) and from the test channels (108) to the inlet channel (104) can thus be inhibited to reduce or eliminate cross-interference between different test sites. The microchip can be useful as a flow-through high density enzyme immunoassay array device with high-throughput.

Abstract: A new battery type super capacitor electrode material having high power density and high energy density is provided. The electrode material is made from multi-layer of Bi2S3/CNT films and rGO films, wherein the layer number of Bi2S3/CNT films is same as the layer number of rGO films, and the Bi2S3/CNT films and rGO films are alternately stacked on top of each other. Further, a method of preparing an electrode material is provided. The methods includes coating Bi2S3/CNT and drying; depositing graphene oxide onto Bi2S3/CNT via electrochemical deposition; and, reducing graphene oxide to rGO by cyclic voltammetry to obtain a product. The capacitor electrode material has high energy density (460 Wh/kg), high power density (22802 W/kg) and specific capacitance (specific capacitance of 3568 F/g when current density is 22 A/g), and excellent cycling stability (remaining 90% of initial capacity after 1000 cycles).

Abstract: The present invention refers to a droplet-based miniaturized device with on-demand droplet-trapping, -fusion, and -releasing. The device makes use of different electrical fields for directing droplets into microwells and releasing them from the same. In another aspect, the present invention refers to a system comprising such a microfluidic device and a method of operating it.

Abstract: The present invention refers to a method of manufacturing a micro patterned device. The method can comprise or consist of applying a light curable epoxy resin to a mold to obtain a curable resin filled mold. In a further step a polymeric film or an epoxy resin-coated glass is applied over the curable resin filled mold. Subsequently, the curable resin filled mold to which the polymeric film or the epoxy resin-coated glass is applied is irradiated to cure the resin. In another aspect the present invention refers to a micro patterned device obtained by a method described herein.

Abstract: A bioelectronic microchip formed on a substrate (16) includes a plurality of field effect transistors (10), each including first (12) and second (14) electrodes on the substrate; and a channel (18) extending between the first and second electrodes. An organic semiconducting material fills the channel (18); and a dielectric layer (20) formed atop the first and second electrodes and the channel. An electrolyte (22) to hold a probe molecule may be formed on the dielectric. A third electrode (24) in proximity with the first and second electrodes and isolated therefrom contacts the dielectric. Capture of target molecules may be detected at each transistor through changes in source to drain characteristics. The method provides high density and low cost sensors, particularly in diagonistic and drug discovery applications.

Abstract: Addressable bio/chem chips include a plurality of isolated test cells, each addressable by at least two electrodes for measuring electrical characteristics of probe/test molecule interactions. In one embodiment, electrodes are located within a channel to allow for four terminal measurement. In another embodiment, electrodes are arranged in rows and columns and interconnected with electrolyte pads used as test sites. In yet another embodiment, electrodes are arranged in cells, with each cell including a counter electrode surrounded encircled by working electrodes.

Abstract: The present invention refers to a droplet-based miniaturized device with on-demand droplet-trapping, -fusion, and -releasing. The device makes use of different electrical fields for directing droplets into microwells and releasing them from the same. In another aspect, the present invention refers to a system comprising such a microfluidic device and a method of operating it.

Abstract: A molecular detection device for use in electrochemical detection assays includes at least two electrodes, and has a film deposited on at least one of the electrodes. The film includes a conductive polymer and conductive particles, having mean diameters between 1 and 100 nm, within the conductive polymer. Probe molecules may be attached on or to the conductive polymer, or be included in the conductive polymer. The device may be used to detect specific target molecules in a sample, for example, protein, peptide, nucleic acid or small molecule target molecules.

Abstract: The present invention refers to a method of manufacturing a micro patterned device. The method can comprise or consist of applying a light curable epoxy resin to a mold to obtain a curable resin filled mold. In a further step a polymeric film or an epoxy resin-coated glass is applied over the curable resin filled mold. Subsequently, the curable resin filled mold to which the polymeric film or the epoxy resin-coated glass is applied is irradiated to cure the resin. In another aspect the present invention refers to a micro patterned device obtained by a method described herein.

Abstract: The present invention refers to a flow-through method of functionalizing an inner surface of a microfluidic device. The method can comprise transporting a silanizing solution through the microfluidic device to silanize the inner surface of the microfluidic device. The method can further comprise reacting the silanized surface with an oxidized polysaccharide to bind the oxidized polysaccharide to the silanized surface by transporting the oxidized polysaccharide through the microfluidic device. The present invention also refers to a microfluidic device which has been subjected to a flow-through method of the present invention so that at least a part of the inner surface or the entire inner surface of the microfluidic device is functionalized.

Abstract: A microchip with flow-through inlet (104) and outlet (106) channels and test channels (108). The test channels (108) are in fluid communication with the inlet (104) and outlet (106) channels, through inlets (114) and outlets (116) respectively. Each test channel (108) has one test site therein for detection of specific molecules or molecular interactions. The inlet (114) in a test channel (108) is elevated from the outlet (116) of the test channel (108) and the outlet (116) is elevated from a fluid level (124) in the outlet channel (106). Back diffusion from outlet channel (106) to the test channels (108) and from the test channels (108) to the inlet channel (104) can thus be inhibited to reduce or eliminate cross-interference between different test sites. The microchip can be useful as a flow-through high density enzyme immunoassay array device with high-throughput.

Abstract: A bioelectronic microchip formed on a substrate (16) includes a plurality of field effect transistors (10), each including first (12) and second (14) electrodes on the substrate; and a channel (18) extending between the first and second electrodes. An organic semiconducting material fills the channel (18); and a dielectric layer (20) formed atop the first and second electrodes and the channel. An electrolyte (22) to hold a probe molecule may be formed on the dielectric. A third electrode (24) in proximity with the first and second electrodes and isolated therefrom contacts the dielectric. Capture of target molecules may be detected at each transistor through changes in source to drain characteristics. The method provides high density and low cost sensors, particularly in diagonistic and drug discovery applications.

Abstract: A molecular detection device for use in electrochemical detection assays includes at least two electrodes, and has a film deposited on at least one of the electrodes. The film includes a conductive polymer and conductive particles, having mean diameters between 1 and 100 nm, within the conductive polymer. Probe molecules may be attached on or to the conductive polymer, or be included in the conductive polymer. The device may be used to detect specific target molecules in a sample, for example, protein, peptide, nucleic acid or small molecule target molecules.

Abstract: This invention relates to methods and compositions for determining single nucleotide polymorphisms (SNPs) in P450 genes. In preferred embodiments, self extension of interrogation probes is prevented by using novel non self-extension probes and/or methods, thereby improving the specificity and efficiency of P450 SNP detection in target samples with minimal false positive results. The invention thus describes a variety of methods to decrease self-extension of interrogation probes. In addition, this invention provides a unique collection of P450 SNP probes on one assay, primer sequences for specific amplification of each of the seven P450 genes and amplicon control probes to evaluate whether the intended p450 gene targets were amplified successfully. The invention also describes a variety of array platforms for performing the assays of the invention; for example: CodeLink™, eSensor™, multiplex arrays with cartridges etc., all described herein.

Abstract: Addressable bio/chem chips include a plurality of isolated test cells, each addressable by at least two electrodes for measuring electrical characteristics of probe/test molecule interactions. In one embodiment, electrodes are located within a channel to allow for four terminal measurement. In another embodiment, electrodes are arranged in rows and columns and interconnected with electrolyte pads used as test sites. In yet another embodiment, electrodes are arranged in cells, with each cell including a counter electrode surrounded encircled by working electrodes.

Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.

Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.