Patents by Inventor CHANGYOU MA
CHANGYOU MA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230321108Abstract: A unit dosage composition of an AKT inhibitor, and in particular, relates to a pharmaceutical composition in unit dosage form includes a compound of formula I-0 or a pharmaceutically acceptable salt thereof, wherein the mass of the compound I-0 or the pharmaceutically acceptable salt thereof is 5 mg to 400 mg calculated as free base.Type: ApplicationFiled: July 22, 2021Publication date: October 12, 2023Applicant: NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD.Inventors: Lei MIAO, Ying TANG, He TIAN, Changyou MA, Jian WU, Dan XU, Chunxia ZHU, Zhoushan TIAN
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Publication number: 20230286979Abstract: A salt of a dihydropyrido[2,3-d]pyrimidinone derivative, a preparation method thereof and the use thereof are provided. The salt is selected from fumarate, methanesulfonate, isethionate, ?-naphthalenesulfonate, p-toluenesulfonate, 1,2-ethanedisulfonate, oxalate, maleate, citrate, succinate, L-(+)-tartrate, hippurate, L-ascorbate, L-malate, benzoate, gentisate, a hydrochloride, a sulfate or a phosphate. The salt of the dihydropyrido[2,3-d]pyrimidinone derivative of the present application can be used in the treatment of breast cancer, prostate cancer, or ovarian cancer.Type: ApplicationFiled: July 22, 2021Publication date: September 14, 2023Applicant: NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD.Inventors: Changyou MA, He TIAN, Jianliang ZHAO, Donghui CHEN, Jian WU, Dan XU, Chunxia ZHU, Zhoushan TIAN
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Publication number: 20230271958Abstract: A salt and crystal form of a dihydropyrido[2,3-d]pyrimidine derivate, and specifically, a crystal form of a fumarate hydrate of compound 1, and a preparation method thereof are provided. In the formula, X is 2.0-3.0. The X-ray powder diffraction pattern expressed in 2? angles using Cu-Ka radiation has characteristic peaks at 2? values of 9.28°±0.2° and 3.63°±0.2°. The crystal form has good stability and can better be applied to clinical practice.Type: ApplicationFiled: July 22, 2021Publication date: August 31, 2023Applicant: NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD.Inventors: Jian WU, Changyou MA, He TIAN, Jianliang ZHAO, Donghui CHEN, Dan XU, Chunxia ZHU, Zhoushan TIAN
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Publication number: 20230227484Abstract: A pyrimidine compound as an AXL inhibitor is provided. The structure of the pyrimidine compound is as shown in general formula I, and the definition of each substituent is as described in the description. The present invention further provides a preparation method for the pyrimidine compound. The pyrimidine compound of the present invention has significant AXL inhibitory activity, and can be used as an AXL inhibitor.Type: ApplicationFiled: May 28, 2021Publication date: July 20, 2023Applicant: NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD.Inventors: Changyou MA, Linlin ZHANG, Dongdong LI, Youzhi WU, Haiwei FENG, Qiuhua ZHOU, Junjie PEI, Jian WU, Dan XU, Chunxia ZHU, Zhoushan TIAN
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Publication number: 20220144821Abstract: The present invention discloses an AKT inhibitor, and specifically relates to a compound represented by formula I or a pharmaceutically acceptable salt thereof. The present invention further provides a preparation method thereof, and the use thereof in prevention and/or treatment of a disease mediated by AKT protein kinase.Type: ApplicationFiled: January 22, 2020Publication date: May 12, 2022Inventors: Changyou Ma, He Tian, Jie An, Jianliang Zhao, Donghui Chen, Jian Wu, Dan Xu, Chunxia Zhu, Zhoushan Tian
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Patent number: 11325994Abstract: Disclosed is a catalyst component for olefin polymerization. The catalyst component comprises magnesium, titanium, halogen and an internal electron donor. The internal electron donor includes an imine compound with a ketone group as shown in Formula I. Disclosed further is a method of preparing the catalyst component, and a catalyst for olefin polymerization containing the catalyst component. When the catalyst is used in olefin polymerization reaction especially propene polymerization reaction, the catalyst has a high activity and a long term activity and good hydrogen response, and the obtained polymer has characteristics of an adjustable isotactic index and a relatively wide molecular weight distribution.Type: GrantFiled: September 22, 2017Date of Patent: May 10, 2022Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATIONInventors: Jun Wang, Mingzhi Gao, Haitao Liu, Jing Ma, Jixing Ma, Xiaoxia Cai, Jianhua Chen, Jianjun Hu, Changxiu Li, Zhihui Zhang, Ruilin Duan, Changyou Ma
