Abstract: Disclosed are T cell receptors (TCRs) specific for one or more neoantigens and T cells engineered to express said TCRs as well as methods of their use for treating cancer.

Abstract: Disclosed in the present disclosure is a connector assembly, including: an inner conductor, an insulator, an outer conductor and a metal ring, and the outer conductor is disposed around the inner conductor, the insulator is disposed between the inner conductor and the outer conductor, and the metal ring is disposed around at least a portion of an outer periphery of the insulator and is electrically connected to the outer conductor. The structure of the present disclosure enables impedance matching within a Radio Frequency (RF) connector; when the internal structure of the RF connector changes, the impedance of the connector can be adjusted by means of changing the metal ring, so as to prevent the variation of the outer conductor.

Abstract: This invention discloses a method for preparing hexamethylenediamine, which comprises the following steps: (1) under an ammoniation reaction condition, optionally in the presence of a first solvent, subjecting hexanediol and ammonia to an ammoniation reaction to obtain an ammoniation reaction product; (2) separating the ammoniation reaction product from step (1) to obtain a hexamethylenediamine product and heavy components; and (3) under an ammonolysis reaction condition, subjecting the heavy components to ammonolysis to obtain an ammonolysis reaction product, and returning the ammonolysis reaction product to step (2). The invention not only may improve the yield of the hexamethylenediamine, but also may prolong the service life of a catalyst.

Abstract: The present disclosure provides a rack busbar, comprising a housing defining an installation slot. A first busbar and a second busbar are disposed in the installation slot and extend along the length direction. An insulation member is sandwiched between the first busbar and the second busbar in a width direction and extends along the length direction, wherein a top portion of the insulation member in a height direction defines a groove extending along the length direction.

Abstract: Provided are an antibody and use thereof in resisting a tumor. Provided are a single-domain antibody capable of specifically binding to 4-1BB or an antigen-binding fragment thereof, and a multi-specific antibody. The antibody has improved anti-tumor activity and lower liver toxicity.

Abstract: A method and system for controlling position and attitude separation of a tiltable rotorcraft is provided, including a capability prediction module, a position control subsystem, a velocity control subsystem, an attitude angle control subsystem, an angular rate control subsystem, a control allocation module, and a tiltable rotorcraft. After expected position and attitude commands are corrected by the capability prediction module, expected force and torque commands are output by various control subsystems, and after receiving the force and torque commands, the control allocation module is further configured to calculate actual control commands of the aircraft, such as a tilt angle of a rotor assembly and a rotor speed, thus controlling the tiltable rotorcraft to perform the tracking of the expected position and attitude commands.

Abstract: Embodiments of this disclosure can provide a system and method for white balancing images. During operation, the system can obtain labeled red, green, and blue (RGB) image samples captured by a plurality of cameras and generate a plurality of training tasks. A respective training task is associated with RGB image samples captured by a corresponding camera. The system can perform meta-training over the plurality of training tasks to obtain a meta model, with parameters of the meta model optimized based on a global loss function. The system can obtain an image captured by a first camera, fine-tune the meta model using labeled RGB image samples captured by the first camera to obtain a fine-tuned model specific to the first camera, and implement the fine-tuned model to white balance the image.

Abstract: Embodiments of the present disclosure provide a radiotherapy system, comprising a first imaging component, a second imaging component, and a treatment component. The first imaging component and second imaging component may be used to determine a target region of an object and/or to guide an emission of treatment rays. The treatment component may be used to emit the treatment rays toward the target region. An isocenter of the treatment component may coincide with an isocenter of the second imaging component.

Abstract: The present disclosure provides a graphics processing unit, a chip, and an electronic device. The graphics processing unit includes at least two data-and-command dispatchers and at least two graphics processing unit cores, each data-and-command dispatcher is connected to at least one graphics processing unit core, and one of the data-and-command dispatchers is connected to one of the graphics processing unit core through a set of data-and-command transmission lines; The graphics processing unit is configured to provide at least one virtual graphics processing unit, and each virtual graphics processing unit includes one data-and-command dispatcher and some or all of the graphics processing unit cores connected to the data-and-command dispatcher. The graphics processing unit can provide at least one virtual graphics processing unit, and the graphics processing unit can be shared by multiple users in a manner of virtualization of the graphics processing unit.

Abstract: A method for manufacturing a masking film includes forming a molten polymer web that includes at least one polymer, spraying a fluid on one side of the molten polymer web to rapidly cool a random pattern of locations on the one side of the molten polymer web, and cooling the molten polymer web to form the masking film. The masking film includes a plurality of protrusions on one side thereof that correspond to the random pattern of locations on the one side of the molten polymer web contacted by the fluid.

Abstract: Embodiments of this disclosure can provide a camera system. The camera system can include a lens system and a rotatable lens cover protecting the lens system from external environment. The rotatable lens cover can be configured to rotate about an optical axis of the lens system while the camera system is capturing images to reduce artifacts on the captured images caused by contaminants on the rotatable lens cover.

