Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Abstract: A cable connector assembly includes a cable and an electrical connector electrically connected with the cable, and the electrical connector includes a mating member, a printed circuit board electrically connected with the mating member, a light emitting element electrically connected with the printed circuit board and a light guide element for transmitting the light emitted by the light emitting element, having a receiving room, wherein the light emitting element is received in the receiving room, and the printed circuit board includes a soldering portion electrically connected with the matting member and an extension portion rearwardly extending from the soldering portion, and the cable connector assembly further includes a stopping member disposed between the soldering portion and the light guide element and abutting against the light guide element, to block the receiving room of the light guide element.

Abstract: A cable connector assembly includes an insulative housing, a number of contacts retained in the insulative housing, a printed circuit board electrically connected with at least some of the contacts, a cable electrically connected with the contacts and the printed circuit board, an insulative member enclosing the printed circuit board, and a shielding case enclosing the insulative housing and the insulative member, wherein the insulative member includes a recess portion spaced from the shielding case.

Abstract: A method for controlling a resonant DC/DC power converting circuit is provided. The resonant DC/DC power converting circuit having a converter output and a converter input comprises at least two converters having similar structures and outputs connected in parallel as said converter output, and a controller. Each converter comprises a full-bridge inverter unit and a resonant unit. The full-bridge inverter unit is configured with at least four switches. The resonant unit is coupled with said full-bridge inverter unit. The controller outputs two groups of driving control signals to drive four switches in said two converters respectively. The method comprises: making said two converters operate at the same frequency and interleave with preset phase shift; and making two of driving control signals in one group interleave with preset angle to reduce output current of said converter corresponding controlled thereby, when output currents of said two converters are not approximately equal.

Abstract: A control method for a power converter is provided. The power converter includes an inductor, and a switch selectively turned on according to a control signal. The control method includes determining an on-time and a falling time according to a voltage information or a current information of the power converter; determining a switching period of the control signal according to the on-time, the falling time, and a resonant period corresponding to the inductor and a parasitic capacitance of the switch; adjusting the switching period by comparing the switching period with a first threshold period and a second threshold period; generating the control signal having the switching period when the switching period is greater than the first threshold period and less than the second threshold period or when the switching period is greater than the second threshold period and the power converter operates at over 50% of a rated power.

Abstract: The present application discloses a device for wireless charging circuit, comprising: a primary circuit box, which comprises at least one first switch unit; a secondary circuit box, which comprises at least one second switch unit; a transmission plate, which comprises a primary inductor of a transformer and a primary compensation capacitor, the primary inductor being coupled in series with the primary compensation capacitor; a receiving plate, which comprises a secondary inductor of the transformer; the transmission plate and the receiving plate are magnetically coupled with each other; the transmission plate is coupled with the primary circuit box; and the receiving plate is coupled with the secondary circuit box. The voltage between external terminals of transmission plate and the voltage between external terminals of receiving plate can satisfy the safety requirement.

Abstract: A switch power converter and method of testing and adjusting is provided. A switch power unit comprises at least a power switch for transform of the power. A controller is configured to generate a control signal for the power switch. A detector is configured to detect an output voltage signal and/or an output current signal of the switch power unit and output a sampling signal. A testing and adjusting unit is configured to receive the sampling signal and output a testing signal to the controller. The testing and adjusting unit comprises a compensator. The compensator attends the testing and adjusting of the switch power converter.

Abstract: A magnetic structure includes at least one bobbin and a core. Each of the bobbin has at least one winding portion in which a through passage is provided along its longitudinal direction, the core has at least one column, the column is received in the through passage so that a heat dissipation space is formed between an outer wall of the column and an inner wall of the through passage. In the magnetic structure according to the present disclosure, during the operation of the magnetic structure, the heat generated from the column and from an inner layer of a coil wound on the winding portion both can be quickly dissipated through the heat dissipation space, and thus the heat dissipation efficiency of the magnetic structure according to the present disclosure is improved.

Abstract: A fully automated high-precision capillary electrophoresis instrument, comprising an electrophoresis system, a sample injection flow path, and an automatic sampling flow path; the sampling flow path comprising a shunt waste bottle, which is connected to a four-way connector, a four-way sample injection valve and a buffer syringe pump; the automatic sampling flow path comprises a sampling needle, a sample tray, a cleaning tank, reagent bottles, a buffer tube, a six-channel liquid dispenser, and a syringe pump. The described capillary electrophoresis instrument has a fast sample injection speed, high accuracy, good reproducibility, and can be widely used in automated analysis of different substances by capillary electrophoresis.

Abstract: The present application discloses a power converter and a controlling method thereof. The power converter at least comprises an inductor, a parasitic capacitor, an energy storage switch and a free-wheeling switch, and the controlling method is used for enabling the energy storage switch to maintain zero-voltage turn-on during the normal operation of the power converter. The controlling method comprising: within a switching period, the free-wheeling switch is turned on again for a preset time after the free-wheeling switch is turned on and turned off for the first time and after the inductor and the parasitic capacitor resonate, so that a voltage between two terminals of the energy storage switch can decline to zero, and when the voltage between two terminals of the energy storage switch declines to zero, the energy storage switch is turned on, thereby entering the next switching period of the power converter.

