Patents by Inventor Chao-Hung Kao
Chao-Hung Kao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124844Abstract: The present disclosure provides a method for preparing a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors, the composition prepared by the method, and use of the composition for treating arthritis. The composition of the present disclosure achieves the effect of treating arthritis through various efficacy experiments.Type: ApplicationFiled: October 4, 2023Publication date: April 18, 2024Inventors: Chia-Hsin Lee, Po-Cheng Lin, Yong-Cheng Kao, Ming-Hsi Chuang, Chun-Hung Chen, Chao-Liang Chang, Kai-Ling Zhang
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Publication number: 20240126327Abstract: The present disclosure provides an electronic wearable device. The electronic wearable device includes a first module having a first contact and a second module having a second contact. The first contact is configured to keep electrical connection with the second contact in moving with respect to each other during a wearing period.Type: ApplicationFiled: October 14, 2022Publication date: April 18, 2024Applicant: Advanced Semiconductor Engineering, Inc.Inventors: Chao Wei LIU, Wei-Hao CHANG, Yung-I YEH, Jen-Chieh KAO, Tun-Ching PI, Ming-Hung CHEN, Hui-Ping JIAN, Shang-Lin WU
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Patent number: 9309501Abstract: Isolated DNA polymerase and the mutant DNA polymerases thereof are provided. The DNA polymerases have good thermostability.Type: GrantFiled: December 23, 2013Date of Patent: April 12, 2016Assignee: Industrial Technology Research InstituteInventors: Tseng-Huang Liu, Pei-Shin Jiang, Chih-Lung Lin, Su-Jan Lee, Chao-Hung Kao
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Publication number: 20140186894Abstract: Isolated DNA polymerase and the mutant DNA polymerases thereof are provided. The DNA polymerases have good thermostability.Type: ApplicationFiled: December 23, 2013Publication date: July 3, 2014Applicant: Industrial Technology Research InstituteInventors: Tseng-Huang Liu, Pei-Shin Jiang, Chih-Lung Lin, Su-Jan Lee, Chao-Hung Kao
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Publication number: 20130309732Abstract: A biosynthesis method of norephedrine with specific optical activities is revealed to convert and generate optical isomers with specific optical activities by biocatalysis. A two-step biotransformation reaction is carried by a whole-cell biocatalyst for converting reaction substrates, benzaldehyde and pyruvate, to L-phenylacetylcarbinol (L-PAC) in the first step and the yield of the L-PAC is 99%, and then an amino donor (L-alanine) is added and the transamination of the L-PAC is catalyzed by a transaminase with optical specificity for biosynthesizing the norephedrine with high optical purity. The pyruvate is produced from the amino donor, L-alanine, by the transamination in the reaction system, so that the pyruvate is regenerated in the reaction system without being added again.Type: ApplicationFiled: May 18, 2012Publication date: November 21, 2013Applicant: HUNGKUANG UNIVERSITYInventors: CHAO-HUNG KAO, JIAN-SIN LIN
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Patent number: 8586095Abstract: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.Type: GrantFiled: August 29, 2006Date of Patent: November 19, 2013Assignee: Industrial Technology Research InstituteInventors: Wen Hsiang Chang, Chao-Hung Kao, Chin-I Lin, Shian-Jy Wang
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Patent number: 8447069Abstract: An apparatus and method for moving object detection computes a corresponding frame difference for every two successive image frames of a moving object, and segments a current image frame of the two successive image frames into a plurality of homogeneous regions. At least a candidate region is further detected from the plurality of homogeneous regions. The system gradually merges the computed frame differences via a morphing-based technology and fuses the merged frame difference with the at least a candidate region, thereby obtaining the location and a complete outline of the moving object.Type: GrantFiled: February 9, 2010Date of Patent: May 21, 2013Assignee: Industrial Technology Research InstituteInventors: Chung-Hsien Huang, Cheng-Chuan Chou, Yi-Ta Wu, Chao-Hung Kao, Ming-Yu Shih
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Publication number: 20110142283Abstract: An apparatus and method for moving object detection computes a corresponding frame difference for every two successive image frames of a moving object, and segments a current image frame of the two successive image frames into a plurality of homogeneous regions. At least a candidate region is further detected from the plurality of homogeneous regions. The system gradually merges the computed frame differences via a morphing-based technology and interests with the at least a candidate region, thereby obtains the location and a complete outline of the moving object.Type: ApplicationFiled: February 9, 2010Publication date: June 16, 2011Inventors: Chung-Hsien Huang, Cheng-Chuan Chou, Yi-Ta Wu, Chao-Hung Kao, Ming-Yu Shih
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Patent number: 7829026Abstract: A magnetic separation device, comprising: at least a test tube base, for receiving at least a test tube; and a magnetic member, pivotally connected to the at least one test tube base and capable of generating a magnetic force. With the aforesaid device, the test tube being received in the test tube base can be moved toward/away from the magnetic member while the magnetic member and the test tube base are driven to rotate about a pivotal end connecting the two, and thereby, the strength of the magnetic force applied on a mixture containing in the test tube by the magnetic member is varied accordingly.Type: GrantFiled: January 24, 2008Date of Patent: November 9, 2010Assignee: Industrial Technology Research InstituteInventors: Chih-Hsien Su, Chao-Hung Kao, Yuh-Jiuan Lin
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Publication number: 20100204508Abstract: A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10 alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.Type: ApplicationFiled: April 26, 2010Publication date: August 12, 2010Applicant: Industrial Technology Research InstituteInventors: Abraham JOSEPHK, Hui-Ju CHO, Yu-Hau SHIH, Chao-Hung KAO, Huang-Chien LIANG
