Patents by Inventor Chao-Min Liu

Chao-Min Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of antibiotic X-14547
    Patent number: 4181573
    Abstract: The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. the antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: January 1, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John Westley, Chao-Min Liu
  • 3-Ethyl-1,3-dihydro-3-methoxy-2H-indole 2-one
    Patent number: 4170595
    Abstract: The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. The antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: October 9, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John Westley, Chao-Min Liu
  • Antibiotic X-14547 and its use for increasing feed efficiency in ruminants
    Patent number: 4167579
    Abstract: The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. The antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: September 11, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John Westley, Chao-Min Liu
  • Deoxy-(0-8)-epi-17-salinomycin (1)
    Patent number: 4137241
    Abstract: A compound which is the C-17 epimer of deoxy-(0-8)-epi-17-salinomycin is produced by the fermentation of a strain of Streptomyces albus 80,614 (ATCC 21,838). The compound exhibits activity as an antimicrobial and antihypertensive agent.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: January 30, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, John Westley
  • Antibiotic X-14547
    Patent number: 4100171
    Abstract: The invention relates to a new and useful antibiotic substance which is of the formula ##STR1## and to processes for its production and recovery. The antibiotic which exhibits ionophoric properties, is classified as a polyether group antibiotic. The antibiotic of formula I is effective in inhibiting the growth of gram positive bacteria and exhibits utility as an antihypertensive agent and as a compound to improve ruminant feed utilization. The antibiotic of Formula I is prepared by cultivating a strain of Streptomyces sp. X-14547 in an aqueous carbohydrate solution containing nitrogenous nutrients and mineral salts and thereafter isolating the antibiotic from the fermentation broth.
    Type: Grant
    Filed: August 6, 1976
    Date of Patent: July 11, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John Westley, Chao-Min Liu
  • Process to produce lysocellin
    Patent number: 4033823
    Abstract: A fermentation process is disclosed wherein the known antibiotic lysocellin is produced by the fermentation of a new species of Streptomyces denominated as Streptomyces longwoodensis (X-14537).
    Type: Grant
    Filed: August 12, 1976
    Date of Patent: July 5, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, Norberto Palleroni, Theron Hermann, Barbara Prosser