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Patent number: 11129832Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.Type: GrantFiled: October 28, 2019Date of Patent: September 28, 2021Assignee: Genentech, Inc.Inventors: Anthony Estrada, Liting Dong, Kevin X. Chen, Paul Gibbons, Malcolm Huestis, Terry Kellar, Wen Liu, Changyou Ma, Joseph P. Lyssikatos, Alan G. Olivero, Snahel Patel, Daniel Shore, Michael Siu
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Publication number: 20200188397Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.Type: ApplicationFiled: October 28, 2019Publication date: June 18, 2020Applicant: Genentech, Inc.Inventors: Anthony Estrada, Liting Dong, Kevin X. Chen, Paul Gibbons, Malcolm Huestis, Terry Kellar, Wen Liu, Changyou Ma, Joseph Lyssikatos, Alan Olivero, Snahel Patel, Daniel Shore, Michael Siu
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Patent number: 10662268Abstract: Disclosed is a catalyst component for olefin polymerization. The catalyst component comprises magnesium, titanium, halogen and an internal electron donor. The internal electron donor includes an imine compound with a ketone group as shown in Formula I. Disclosed further is a method of preparing the catalyst component, and a catalyst for olefin polymerization containing the catalyst component. When the catalyst is used in olefin polymerization reaction especially propene polymerization reaction, the catalyst has a high long-term activity and good hydrogen response, and the obtained polymer has characteristics of an adjustable isotactic index and a relatively wide molecular weight distribution.Type: GrantFiled: September 22, 2017Date of Patent: May 26, 2020Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATIONInventors: Jun Wang, Mingzhi Gao, Jing Ma, Haitao Liu, Jianhua Chen, Xiaoxia Cai, Jixing Ma, Jianjun Hu, Changxiu Li, Zhihui Zhang, Changyou Ma
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Publication number: 20190256623Abstract: Disclosed is a catalyst component for olefin polymerization. The catalyst component comprises magnesium, titanium, halogen and an internal electron donor. The internal electron donor includes an imine compound with a ketone group as shown in Formula I. Disclosed further is a method of preparing the catalyst component, and a catalyst for olefin polymerization containing the catalyst component. When the catalyst is used in olefin polymerization reaction especially propene polymerization reaction, the catalyst has a high long-term activity and good hydrogen response, and the obtained polymer has characteristics of an adjustable isotactic index and a relatively wide molecular weight distribution.Type: ApplicationFiled: September 22, 2017Publication date: August 22, 2019Inventors: Jun WANG, Mingzhi GAO, Jing MA, Haitao LIU, Jianhua CHEN, Xiaoxia CAI, Jixing MA, Jianjun HU, Changxiu LI, Zhihui ZHANG, Changyou MA
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Publication number: 20190211119Abstract: Disclosed is a catalyst component for olefin polymerization. The catalyst component comprises magnesium, titanium, halogen and an internal electron donor. The internal electron donor includes an imine compound with a ketone group as shown in Formula I. Disclosed further is a method of preparing the catalyst component, and a catalyst for olefin polymerization containing the catalyst component. When the catalyst is used in olefin polymerization reaction especially propene polymerization reaction, the catalyst has a high activity and a long term activity and good hydrogen response, and the obtained polymer has characteristics of an adjustable isotactic index and a relatively wide molecular weight distribution.Type: ApplicationFiled: September 22, 2017Publication date: July 11, 2019Inventors: Jun WANG, Mingzhi GAO, Haitao LIU, Jing MA, Jixing MA, Xiaoxia CAI, Jianhua CHEN, Jianjun HU, Changxiu LI, Zhihui ZHANG, Ruilin DUAN, Changyou MA
