Abstract: A new mutant of D-amino acid transaminase, based on supercomputing-assisted technology, belongs to the fields of computational biology, computer-aided design, and enzyme engineering technology, and specifically relates to mutants of D-amino acid transaminase obtained based on supercomputing-assisted technology and applications thereof. Compared to the wild-type enzyme, the aforementioned mutant of D-amino acid transaminase exhibits a half-life (t1/2) of over 12 hours at 40° C., while it is only 8.8 minutes for the wild-type D-amino acid transaminase. The half-inactivation temperature (T5015) of the mutant is 45.3° C., approximately 5.4° C. higher than that of the wild-type D-amino acid transaminase. This substantially enhances its thermal stability, enzymatic activity, etc., effectively broadening its application fields and scope. The mutant has a wide range of industrial applications and thus holds substantial practical value.

Abstract: A coil-type fluid-impervious zipper including: a left chain connected with a left supporting fabric tape, and a right chain connected with a right supporting fabric tape; where a left filler structure made of a first thermoplastic elastomer is formed within the left chain, a right filler structure made of the first thermoplastic elastomer is formed within the right chain, a left attachment strip made of a second thermoplastic elastomer is connected to a right side of the left filler structure, a right attachment strip made of the second thermoplastic elastomer is connected to a left side of the right filler structure, and when the coil-type fluid-impervious zipper is zipped up, the left attachment strip and the right attachment strip are compressed to engage with each other within a first gap formed between the left filler structure and the right filler structure.

Abstract: A slider capable of minimizing scratching on zipper, which includes a top side plate, a bottom side plate opposing the top side plate, and a link part connecting the top side plate and the bottom side plate, the bottom side plate having two side walls extending from two side edges thereof, the top side plate having a top inner surface and a top outer surface, the bottom side plate having a bottom inner surface and a bottom outer surface, and an internal passage being formed by the top inner surface, the bottom inner surface, the side walls and the link part; and the slider being characterized in that a pair of parallel longitudinal grooves are formed in the top inner surface and/or the bottom inner surface during a molding process to accommodate at least a part of a set of border lines of a combination mold.

Abstract: A new mutant of D-amino acid transaminase, based on supercomputing-assisted technology, belongs to the fields of computational biology, computer-aided design, and enzyme engineering technology, and specifically relates to mutants of D-amino acid transaminase obtained based on supercomputing-assisted technology and applications thereof. Compared to the wild-type enzyme, the aforementioned mutant of D-amino acid transaminase exhibits a half-life (t1/2) of over 12 hours at 40° C., while it is only 8.8 minutes for the wild-type D-amino acid transaminase. The half-inactivation temperature (T505) of the mutant is 45.3° C., approximately 5.4° C. higher than that of the wild-type D-amino acid transaminase. This substantially enhances its thermal stability, enzymatic activity, etc., effectively broadening its application fields and scope. The mutant has a wide range of industrial applications and thus holds substantial practical value.

Abstract: A method may include acquiring real-time data during rig operations that include rig operations for drilling a borehole in a subsurface geologic region using a drillstring that includes a drill bit, where the drillstring includes stands of drill pipe; based on stand statistics, using at least a portion of the real-time data, calibrating a torque and drag model that models torque and drag of the drillstring in the borehole; based on operation statistics, calling for use of the torque and drag model to make a prediction; and, based at least in part on the prediction, detecting an anomaly.

Abstract: A method may include receiving a digital well plan that specifies planned drilling parameters for drilling a borehole, where each of the specified planned drilling parameters includes one or more of a minimum threshold and a maximum threshold; generating statistical distributions of actual drilling parameters in real-time responsive to receipt of real-time data acquired during a depth-based window for the drilling; generating comparisons in real-time, where each of the comparisons is between one of the statistical distributions and a corresponding one of the planned drilling parameters for the depth-based window; and, responsive to one or more of the comparisons indicating an unacceptable actual to planned parameter deviation, issuing a control signal.

Abstract: A method may include acquiring real-time data during rig operations that include rig operations for drilling a borehole in a subsurface geologic region using a drillstring that includes a drill bit, where the drillstring includes stands of drill pipe; based on stand statistics, using at least a portion of the real-time data, calibrating a torque and drag model that models torque and drag of the drillstring in the borehole; based on operation statistics, calling for use of the torque and drag model to make a prediction; and, based at least in part on the prediction, detecting an anomaly.

Abstract: A method of analyzing flowback of a downhole system includes generating active flowback data by monitoring an active flowback from a wellbore. Historic flowback data for historic flowback from the wellbore is used to determine a flowback cluster. The flowback cluster is selected based on comparing the active flowback data to the historic flowback data and determining one or more data instances of the historic flowback data that have features that are similar to that of the active flowback data. Based on the flowback cluster, one or more thresholds may be determined in order to generate an alert when the active flowback data exceeds the thresholds.

Abstract: A fluid-impervious slide fastener is disposed; an covering abutting member is formed in a central slit of a pair of support tapes, the covering abutting member has a first covering body having a covering layer and a second covering body having a covering layer; when the fluid-impervious slide fastener is in a coupled status, the first covering body and the second covering body are able to elastically abut against each other so as to form a tightening deformation, thus the central slit is provided with a fluid-impervious function against a fluid, for example a liquid, of capable of bearing a hydrostatic pressure of 30 gf/cm2.