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Patent number: 7763169Abstract: A magnetic separation device, comprising: a separator, including a top base and a bottom base; at least a groove set, each composed of two arc-like grooves having curvatures opposite to each other; at least a magnetic member, being movably fitted inside the two arc-like grooves of the at least one groove set; and at least a test tube slot, each being formed at the outer rim of a base selected from the group consisting of the top and the bottom base of the separator; wherein the top and the bottom bases are assembled by means of a pivotal axis piecing through about at the center of the top and the bottom bases for enabling the two bases to rotate relative to each other; and one of the two arc-like groove is formed on the top base at a surface thereof facing toward the bottom base while forming another arc-like groove on the bottom base at a surface thereof facing toward the top base.Type: GrantFiled: January 15, 2008Date of Patent: July 27, 2010Assignee: Industrial Technology Research InstituteInventors: Chih-Hsien Su, Chao-Hung Kao, Yuh-Jiuan Lin
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Patent number: 7732558Abstract: A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.Type: GrantFiled: December 27, 2005Date of Patent: June 8, 2010Assignee: Industrial Technology Research InstituteInventors: Abraham Josephk, Hui-Ju Cho, Yu-Hau Shih, Chao-Hung Kao, Huang-Chien Liang
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Publication number: 20090028759Abstract: A magnetic separation device, comprising: at least a test tube base, for receiving at least a test tube; and a magnetic member, pivotally connected to the at least one test tube base and capable of generating a magnetic force. With the aforesaid device, the test tube being received in the test tube base can be moved toward/away from the magnetic member while the magnetic member and the test tube base are driven to rotate about a pivotal end connecting the two, and thereby, the strength of the magnetic force applied on a mixture containing in the test tube by the magnetic member is varied accordingly.Type: ApplicationFiled: January 24, 2008Publication date: January 29, 2009Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: CHIH-HSIEN SU, CHAO-HUNG KAO, YUH-JIUAN LIN
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Publication number: 20090028758Abstract: A magnetic separation device, comprising: a separator, including a top base and a bottom base; at least a groove set, each composed of two arc-like grooves having curvatures opposite to each other; at least a magnetic member, being movably fitted inside the two arc-like grooves of the at least one groove set; and at least a test tube slot, each being formed at the outer rim of a base selected from the group consisting of the top and the bottom base of the separator; wherein the top and the bottom bases are assembled by means of a pivotal axis piecing through about at the center of the top and the bottom bases for enabling the two bases to rotate relative to each other; and one of the two arc-like groove is formed on the top base at a surface thereof facing toward the bottom base while forming another arc-like groove on the bottom base at a surface thereof facing toward the top base.Type: ApplicationFiled: January 15, 2008Publication date: January 29, 2009Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: CHIH-HSIEN SU, CHAO-HUNG KAO, YUH-JIUAN LIN
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Publication number: 20070154397Abstract: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.Type: ApplicationFiled: August 29, 2006Publication date: July 5, 2007Inventors: Wen Hsiang Chang, Chao-Hung Kao, Chin-I Lin, Shian-Jy Wang
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Publication number: 20060165601Abstract: A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.Type: ApplicationFiled: December 27, 2005Publication date: July 27, 2006Applicant: Industrial Technology Research InstituteInventors: Abraham Josephk, Hui-Ju Cho, Yu-Hau Shih, Chao-Hung Kao, Huang-Chien Liang
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Publication number: 20060140865Abstract: A nano-micelle carrier used in near infrared image detection. The carrier includes a nano-micelle comprising a plurality of block copolymers having critical micelle concentration (CMC) and a near infrared dye grafted onto the micelle surface, wherein the carrier has a hydrophobic interior and a hydrophilic surface. The invention also provides a method of detecting a near infrared image.Type: ApplicationFiled: December 27, 2005Publication date: June 29, 2006Inventors: Wen Chang, Chao-Hung Kao, Chi-Min Chau, Chin-I Lin, Shian-Jy Wang
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Patent number: 6403357Abstract: The invention discloses a novel thermostable D-hydantoinase, and relates to the nucleic acid sequence, amino acid sequence and vector constructs of the enzyme. The thermostable D-hydantoinase of the invention shows about 45%-70% identity in amino acid sequence with other D-hydantoinases. The thermostable D-hydantoinase of the invention converts 5′-substituted D-hydantoinase to the corresponding N-carbamoyl-D- and/or -L-&agr;/&bgr;-amino acids, and retains at least 50% activity after 30 days at 50° C. In addition, the enzyme activity can also enhanced by certain divalent cations.Type: GrantFiled: April 18, 2001Date of Patent: June 11, 2002Assignee: National Science CouncilInventors: Wen-Hwei Hsu, Chao-Hung Kao
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Publication number: 20020045238Abstract: The invention discloses a novel thermostable D-hydantoinase, and relates to the nucleic acid sequence, amino acid sequence and vector constructs of the enzyme. The thermostable D-hydantoinase of the invention shows about 45%-70% identity in amino acid sequence with other D-hydantoinases. The thermostable D-hydantoinase of the invention converts 5′-substituted D-hydantoinase to the corresponding N-carbamoyl-D- and/or -L-&agr;/&bgr;-amino acids, and retains at least 50% activity after 30 days at 50° C. In addition, the enzyme activity can also enhanced by certain divalent cations.Type: ApplicationFiled: April 18, 2001Publication date: April 18, 2002Inventors: Wen-Hwei Hsu, Chao-Hung Kao