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Patent number: 10208145Abstract: The present invention provides a catalyst component for olefin polymerization, obtained by a reaction of magnesium, titanium, halogen and an internal electron donor, the internal electron donor comprising an imine compound as shown in Formula Z. The present invention also provides a preparation method of the catalyst component, and a catalyst for olefin polymerization containing the same. When the catalyst of the present invention is used for olefin polymerization reaction, the catalyst has a high activity, and a slow rate of activity decay, and the obtained polymer has a high isotacticity index, and a wide molecular weight distribution.Type: GrantFiled: April 24, 2015Date of Patent: February 19, 2019Assignees: China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry, China Petroteum & Chemical CorporationInventors: Mingzhi Gao, Jun Wang, Haitao Liu, Jing Ma, Jianhua Chen, Jixing Ma, Xiaoxia Cai, Changxiu Li, Jianjun Hu, Xiaofan Zhang, Xianzhong Li, Zhihui Zhang, Ruilin Duan, Linna Yang, Changyou Ma
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Patent number: 10184017Abstract: The present invention discloses a catalyst component for propene polymerization, comprising titanium, magnesium, halogen, and internal electron donor A, wherein said internal electron donor A is selected from the compounds as shown in Formula I, in Formula I, R is selected from hydrogen, hydroxyl, and substituted or unsubstituted C1-C30 hydrocarbyl, preferably from hydrogen, hydroxyl, and substituted or unsubstituted C1-C20 alkyl, C6-C30 aryl, C6-C30 heteroaryl, C7-C30 alkylaryl and C7-C30 arylalkyl; R1 and R2 may be identical to or different from each other, and are selected from hydrogen and substituted or unsubstituted C1-C30 hydrocarbyl, preferably from hydrogen and substituted or unsubstituted C1-C20 alkyl, C6-C30 aryl, C7-C30 alkylaryl and C7-C30 arylalkyl. According to the present invention, by using the compound as shown in Formula I as internal electron donor compound for propene polymerization, the catalyst has a higher activity, and a slow rate of delay of activity.Type: GrantFiled: April 24, 2015Date of Patent: January 22, 2019Assignees: China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry, China Petroleum & Chemical CorporationInventors: Jun Wang, Mingzhi Gao, Haitao Liu, Jing Ma, Jianhua Chen, Xiaoxia Cai, Jixing Ma, Changxiu Li, Jianjun Hu, Xiaofan Zhang, Xianzhong Li, Zhihui Zhang, Ruilin Duan, Linna Yang, Changyou Ma
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Patent number: 10010549Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.Type: GrantFiled: October 29, 2015Date of Patent: July 3, 2018Assignee: Genentech, Inc.Inventors: Anthony Estrada, Liting Dong, Kevin X. Chen, Paul Gibbons, Malcolm Huestis, Terry Kellar, Wen Liu, Changyou Ma, Joseph Lyssikatos, Alan Olivero, Snahel Patel, Daniel Shore, Michael Siu
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Publication number: 20180133219Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.Type: ApplicationFiled: January 11, 2018Publication date: May 17, 2018Applicant: Genentech, Inc.Inventors: Anthony Estrada, Liting Dong, Kevin X. Chen, Paul Gibbons, Malcolm Huestis, Terry Kellar, Wen Liu, Changyou Ma, Joseph Lyssikatos, Alan Olivero, Snahel Patel, Daniel Shore, Michael Siu
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Patent number: 9951157Abstract: Spherical carriers for an olefin polymerization catalyst, catalyst components, catalysts, and preparation methods therefor are disclosed. The method for preparing the spherical carriers comprises the following steps: (1) reacting, in the presence of at least one polymeric dispersion stabilizer, a magnesium halide with an organic compound containing active hydrogen to form a complex solution; (2) reacting said complex solution with an alkylene oxide-type compound to directly precipitate solid particles; and (3) recovering the solid particles to obtain spherical carriers. When a catalyst prepared by using the present spherical carrier is used in propylene polymerization, said catalyst exhibits high polymerization activity and high stereo-directing ability.Type: GrantFiled: October 17, 2014Date of Patent: April 24, 2018Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATIONInventors: Weili Li, Xianzhi Xia, Yuexiang Liu, Yongtai Ling, Jin Zhao, Jigui Zhang, Futang Gao, Ping Gao, Yang Tan, Renqi Peng, Zhihui Zhang, Jie Lin, Ruilin Duan, Changyou Ma
