Abstract: The present disclosure is directed to peptide immunogen constructs targeting portions of Calcitonin Gene-Related Peptide (CGRP), compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions thereof. The disclosed peptide immunogen constructs have more than about 30 amino acids and contain (a) a B cell epitope having about more than about 7 contiguous amino acid residues from the CGRP receptor binding or activation regions of the full-length CGRP protein; (b) a heterologous Th epitope; and (c) an optional heterologous spacer. The disclosed CGRP peptide immunogen constructs stimulate the generation of highly specific antibodies directed CGRP for the prevention and/or treatment of migraine.

Abstract: The present invention relates to a baccarat game system capable of screening games and a game screening method thereof. After at least one player respectively selects any one of at least one screening rule by means of a screening selection button, a screening device screens out a baccarat game meeting the screening rule, and a display element corresponding to the at least one player displays a historical game record of the baccarat game meeting the screening rule; after the at least one player places a bet on the selected baccarat game by means of a plurality of betting buttons and a new game result is generated, a payment processing unit pays for the at least one player. In this way, the at least one player can be assisted to place a bet, so that the betting efficiency is improved, thereby improving the billing.

Abstract: A bet display system for roulette includes a game processing unit, a game result generating unit, a betting interface, and a game status display screen. The game result generating units generates one of game results. The betting interface is provided for a player to bet to generate a betting data. The game status display screen displays bars which show substantial betting points of the game results equivalently converted from the betting data through different length. The game processing unit performs a numerical range classification on numerical values of the substantial betting points, the substantial betting points are arranged from small to large numerical values and classified to belong to range groups Pi, wherein i is one of 1, 2, . . . , N, N is greater than or equal to 3, and the substantial betting point belonging to the range group PN is shown by the bar with the longest length.

Abstract: A betting amount proportion display system for roulette calculates and obtains a substantial betting point of game results respectively through a game processing unit, and performs a numerical range classification on numerical values of the points of the game results, so that the points are arranged from small to large numerical values and classified to belong to range groups Pi, i=one of 1, 2, . . . , N, N is greater than or equal to 3. The roulette image displays the game results arranged in a ring, and the roulette image displays bars at positions adjacent to the game results, the bars correspondingly show the points of the adjacent game results, so that betting amounts of the points are displayed proportionally, a length of each bar correspondingly shows the range group Pi, i=1, 2, . . . , N the points are classified to belong to.

Abstract: The present invention discloses a game system capable of autonomously determining to change the betting time, including at least one betting interface, at least one player operation element, at least one display element, a game result generation unit, a payout unit and a game processing unit, wherein the game processing unit initiates the at least one betting interface within a specified period of time, allowing the at least one player to place bets on the at least one betting interface via the at least one player operation element, and the game processing unit determines whether a game progression in a current round-based game meets a specified condition in the specified period of time by the game processing unit. If the specified condition is met, the game processing unit changes a duration of the specified period of time based on a specified setting.

Abstract: The invention provides a game system capable of maintaining gameplay continuity for a player, including an operation element, a game processing element, and a display device. The game processing unit allows a player to operate to play the slot game and generate a primary game process, and produces a main real-time game image associated with the slot game based on the primary game process. When a reward game is triggered, the game processing unit initiates a sub-game process to generate a sub real-time game image associated with the reward game. The main and sub real-time game images are generated simultaneously. The display device includes a main display area displaying the main real-time game image and at least one sub display area displaying the sub real-time game image. This allows the main and sub real-time game images to be displayed simultaneously, ensuring that the primary game process continues without interruption.

Abstract: The present disclosure is directed to peptide immunogen constructs targeting the extracellular membrane-proximal domain of membrane-bound IgE (or IgE EMPD) and formulations thereof for the treatment of IgE-mediated allergic diseases. The IgE EMPD peptide immunogen constructs have a B cell epitope peptide of more than 20 amino acids, preferably cyclic, linked through an optional spacer to heterologous T helper cell (Th) epitopes derived from pathogen proteins. These peptide immunogen constructs and formulations thereof can stimulate the generation of highly specific antibodies in vaccinated hosts that are directed against the IgE EMPD peptide and are crossreactive with membrane-bound IgE on B lymphocytes committed to IgE secretion.

Abstract: The present invention is directed to novel heterologous promiscuous and artificial T helper cell epitopes (Th epitopes) designed to provide optimum immunogenicity of a target antigenic site. The disclosed Th epitopes, when covalently linked to a B cell epitope in a peptide immunogen construct, elicit a strong antibody response to the B cell epitope of the target antigenic site. The Th epitopes are immunosilent on their own, i.e., little, if any, of the antibodies generated by the peptide immunogen constructs will be directed towards the Th epitope, thus allowing a very focused immune response directed to the targeted antigenic site. The heterologous promiscuous Th epitopes provide effective and safe peptide immunogens that do not generate inflammatory, anti-self, cell-mediated immune responses following administration.

Abstract: The present invention generates at least one set of variable odds for at least one payout odds of a game result by an odds processing unit. The number of the variable odds are more than two, and one of the variable odds replaces the corresponding payout odds. The numerical values of parts of the variable odds are lower than the numerical values of the corresponding payout odds. By lowering the numerical values of some of the variable odds, the numerical values of the others of the variable odds can be increased, thereby ensuring that a maximum possible value of the variable odds is attractive enough to players. Additionally, an image synthesis processing unit is provided for generating a synthesized image. By displaying the synthesized image, an immersive experience is enhanced.

