Abstract: The present disclosure relates to a ligand-drug conjugate of a novel structure or a pharmaceutically acceptable salt thereof. Specifically, the present disclosure provides a ligand-drug conjugate having a structural general formula represented by Pc-(L-D)n or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising the conjugate, and use thereof in treating a tumor.

Abstract: The present application discloses a detection circuit and a power management system including the detection circuit. The detection circuits include a threshold voltage generation circuit, a voltage-to-current conversion circuit, and a current-type successive approximation quantizer. The voltage-to-current conversion circuit converts an offset voltage of a signal to be detected into a proportional current with respect to a threshold voltage which is generated by the threshold voltage generation circuit. The current-type successive approximation quantizer obtains a comparison result between the signal to be detected and the threshold voltage, or a quantization result of the signal to be detected within a window by quantizing the proportional current. Thus, the circuit structure is simplified and the cost is reduced.