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Publication number: 20170073441Abstract: The present invention provides a catalyst component for olefin polymerization, obtained by a reaction of magnesium, titanium, halogen and an internal electron donor, the internal electron donor comprising an imine compound as shown in Formula Z. The present invention also provides a preparation method of the catalyst component, and a catalyst for olefin polymerization containing the same. When the catalyst of the present invention is used for olefin polymerization reaction, the catalyst has a high activity, and a slow rate of activity decay, and the obtained polymer has a high isotacticity index, and a wide molecular weight distribution.Type: ApplicationFiled: April 24, 2015Publication date: March 16, 2017Applicants: China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry, China Petroteum & Chemical CorporationInventors: Mingzhi GAO, Jun WANG, Haitao LIU, Jing MA, Jianhua CHEN, Jixing MA, Xiaoxia CAI, Changxiu LI, Jianjun HU, Xiaofan ZHANG, Xianzhong LI, Zhihui ZHANG, Ruilin DUAN, Linna YANG, Changyou MA
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Publication number: 20170044280Abstract: The present invention discloses a catalyst component for propene polymerization, comprising titanium, magnesium, halogen, and internal electron donor A, wherein said internal electron donor A is selected from the compounds as shown in Formula I, in Formula I, R is selected from hydrogen, hydroxyl, and substituted or unsubstituted C1-C30 hydrocarbyl, preferably from hydrogen, hydroxyl, and substituted or unsubstituted C1-C20 alkyl, C6-C30 aryl, C6-C30 heteroaryl, C7-C30 alkylaryl and C7-C30 arylalkyl; R1 and R2 may be identical to or different from each other, and are selected from hydrogen and substituted or unsubstituted C1-C30 hydrocarbyl, preferably from hydrogen and substituted or unsubstituted C1-C20 alkyl, C6-C30 aryl, C7-C30 alkylaryl and C7-C30 arylalkyl. According to the present invention, by using the compound as shown in Formula I as internal electron donor compound for propene polymerization, the catalyst has a higher activity, and a slow rate of delay of activity.Type: ApplicationFiled: April 24, 2015Publication date: February 16, 2017Applicants: China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry China Petroleum & Chemical CorporationInventors: Jun WANG, Mingzhi GAO, Haitao LIU, Jing MA, Jianhua CHEN, Xiaoxia CAI, Jixing MA, Changxiu LI, Jianjun HU, Xiaofan ZHANG, Xianzhong LI, Zhihui ZHANG, Ruilin DUAN, Linna YANG, Changyou MA
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Publication number: 20160251457Abstract: Spherical carriers for an olefin polymerization catalyst, catalyst components, catalysts, and preparation methods therefor are disclosed. The method for preparing the spherical carriers comprises the following steps: (1) reacting, in the presence of at least one polymeric dispersion stabilizer, a magnesium halide with an organic compound containing active hydrogen to form a complex solution; (2) reacting said complex solution with an alkylene oxide-type compound to directly precipitate solid particles; and (3) recovering the solid particles to obtain spherical carriers. When a catalyst prepared by using the present spherical carrier is used in propylene polymerization, said catalyst exhibits high polymerization activity and high stereo-directing ability.Type: ApplicationFiled: October 17, 2014Publication date: September 1, 2016Inventors: Weili Li, Xianzhi Xia, Yuexiang Liu, Yongtai Ling, Jin Zhao, Jigui Zhang, Futang Gao, Ping Gao, Yang Tan, Renqi Peng, Zhihui Zhang, Jie Lin, Ruilin Duan, Changyou Ma
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Publication number: 20160052940Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.Type: ApplicationFiled: October 29, 2015Publication date: February 25, 2016Applicant: GENENTECH, INC.Inventors: ANTHONY ESTRADA, LITING DONG, KEVIN X. CHEN, PAUL GIBBONS, MALCOLM HUESTIS, TERRY KELLAR, WEN LIU, CHANGYOU MA, JOSEPH LYSSIKATOS, ALAN OLIVERO, SNAHEL PATEL, DANIEL SHORE, MICHAEL SIU