Patents by Inventor Changsheng Zheng

Changsheng Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
    Patent number: 7307086
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: December 11, 2007
    Assignee: Incyte Corporation
    Inventors: Chu-Biao Xue, Changsheng Zheng, Ganfeng Cao, Hao Feng, Michael Xia, Rajan Anand, Joseph Glenn, Brian W. Metcalf
  • 3-Aminopyrrolidine derivaties as modulators of chemokine receptors
    Publication number: 20060252751
    Abstract: The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
    Type: Application
    Filed: November 26, 2003
    Publication date: November 9, 2006
    Inventors: Chu-Biao Xue, Brian Metcalf, Hao Feng, Ganfeng Cao, Taisheng Huang, Changsheng Zheng, Darius Robinson
  • 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
    Publication number: 20060020133
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
    Type: Application
    Filed: June 27, 2005
    Publication date: January 26, 2006
    Inventors: Chu-Biao Xue, Changsheng Zheng, Hao Feng, Michael Xia, Joseph Glenn, Ganfeng Cao, Brian Metcalf
  • Piperidine amides as modulators of chemokine receptor activity
    Patent number: 6984651
    Abstract: The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: January 10, 2006
    Assignee: Bristol-Myers Squibb Pharma, Company
    Inventors: John V. Duncia, Joseph B. Santella, Dean A. Wacker, Wenqing Yao, Changsheng Zheng
  • 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
    Publication number: 20060004018
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
    Type: Application
    Filed: June 27, 2005
    Publication date: January 5, 2006
    Inventors: Chu-Biao Xue, Changsheng Zheng, Hao Feng, Michael Xia, Joseph Glenn, Ganfeng. Cao, Brian Metcalf
  • 3-(4-Heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
    Publication number: 20050267146
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
    Type: Application
    Filed: May 10, 2005
    Publication date: December 1, 2005
    Inventors: Chu-Biao Xue, Changsheng Zheng, Ganfeng Cao, Hao Feng, Michael Xia, Rajan Anand, Joseph Glenn, Brian Metcalf
  • 3-Cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
    Publication number: 20050192302
    Abstract: The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
    Type: Application
    Filed: December 16, 2004
    Publication date: September 1, 2005
    Inventors: Chu-Biao Xue, Brian Metcalf, Amy Han, Darius Robinson, Changsheng Zheng, Anlai Wang, Yingxin Zhang
  • N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
    Patent number: 6919368
    Abstract: The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: July 19, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Soo S. Ko, George V. Delucca, John V. Duncia, Ui Tae Kim, Dean A. Wacker, Changsheng Zheng
  • Piperidine amides as modulators of chemokine receptor activity
    Publication number: 20040082790
    Abstract: The present application describes modulators of CCR3 of formula (I): 1
    Type: Application
    Filed: August 7, 2003
    Publication date: April 29, 2004
    Inventors: John V. Duncia, Joseph B. Santella, Dean A. Wacker, Wenqing Yao, Changsheng Zheng
  • N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
    Publication number: 20040034063
    Abstract: The present application describes modulators of CCR3 of formula (I): 1
    Type: Application
    Filed: February 6, 2003
    Publication date: February 19, 2004
    Inventors: Soo S. Ko, George V. Delucca, John V. Duncia, Ui Tae Kim, Dean A. Wacker, Changsheng Zheng
  • Piperidine amides as modulators of chemokine receptor activity
    Patent number: 6638950
    Abstract: The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: October 28, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John V. Duncia, Joseph B. Santella, Dean A. Wacker, Wenqing Yao, Changsheng Zheng
  • N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
    Patent number: 6525069
    Abstract: The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: February 25, 2003
    Assignee: Bristol-Myers Squibb Pharma Co.
    Inventors: Soo S. Ko, George V. Delucca, John V. Duncia, Ui Tae Kim, Dean A. Wacker, Changsheng Zheng
  • Piperidine amides as modulators of chemo kine receptor activity
    Publication number: 20020156102
    Abstract: The present application describes modulators of CCR3 of formula (I): 1
    Type: Application
    Filed: June 20, 2001
    Publication date: October 24, 2002
    Inventors: John V. Duncia, Joseph B. Santella, Dean A. Wacker, Wenqing Yao, Changsheng Zheng