Abstract: The present invention relates to salt forms of the Pim kinase inhibitor N—{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of Pim kinase-related diseases such as cancer.

Abstract: A method for extracting pullulan polysaccharide from high-viscosity fermentation broth includes following steps: (1) removing cells from the fermentation broth; (2) removing proteins; (3) decolorizing by macroporous resin adsorption; (4) removing ions by ultrafiltration; and (5) drying, crushing and packaging. In the extraction method of the present application, by using natural polymer bioflocculant chitosan, the high-viscosity fermentation broth can be processed without dilution and addition of filter aids and organic solvents for alcohol precipitation, which reduces the pressure of subsequent decolorization, properly recycles the cell proteins, and avoids the potential hazard of the organic solvents. The method can obtain high-purity pullulan polysaccharide, improving the product yield and quality, reducing solid waste, reducing the production cost, and achieving a safe, efficient, continuous and automated production process.

Abstract: A method for extracting pullulan polysaccharide from high-viscosity fermentation broth includes following steps: (1) removing cells from the fermentation broth; (2) removing proteins; (3) decolorizing by macroporous resin adsorption; (4) removing ions by ultrafiltration; and (5) drying, crushing and packaging. In the extraction method of the present application, by using natural polymer bioflocculant chitosan, the high-viscosity fermentation broth can be processed without dilution and addition of filter aids and organic solvents for alcohol precipitation, which reduces the pressure of subsequent decolorization, properly recycles the cell proteins, and avoids the potential hazard of the organic solvents. The method can obtain high-purity pullulan polysaccharide, improving the product yield and quality, reducing solid waste, reducing the production cost, and achieving a safe, efficient, continuous and automated production process.

Abstract: A color sorting method for small-grain agricultural products combining an area scanning photoelectric characteristic and a line scanning photoelectric characteristic is provided. The present invention obtains an area scan image of small-grain agricultural product materials on a conveyor belt by using an area scan camera, which can accurately extract area array features of the materials and realize accurate identification of the unqualified materials. At the same time, the present invention can provide key parameters for accurate positioning during free falling of the materials while identifying the unqualified materials by using the area scan image, and can cooperate with the line scan positioning camera and the pneumatic nozzle to achieve high-speed elimination of the unqualified materials.

Abstract: A color sorting method for small-grain agricultural products combining an area scanning photoelectric characteristic and a line scanning photoelectric characteristic is provided. The present invention obtains an area scan image of small-grain agricultural product materials on a conveyor belt by using an area scan camera, which can accurately extract area array features of the materials and realize accurate identification of the unqualified materials. At the same time, the present invention can provide key parameters for accurate positioning during free falling of the materials while identifying the unqualified materials by using the area scan image, and can cooperate with the line scan positioning camera and the pneumatic nozzle to achieve high-speed elimination of the unqualified materials.