Patents by Inventor Channing Der

Channing Der has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MYC AMPLIFICATION DRIVES RESISTANCE TO PAN-RAS INHIBITORS IN PANCREATIC CANCER
    Publication number: 20250250640
    Abstract: Methods of treating a tumor in a subject comprising administering to the subject an amount of a RASMULTI inhibitor and an amount of a TEAD inhibitor, effective to treat a tumor, and methods of treating a tumor resistant to a RASMULTI inhibitor therapy comprising administering to a tumor so-identified an amount of a RASMULTI inhibitor and an amount of a TEAD inhibitor, effective to treat a tumor resistant to a RASMULTI inhibitor therapy.
    Type: Application
    Filed: January 23, 2025
    Publication date: August 7, 2025
    Inventors: Kenneth Paul OLIVE, Urszula WASKO, Channing DER
  • Methods and compositions using RNA interference for inhibition of KRAS
    Patent number: 10619159
    Abstract: The invention relates to the inhibition of expression of mutant KRAS sequences using RNA interference.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 14, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Chad Pecot, Adrienne Cox, Channing Der
  • METHODS AND COMPOSITIONS USING RNA INTERFERENCE FOR INHIBITION OF KRAS
    Publication number: 20190055562
    Abstract: The invention relates to the inhibition of expression of mutant KRAS sequences using RNA interference.
    Type: Application
    Filed: January 19, 2017
    Publication date: February 21, 2019
    Inventors: Chad Pecot, Adrienne Cox, Channing Der
  • Shc proteins
    Patent number: 6077686
    Abstract: A Shc protein which is characterized as follows: (a) containing a C-terminal Src homology 2 (SH2) domain, a central proline-rich region (CH1), and an N-terminal phosphotyrosine binding (PTB) domain; (b) it is predominantly expressed in the adult brain; (c) it binds through its SH2 domain to proteins containing the consensus sequence pTyr-(hydrophobic/Glu)-(hydrophobic/Met/Tyr/Ile)-(Ile/Leu/Met/Phe/Tyr); and (d) it associates through its PTB domain with proteins containing the consensus sequence Asn-Pro-X-pTyr where X is any amino acid; nucleic acids encoding the protein; and uses of the protein. The Shc proteins mediate signaling from tyrosine kinases in the nervous system.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: June 20, 2000
    Assignees: Mount Sinai Hospital Corporation, University of North Carolina at Chapel Hill
    Inventors: Channing Der, John O'Bryan, Anthony Pawson