Abstract: The present invention relates to a game system capable of determining use time. Any one of a plurality of props is generated by a game result generation unit according to a probability, and a storage unit is caused to record any one of the generated props, or a member management unit is caused to select, according to a consumption record and a given rule, at least one of the plurality of props to be stored into a piece of account data, and the prop recorded in the account data is transferred to the storage unit, the plurality of props each having a specified game effect; moreover, when a control unit determines that a player uses at least one prop recorded in the storage unit, a corresponding specified game effect will be generated, and the used prop is deleted from the storage unit.

Abstract: The present disclosure is directed to individual peptide immunogen constructs targeting portions of the Interleukin-6 (IL-6) protein, compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions thereof. The disclosed IL-6 peptide immunogen constructs contain a B cell epitope from IL-6 linked to a heterologous T helper cell (Th) epitope directly or through an optional heterologous spacer. The IL-6 peptide immunogen constructs stimulate the generation of highly specific antibodies directed to the IL-6 receptor (IL-6R) binding site for the prevention and/or treatment of diseases impacted by IL-6 dysregulation.

Abstract: The present invention generates at least one set of variable odds for at least one payout odds of a game result by an odds processing unit. The number of the variable odds are more than two, and one of the variable odds replaces the corresponding payout odds. The numerical values of parts of the variable odds are lower than the numerical values of the corresponding payout odds. By lowering the numerical values of some of the variable odds, the numerical values of the others of the variable odds can be increased, thereby ensuring that a maximum possible value of the variable odds is attractive enough to players. Additionally, an image synthesis processing unit is provided for generating a synthesized image. By displaying the synthesized image, an immersive experience is enhanced.

Abstract: The present disclosure is directed to peptide immunogen constructs targeting portions of Islet Amyloid Polypeptide (IAPP), compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions thereof. The disclosed peptide immunogen constructs have more than about 30 amino acids and contain (a) a B cell epitope having about more than about 6 contiguous amino acid residues from the IAPP aggregation prone region of the full-length IAPP protein; (b) a heterologous Th epitope; and (c) an optional heterologous spacer. The disclosed IAPP peptide immunogen constructs stimulate the generation of highly specific antibodies directed IAPP for the prevention and/or treatment of disorders associated with aggregated IAPP.

Abstract: The present disclosure is directed to individual peptide immunogen constructs targeting portions of the Tau protein for the treatment and/or prevention of tauopathies. The present disclosure is also directed to compositions containing the peptide immunogen constructs, methods of making and using the peptide immunogen constructs, and antibodies produced by the peptide immunogen constructs.

Abstract: The present invention relates to the treatment of herpes simplex virus (HSV) infection using an anti-HSV antibody. In particular, the anti-HSV antibody specifically binds to the glycoprotein D (gD) of herpes simplex virus-1 (HSV-1) and herpes simplex virus-2 (HSV-2). The treatment of the present invention is effective against drug-resistant and/or recurrent HSV infection.

Abstract: The present disclosure is directed to individual peptide immunogen constructs targeting portions of the Tau protein for the treatment and/or prevention of tauopathies. The present disclosure is also directed to compositions containing the peptide immunogen constructs, methods of making and using the peptide immunogen constructs, and antibodies produced by the peptide immunogen constructs.

Abstract: The present disclosure is directed to IgE EMPD peptide immunogen constructs and formulations thereof for the treatment of IgE-mediated allergic diseases. The IgE EMPD peptide immunogen constructs have a B cell epitope peptide of more than 20 amino acids, preferably cyclic, linked through an optional spacer to heterologous T helper cell (Th) epitopes derived from pathogen proteins. These peptide immunogen constructs and formulations thereof can stimulate the generation of highly specific antibodies in vaccinated hosts that are directed against the IgE EMPD peptide and are crossreactive with membrane-bound IgE on B lymphocytes committed to IgE secretion. The antibodies induced by the peptide immunogen constructs and formulations thereof in vaccinated hosts can induce apoptosis of IgE-expressing B cells and mediate Antibody Dependent Cellular Cytototoxity (ADCC), resulting in reduction of antigen-specific IgE and total IgE levels in vaccinated hosts to effectively treat IgE-mediated allergic pathology.

Abstract: The present invention is directed to novel promiscuous and artificial T helper cell epitopes (Th epitopes) designed to provide optimum immunogenicity of a target antigenic site. The target antigenic site can include a B cell epitope, a CTL epitope, a peptide hapten, a non-peptide hapten, or any immunologically reactive analogue thereof. The disclosed Th epitopes, when covalently linked to a target antigenic site in a peptide immunogen construct, elicit a strong B cell antibody response or an effector T cell response to the target antigenic site. The Th epitopes are immunosilent on their own, i.e., little, if any, of the antibodies generated by the peptide immunogen constructs will be directed towards the Th epitope, thus allowing a very focused immune response directed to the targeted antigenic site. The promiscuous artificial Th epitopes provide effective and safe peptide immunogens that do not generate inflammatory, anti-self, cell-mediated immune responses following administration.

Abstract: The present disclosure is directed to peptide immunogen constructs targeting portions of Pituitary adenylate cyclase-activating polypeptide (PACAP), compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions thereof. The disclosed peptide immunogen constructs have more than about 20 amino acids and contain (a) a B cell epitope having about more than about 9 contiguous amino acid residues from the PACAP receptor binding or activation regions of the full-length PACAP protein; (b) a heterologous Th epitope; and (c) an optional heterologous spacer. The disclosed PACAP peptide immunogen constructs stimulate the generation of highly specific antibodies directed PACAP for the prevention and/or treatment of migraine.