Abstract: A fabric having a restraining function is fabricated through at least one yarn having thermoplastic fibers, at least one surface of the fabric has hairiness formed with a plurality of thermoplastic hairs, wherein a first restraining hair having a distal end formed with a spherical member and/or a columnar member is formed through at least a part of the thermoplastic hairs, second restraining hair having a distal end formed with an irregular deformed member is formed through at least a part of the first restraining hairs, so that the at least one surface of the fabric is able to provide a restraining function in a horizontal direction and in a vertical direction to a plurality of fibriform loops.

Abstract: A fluid-impervious slide fastener is disposed; an covering abutting member is formed in a central slit of a pair of support tapes, the covering abutting member has a first covering body having a covering layer and a second covering body having a covering layer; when the fluid-impervious slide fastener is in a coupled status, the first covering body and the second covering body are able to elastically abut against each other so as to form a tightening deformation, thus the central slit is provided with a fluid-impervious function against a fluid, for example a liquid, of capable of bearing a hydrostatic pressure of 30 gf/cm2.

Abstract: A fluid-impervious slide fastener is disposed; an covering abutting member is formed in a central slit of a pair of support tapes, the covering abutting member has a first covering body having a covering layer and a second covering body having a covering layer; when the fluid-impervious slide fastener is in a coupled status, the first covering body and the second covering body are able to elastically abut against each other so as to form a tightening deformation, thus the central slit is provided with a fluid-impervious function against a fluid, for example a liquid, of capable of bearing a hydrostatic pressure of 30 gf/cm2.

Abstract: A method can include providing a trained drilling motor model trained via machine learning based at least in part on drilling motor simulation results; instantiating a motor engine component with an interface in a computational environment; and, responsive to receipt of a call via the interface, returning drilling motor information based at least in part on the trained drilling motor model.

Abstract: A fabric having a restraining function is fabricated through at least one yarn having thermoplastic fibers, at least one surface of the fabric has hairiness formed with a plurality of thermoplastic hairs, wherein a first restraining hair having a distal end formed with a spherical member and/or a columnar member is formed through at least a part of the thermoplastic hairs, second restraining hair having a distal end formed with an irregular deformed member is formed through at least a part of the first restraining hairs, so that the at least one surface of the fabric is able to provide a restraining function in a horizontal direction and in a vertical direction to a plurality of fibriform loops.

Abstract: A fluid-impervious slide fastener is disposed; an covering abutting member is formed in a central slit of a pair of support tapes, the covering abutting member has a first covering body having a covering layer and a second covering body having a covering layer; when the fluid-impervious slide fastener is in a coupled status, the first covering body and the second covering body are able to elastically abut against each other so as to form a tightening deformation, thus the central slit is provided with a fluid-impervious function against a fluid, for example a liquid, of capable of bearing a hydrostatic pressure of 30 gf/cm2.

Abstract: A thermal plastic elastomer injection mold comprises: a mold base, formed with a platform having a top surface thereof formed with an arc-shaped surface adhered with a pair of support-tapes of a slide fastener and formed with an elongated arc-shaped ridge having a wedge-shaped tip thereby being able to be stably moved into a gap between the pair of support-tapes and a surface of the arc-shaped ridge is formed with a thermal plastic elastomer injection port connected to at least one extruder; and a thermal plastic elastomer, extruded out from the at least one extruder and passing the thermal plastic elastomer injection port so as to be injected into the gap and slits inside two rows of coupling elements disposed at inner edges of the pair of support-tapes, wherein the slide fastener is formed with a water impervious structure after the thermal plastic elastomer inside the gap is cut.

Abstract: A method can include receiving well plan information for drilling at least a section of a well at a site; generating a set of candidate drillstring assemblies based at least in part on at least a portion of the well plan information and drillstring assembly component information; generating a proposed set of drillstring assemblies with performance indexes based at least in part on the set of candidate drillstring assemblies and engineering analysis information associated with the site; and generating a final drillstring assembly based at least in part on the proposed set of drillstring assemblies and the performance indexes.

Abstract: A method can include providing a trained drilling motor model trained via machine learning based at least in part on drilling motor simulation results; instantiating a motor engine component with an interface in a computational environment; and, responsive to receipt of a call via the interface, returning drilling motor information based at least in part on the trained drilling motor model.

Abstract: A thermal plastic elastomer injection mold comprises: a mold base, formed with a platform having a top surface thereof formed with an arc-shaped surface adhered with a pair of support-tapes of a slide fastener and formed with an elongated arc-shaped ridge having a wedge-shaped tip thereby being able to be stably moved into a gap between the pair of support-tapes and a surface of the arc-shaped ridge is formed with a thermal plastic elastomer injection port connected to at least one extruder; and a thermal plastic elastomer, extruded out from the at least one extruder and passing the thermal plastic elastomer injection port so as to be injected into the gap and slits inside two rows of coupling elements disposed at inner edges of the pair of support-tapes, wherein the slide fastener is formed with a water impervious structure after the thermal plastic elastomer inside the gap is cut.

Abstract: A fastening fabric having a restraining fabric structure, including a first base structure and plural fiber bundles protruding from a surface of the first base structure, wherein each of the fiber bundles has plural inclined restraining fibers, and the plural inclined restraining fibers are formed with a rigidity and inclined towards a same direction, and respectively formed with an included angle with respect to the surface of the first base structure; and a loop fabric structure, including a second base structure and plural loop bundles protruding from a surface of the second base structure, wherein each of the loop bundles has plural fibriform loops; when the restraining fabric structure and the loop fabric structure are in contact for being mutually adhered, the inclined restraining fibers and the fibriform loops are tangled with each other to provide an adhering and fastening effect.