Patents by Inventor Chao-Yang LAI

Chao-Yang LAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of stimulating TLR9-activated immune response
    Patent number: 10337017
    Abstract: A method of stimulating a TLR9-activated immune response or enhancing a TLR9-activated immune response to an antigen is disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, the method of stimulating TLR9-activated immune response by administering an effective amount of immunogenic composition comprising an antigen and a CpG-ODN comprising GACGTT or AACGTT motif was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: July 2, 2019
    Assignee: National Health Research Institutes
    Inventors: Tsung-Hsien Chuang, Chao-Yang Lai
  • CpG-OLIGODEOXYNUCLEOTIDE, IMMUNOGENIC COMPOSITION INCLUDING THE SAME, AND METHOD OF INDUCING IMMUNE RESPONSE BY THE SAME
    Publication number: 20190100756
    Abstract: A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host is provided. The CpG-ODN includes one or more copies of the sequences of GTCGTT, one or more copies of the sequences of GTT and one or more copies of the sequences of TTTT, wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT. Further, an immunogenic composition including the CpG-ODN and a method of inducing immune response by the same are also provided.
    Type: Application
    Filed: October 2, 2017
    Publication date: April 4, 2019
    Inventors: Tsung-Hsien CHUANG, Da-Wei YEH, Chao-Yang LAI, Yi-Ling LIU, Chih-Hao LU
  • CpG-oligodeoxynucleotide, immunogenic composition including the same, and method of inducing immune response by the same
    Patent number: 10246715
    Abstract: A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host is provided. The CpG-ODN includes one or more copies of the sequences of GTCGTT, one or more copies of the sequences of GTT and one or more copies of the sequences of TTTT, wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT. Further, an immunogenic composition including the CpG-ODN and a method of inducing immune response by the same are also provided.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: April 2, 2019
    Assignee: National Health Research Institutes
    Inventors: Tsung-Hsien Chuang, Da-Wei Yeh, Chao-Yang Lai, Yi-Ling Liu, Chih-Hao Lu
  • METHOD OF STIMULATING TLR9-ACTIVATED IMMUNE RESPONSE
    Publication number: 20180135053
    Abstract: A method of stimulating a TLR9-activated immune response or enhancing a TLR9-activated immune response to an antigen is disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, the method of stimulating TLR9-activated immune response by administering an effective amount of immunogenic composition comprising an antigen and a CpG-ODN comprising GACGTT or AACGTT motif was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.
    Type: Application
    Filed: December 29, 2017
    Publication date: May 17, 2018
    Inventors: Tsung-Hsien CHUANG, Chao-Yang LAI
  • CpG-OLIGODEOXYNUCLEOTIDE, IMMUNOGENIC COMPOSITION COMPRISING THE SAME, AND METHODS FOR PREPARING THE COMPOSITION AND STIMULATING IMMUNE RESPONSE THEREBY
    Publication number: 20160168571
    Abstract: CpG-oligodeoxynucleotides (CpG-ODN), as potent immune stimuli developed for using as adjuvant in different species, are disclosed herein. TLR9 is the cellular receptor for CpG-ODN, and current developed CpG-ODN has low activity to rabbit TLR9. Here, a type of CpG-ODN containing a GACGTT or AACGTT motif in about 11-14 deoxynucleotides was demonstrated to have potent immunostimulatory activity to rabbit TLR9, and capable of boosting a less toxic and potent antibody response in rabbits.
    Type: Application
    Filed: July 18, 2014
    Publication date: June 16, 2016
    Applicant: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Tsung-Hsien CHUANG, Chao-Yang LAI