Abstract: The present disclosure provides a proteolysis-targeting compound TPB-L-E3B, a method for synthesizing the same, and use thereof. The compound can treat human tumor diseases through the eRF3a-targeting proteolysis mechanism, and exhibits great potential in treating such diseases in in-vitro studies, particularly, in treating diseases such as prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer, and the like.

Abstract: A thermal fuse resistor including a ceramic substrate, a resistor body, a temperature sensing body, a first electrode cap, a second electrode cap, a first lead wire, a second lead wire, and a third lead wire. A first end of the ceramic substrate is provided with a first electrode cap, and a second end of the ceramic substrate is provided with a second electrode cap. The first electrode cap includes a main body, an inner end, and an outer end with an opening. The outer end includes an everted edge closely contacting the first end of the ceramic substrate. The main body and the inner end are arranged inside the ceramic substrate. The first lead wire extends outward from an outer end. One end of the third lead wire is electrically connected to the second electrode cap.