Abstract: In some embodiments, the present invention provides a method of purifying a protein of interest with a reduced level of aggregation formation in cation exchange (CEX) chromatography, comprising: (a) providing a mixture comprising the protein of interest and one or more contaminants; (b) loading the mixture onto a CEX resin coupled with arginine; and (c) eluting the protein of interest from the resin, thereby purifying the protein of interest with a reduced level of aggregation formation in CEX chromatography.

Abstract: An aqueous hybrid super capacitor is comprised of a super capacitor positive electrode, a gas generating electrode which has oxygen generating activity, and a zinc negative electrode, separated in an aqueous electrolyte with pH value above 2.5; use the super capacitor positive electrode and the zinc negative electrode to perform cycle of charging and discharging; use the gas generating electrode and the zinc negative electrode to recover capacity of the zinc negative electrode and recondition the zinc negative electrode; relating to the electrochemical energy storage area, it has characteristics of extremely long cycle life, low cost, high power density, enduring deep charging and discharging, easily assembled and connected, being suitable for large scale energy storage and high power energy storage.

Abstract: The present invention relates to infrared imaging, providing a multi-purpose infrared imaging device. The multi-purpose infrared imaging device comprises a housing. An optical lens module is mounted at a front end of the housing. The housing has an opening. A power module for blocking the opening is detachably mounted in the housing. An infrared sensor module, an infrared signal processing module and an infrared digital image processing module are further mounted in the housing, and both of the infrared sensor module and the infrared digital image processing module are electrically connected to the infrared signal processing module and all of the three modules are electrically connected to the power module. The power module, the infrared sensor module, the infrared signal processing module and the infrared digital image processing module are integrated in the housing in the imaging device, such that the imaging device has multiple functions to effectively meet the multifunctional needs of users.

Abstract: The present invention relates to a process for preparing substituted biphenyls via Suzuki coupling using specific phosphorus ligands and a solvent mixture containing water, a non-polar organic solvent and a polar aprotic co-solvent.

Abstract: A receiving device comprises a first receiving circuit, for receiving a plurality of signals and comparing a plurality of signal powers of the plurality of signals with a first threshold, to generate a first plurality of comparison results; a second receiving circuit, for receiving the plurality of signals and comparing the plurality of signal powers of the plurality of signals with a second threshold, to generate a second plurality of comparison results, wherein the first threshold is smaller than the second threshold; and a control circuit, coupled to the first receiving circuit and the second receiving circuit, for determining whether an average signal power of the plurality of signals is greater than a reference power according to the first plurality of comparison results and the second plurality of comparison results, to generate a determination result.

Abstract: A dual-mode signal amplifying circuit includes: a first and a second input terminals for receiving differential input signals; two output terminals for providing differential output signals; a first through a third current sources; a first switch positioned between the first current source and a first node, and controlled by the first input terminal; a second switch positioned between the first current source and a second node, and controlled by the second input terminal; a third switch positioned between the first node and a fixed-voltage terminal, and controlled by a third node; a fourth switch positioned between the second node and a fixed-voltage terminal, and controlled by the third node; a fifth switch positioned between the second current source and a fixed-voltage terminal, and controlled by the first node; and a sixth switch positioned between the third current source and a fixed-voltage terminal, and controlled by the second node.

Abstract: Example implementations described herein are directed to a method and apparatus for improving insertion loss of connector stub and thereby increasing a system's signal bandwidth. This technique shapes the connector stub in a specific way to shift its resonant frequency higher while having equal or better electrical performance below the original resonant frequency.

Abstract: The present invention relates to a synthesis process of suvorexant, novel compounds represented by formulas II, III, IV or V, or salts thereof for preparing suvorexant, and a method for preparing the intermediates. The preparation method uses a chiral starting material to synthesize chiral compounds represented by formulas II, III, IV or V, the compounds obtained being used for synthesizing the suvorexant. The preparation method has the advantages of simple operation, low cost, mild reaction conditions, simple post-treatment, easy to purify, high yield, high ee value for the product, and easy to industrialize. In the reaction route shown, R represents benzyl, allyl or 1-phenethyl, or optionally substituted benzyl at the 2 position to 6 position, such as 4-methoxybenzyl, 4-nitrobenzyl, 2-methylbenzyl, 4-chlorobenzyl or 3-fluorobenzyl.

