Patents by Inventor Changshui Xu

Changshui Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Application of puerarin in the preparation of P2Xmediated drugs for pain/nervous system diseases
    Patent number: 8362070
    Abstract: The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: January 29, 2013
    Assignee: Nanchang University
    Inventors: Shangdong Liang, Changshui Xu, Yun Gao, Guilin Li, Jiari Lin, Shuangmei Liu, Han Liu, Jun Zhang, Xin Li
  • APPLICATION OF PUERARIN IN THE PREPARATION OF P2X3 MEDIATED DRUGS FOR PAIN/NERVOUS SYSTEM DISEASES
    Publication number: 20110152205
    Abstract: The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain.
    Type: Application
    Filed: June 29, 2010
    Publication date: June 23, 2011
    Applicant: Nanchang University
    Inventors: Shangdong Liang, Changshui Xu, Yun Gao, Guilin Li, Jiari Lin, Shuangmei Liu, Han Liu, Jun Zhang, Xin Li