Patents by Inventor Changyang LINGHU

Changyang LINGHU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for simultaneous measurement of multiple biological signals from spectrally identical fluorescent reporters
    Patent number: 11782064
    Abstract: The invention, in some aspects, relates to the preparation and use of signaling reporter islands (SiRIs) in single cells. Compositions of the invention that produce SiRIs can be delivered to a cell resulting in the presence of one or more SiRIs in the cell. Methods of the invention include detecting signals generated by elements in the SiRIs in a cell and use of the detected signals to determine and analyze simultaneous physiological processes within the cell, or cells.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: October 10, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Changyang Linghu, Shannon L. Johnson, Edward Stuart Boyden
  • INTRACELLULAR MOLECULAR RECORDING AND MEMORY VIA PROTEIN SELF-ASSEMBLY
    Publication number: 20230250139
    Abstract: The invention, in some aspects, includes compositions encoding expression-recording islands (XRIs), compositions comprising XRIs, and methods for using XRIs for intracellular molecular recording.
    Type: Application
    Filed: October 11, 2022
    Publication date: August 10, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Changyang Linghu, Edward S. Boyden
  • Somatic opsins for single cell resolution optogenetics
    Patent number: 11324824
    Abstract: The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to target opsins to the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.
    Type: Grant
    Filed: June 3, 2017
    Date of Patent: May 10, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Or A. Shemesh, Changyang Linghu, Edward Boyden
  • Cell Body Targeted Sensors
    Publication number: 20220048970
    Abstract: The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to direct and localize sensor molecules in the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to determine activity in cells in which they are expressed.
    Type: Application
    Filed: December 11, 2019
    Publication date: February 17, 2022
    Inventors: Or A. Shemesh, Changyang Linghu, Kiryl D. Piatkevich, Edward S. Boyden, Won Min Park
  • METHODS FOR SIMULTANEOUS MEASUREMENT OF MULTIPLE BIOLOGICAL SIGNALS FROM SPECTRALLY IDENTICAL FLUORESCENT REPORTERS
    Publication number: 20210080472
    Abstract: The invention, in some aspects, relates to the preparation and use of signaling reporter islands (SiRIs) in single cells. Compositions of the invention that produce SiRIs can be delivered to a cell resulting in the presence of one or more SiRIs in the cell. Methods of the invention include detecting signals generated by elements in the SiRIs in a cell and use of the detected signals to determine and analyze simultaneous physiological processes within the cell, or cells.
    Type: Application
    Filed: September 14, 2020
    Publication date: March 18, 2021
    Inventors: Changyang Linghu, Shannon L. Johnson, Edward Stuart Boyden
  • SOMATIC OPSINS FOR SINGLE CELL RESOLUTION OPTOGENETICS
    Publication number: 20190307882
    Abstract: The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to target opsins to the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.
    Type: Application
    Filed: June 3, 2017
    Publication date: October 10, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Or A. SHEMESH, Changyang LINGHU, Edward BOYDEN