Abstract: A computer-implemented method for downloading and displaying pictures associated with instant messages is performed at a computing device. The computing device displays a list of instant messages on the screen, at least one of the instant messages having an associated picture and including address information of the picture. While the picture is being downloaded, the computing device detects a user instruction to slide the list of instant messages on the screen. In response to the user instruction, the computing device pauses the download of the picture and determines, among the list of instant messages, a second instant message having an associated second picture and including address information of the second picture based on the user instruction. The computing device then downloads the second picture associated with the second instant message according to the address information without receiving a download instruction from the user of the computing device.

Abstract: Provided is a teeth cleaning device that includes a gel cartridge, a plurality of light emitting diodes, a mouth guard, and a controller. The cartridge stores a gel. The light emitting diodes emit a cold light. The mouth guard has a generally arcuate shape and includes a first recess, a second recess opposite the first recess, a cavity, a first surface, and a plurality of first openings. The first recess is located on a top side of the guard to receive a first row of teeth, and the second recess is located on the bottom side of the guard to receive a second row of teeth. The cavity is between the first recess and the second recess. The first surface is in communication with the cold light of the light emitting diodes. The assembly has a generally arcuate shape and is disposed in the cavity of the guard between the first recess and the second recess.

Abstract: A system and method for fluorescence imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A fluorescent imaging system is provided that has a dye carrier coupled to the distal end of a probe containing a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest. The resulting fluorescence images permit the acquisition of diagnostic information on the progression of diseases at cellular/tissue level in patients.

Abstract: An apparatus may include a processor to retrieve a stereo three dimensional (S3D) frame of an S3D game, the frame comprising a red-green-blue (RGB) frame and depth frame; and an interest aware disparity mapping component to: generate a depth edge frame from the depth frame; and to generate a depth distribution diagram for the depth frame based on the depth edge frame, the depth distribution diagram defining a multiplicity of camera regions for generating a mapped S3D frame for a target device based upon viewing parameters of the target device.

Abstract: A dual-entry keyring includes a ring body in a two-turn ring shape design, defining a first end and a second end respectively disposed at opposing top and bottom sides thereof beyond superimposition and a first press portion and a second press portion arranged between the first end and the second end to face toward each other and respectively outwardly curved so that a gap is defined between the first press portion and the second press portion. Further, the part of the first turn of the two-turn ring shape design of the ring body beyond the first press portion is closely abutted to the part of the second turn of the two-turn ring shape design of the ring body beyond the second press portion so that a stress point is formed at each of two opposite lateral sides of the gap between the first press portion and the second press portion.

Abstract: Example implementations described herein are directed to a method and apparatus for improving insertion loss of connector stub and thereby increasing a system's signal bandwidth. This technique shapes the connector stub in a specific way to shift its resonant frequency higher while having equal or better electrical performance below the original resonant frequency.

Abstract: An assembly of semiconductor and highly thermally conductive heat-dissipating substrates includes a thermally conductive metal substrate, a supporting substrate, and a vertical heat-dissipating block. The thermally conductive metal substrate comprises a substrate body, a receiving groove in the substrate body, and a thin-layer portion at a bottom side of the receiving groove. The supporting substrate is provided in the receiving groove. The two vertically opposite sides of the supporting substrate respectively form a carrying surface for carrying a laser diode LD and a heat-dissipating surface in contact with the thin-layer portion at the bottom side of the receiving groove. The vertical heat-dissipating block is provided on a side of the thermally conductive metal substrate opposing to a side with the receiving groove.

Abstract: A sensor array for simultaneously measuring electrophysiological responses and contractility responses of a tissue includes: a substrate; a multi-electrode array (MEA) disposed in or on the substrate; and a plurality of interdigitized electrodes (IDEs) disposed in or on the substrate. The MEA and the IDEs are interpenetrating within a plane substantially parallel to an upper surface of the substrate. Systems for measuring such responses using the sensor array may also include contacts and/or connectors for interfacing with external control devices, electrodes, and cell culture components such as a chamber and lid. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.

Abstract: The present disclosure involves method and apparatus for de-embedding test fixture to extract the electrical behavior of device under test. A calibration board with both “1× open” and “1× short” test structures is fabricated and measured by equipment such as vector network analyzer that produces S parameters. The S parameters of “1× open” and “1× short”, with or without correction factors, are combined to produce the S parameters of equivalent “2× thru” test structure. The S parameters of equivalent “2× thru” are used subsequently to de-embed the test fixture. This present disclosure gives a simpler and more accurate method to create the S parameters of “2× thru” for de-embedding.