Abstract: A cable connector assembly includes a cable and an electrical connector electrically connected with the cable, and the electrical connector includes a mating member, a printed circuit board electrically connected with the mating member, a light emitting element electrically connected with the printed circuit board and a light guide element for transmitting the light emitted by the light emitting element, having a receiving room, wherein the light emitting element is received in the receiving room, and the printed circuit board includes a soldering portion electrically connected with the matting member and an extension portion rearwardly extending from the soldering portion, and the cable connector assembly further includes a stopping member disposed between the soldering portion and the light guide element and abutting against the light guide element, to block the receiving room of the light guide element.

Abstract: A power converting circuit includes a converter. The converter receives and converts an input power to provide power for a load. The converter includes a power storage unit, a switch unit, a capacitor unit, and a current sampling unit. The power storage unit includes input and output terminals. The switch unit includes first and second switches, which are series connected at a common terminal, and the common terminal is coupled to the output terminal of the power storage unit. The capacitor unit includes first and second capacitors. The first capacitor and the switch unit are parallel connected to form a capacitor-switch parallel structure. The second capacitor capacitance is more than ten times larger than the first capacitor capacitance. The current sampling unit and the capacitor-switch parallel structure are series connected to form a capacitor-sampling unit series structure. The capacitor-sampling unit series structure and the second capacitor are parallel connected.

Abstract: The present invention is directed generally to systems and methods suitable for high level expression of recombinant proteins in suspension CHO cells. In particular, the invention allows introduction of the invention obviates the need to replace, replenish or supplement the growth medium during the procedure. The invention also relates to compositions and kits useful for culturing and transforming/transfecting suspension CHO cells.

Abstract: A cable connector assembly includes an insulative housing, a number of contacts retained in the insulative housing, a printed circuit board electrically connected with at least some of the contacts, a cable electrically connected with the contacts and the printed circuit board, an insulative member enclosing the printed circuit board, and a shielding case enclosing the insulative housing and the insulative member, wherein the insulative member includes a recess portion spaced from the shielding case.

Abstract: A control method of an inverter circuit includes the following steps. Firstly, a half cycle of the AC output voltage is divided into a first stage and a second stage. Then, the upper switch element and the lower switch element are controlled to be operated at a first switching frequency lower than a preset threshold frequency in the first stage, so that the inverter circuit is operated in a continuous current mode. Then, the upper switch element or the lower switch element of the bridge arm is controlled to be operated at a second switching frequency in the second stage, so that the upper switch element and the lower switch element are turned on at a preset voltage level and the inverter circuit is operated at a discontinuous current mode boundary mode.

Abstract: A method of providing content includes acquiring user profile information from an image of a user of an electronic apparatus configured to provide content to the user, acquiring context information from a surrounding environment of the electronic apparatus, and providing content to the user based on the user profile information and the context information.

Abstract: A sheath flow device for an evaporation light scattering detector comprises an evaporation pipe fastener (110), an evaporation pipe heat insulating component (120), a sheath flow nozzle blocking plate (130), a sheath flow nozzle (140), a sheath flow sleeve (150), a sheath flow outlet piece (170) and a stainless steel spray needle (160). The evaporation pipe fastener, the evaporation pipe heat insulating component, the sheath flow nozzle blocking plate, the sheath flow nozzle, the sheath flow sleeve and the sheath flow outlet piece are concentrically connected orderly from front to back, and all provided with concentric inner holes. Said device is applicable to ELSD sheath flow devices ranging from nanoliter-scale to microliter-scale.

Abstract: A power converter device, includes switching devices and a controller, to realize conversion between power supplies by controlling on and off the switching devices via the controller. The switching devices include: at least one normally-on type switching device and at least one normally-off type switching device both having an operation frequency greater than 1 kHz and connected in series. The controller outputs a first and second control signal to correspondingly control the normally-on type switching device and the normally-off type switching device to control the normally-off type switching device to be turned on after the normally-on type switching device to be turned off. The present disclosure uses the normally-off type switching device originally disposed in the circuit, having a voltage blocking ability, to realize directly usage of the normally-on type switching device to improve efficiency and power density of switching power supply.

Abstract: The present application discloses a power converter and a controlling method thereof. The power converter at least comprises an inductor, a parasitic capacitor, an energy storage switch and a free-wheeling switch, and the controlling method is used for enabling the energy storage switch to maintain zero-voltage turn-on during the normal operation of the power converter. The controlling method comprising: within a switching period, the free-wheeling switch is turned on again for a preset time after the free-wheeling switch is turned on and turned off for the first time and after the inductor and the parasitic capacitor resonate, so that a voltage between two terminals of the energy storage switch can decline to zero, and when the voltage between two terminals of the energy storage switch declines to zero, the energy storage switch is turned on, thereby entering the next switching period of the power converter.

Abstract: A connector assembly includes a housing, a metal shell, plural terminals, a cable, an inner member, and an outer boot. The inner member comprises a dispensing groove and at least one receiving groove, and a bonding material is received in the dispensing groove and in one or more of the at least one receiving groove. A method of manufacturing a connector assembly comprises the steps of: providing a housing; soldering a cable to the housing; enclosing a metal shell to cover the housing; molding an inner member on cable to comprise a dispensing groove and at least one receiving groove behind the dispensing groove; setting an outer boot along a front-to-back direction onto the metal shell; and depositing a bonding material in the dispensing groove and pushing the outer boot forwardly across the dispensing groove and the at least one receiving groove until covering the whole inner member.