Abstract: Provided are a production line for the rapid hot galvanization of a strip steel, a production line for the rapid annealing of a strip steel, an ultra-short-process production line of an ultrahigh-strength strip steel, a flexible production line suitable for various high-strength strip steels and a dual use production line for the continuous annealing or hot galvanization of a high-strength strip steel. An injection straight fire preheating device, an injection radiant tube preheating device and/or a jet radiation composite heating/soaking device of the present invention are used in the production lines, such that rapid heating can be realized.

Abstract: An integrated air-ground cooperative excitation time-frequency receiving airborne electromagnetic detection system includes a time-frequency receiver, a helicopter airborne time-domain transmitter, a time-frequency receiver coil, and a ground frequency-domain transmitter. The electromagnetic detection method employs synchronized excitation of a time-domain pulsed signal transmitted from the helicopter in air and a frequency-domain continuous wave signal transmitted from the ground, with full airborne reception. Based on frequency point disposition and data decoupling technologies, the electromagnetic detection method enables acquisition of both helicopter airborne time-domain electromagnetic data and ground-air frequency-domain electromagnetic data in a single flight.

Abstract: A wiring harness module and a combined wiring harness, the wiring harness module including a conductor portion and an insulation portion enclosing the conductor portion. The conductor portion includes at least one conductor, each of which is connected to at least one input conductive connector and at least one output conductive connector. An electrical connection of the conductors of different wiring harness modules is realized by connecting the input conductive connector and the output conductive connector of the different wiring harness modules. The combined wiring harness is formed by splicing a plurality of wiring harness modules in accordance with a preset splicing manner, and the conductors of the plurality of wiring harness modules being electrically connected to each other via the input conductive connector and the output conductive connector. In the present disclosure a complex conductive circuit is combined.

Abstract: Example methods and systems for enhanced accent conversion are provided. In an example method, an audio input is accessed and a first set of features is extracted from the audio input using a first neural network. A second set of features is further determined based on the first set of features using a second neural network. The second neural network is configured to extract features that are accent-neutral. The second set of features is then transformed into output audio data using a decode based on a designated accent identifier. The example method provides an enhanced accent conversion for video conferencing and audio recording.

Abstract: A circuit board includes two first circuit substrates, two second circuit substrates, a magnetic assembly, a first component, and a second component. The first circuit substrate includes a first coil. Two second circuit substrates are disposed between the two first circuit substrates and electrically connects the two first circuit substrates. The second circuit substrate includes a second coil. Two grooves are defined on second circuit substrate. The magnetic assembly is disposed between the two first circuit substrates and between the two second circuit substrates. The magnetic assembly includes a magnetic member. The first circuit substrate can be bent by an interaction of a magnetic field generated by the magnetic assembly and a magnetic field generated by the first coil or the second coil. The present disclosure further provides method for manufacturing the circuit board and a terminal device.

Abstract: An injection molded wire harness and a molding method. The wire harness includes a terminal and at least one conductor. One end of the terminal is connected to an electrical circuit of an electrical device, and the other end of the terminal is connected to the conductor. The wire harness is provided with a protective layer which is injection-molded and wraps the conductor, and at least one positioning device that is injection molded for fixing the position of the wire harness and/or at least one sealing device that is injection molded for waterproofing. The method can reduce manual operation, improve consistency of wire harness products, reduce production cost of wire harness products, and prolong the service life of the wire harness.

Abstract: A cartridge preprocessing system applied to an automated molecular diagnostics instrument is provided. The cartridge preprocessing system includes a piercing device and a cleaning device. The piercing device includes a drive assembly and a piercing member, and the drive assembly is configured to control the piercing member to alternately move to a piercing station and a cleaning station. The piercing member is configured to pierce a barrier film of a cartridge that moves to the piercing station, and the cleaning device is configured to clean the piercing member that moves to the cleaning station.

Abstract: Related is a single-domain antibody targeting 4-1BB, a fusion protein thereof, a pharmaceutical composition and a use thereof. Specifically, the related single-domain antibody comprises one heavy chain variable region, and the amino acid sequences of CDR1-CDR3 contained in the heavy chain variable region are as shown in any item in table B, respectively. The single-domain antibody can bind to human 4-1BB and at the same time cross-bind to cynomolgus 4-1BB; in addition, with the help of external cross-linking, T cells are activated, which have excellent anti-tumor activity and safety.

Abstract: A display substrate and a display apparatus are provided. The display substrate includes data lines, gate lines, a semiconductor layer, and transistors. The semiconductor layer is located between the gate lines and the data lines; each transistor includes a gate electrode, an active layer, a first electrode, and a second electrode, the semiconductor layer includes the active layer. The gate lines are located on a side of the data lines away from the base substrate, the gate electrode is disposed in the same layer as the data lines, the semiconductor layer includes a semiconductor portion laminated with the gate lines, and the semiconductor portion is spaced apart from the active layer, and the display substrate includes a light shielding portion in the same layer as the data lines, and overlapped with the semiconductor portion.