Patents by Inventor Chao-Yie Yang

Chao-Yie Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BET bromodomain inhibitors and therapeutic methods using the same
    Patent number: 10391175
    Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: August 27, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Xu Ran, Yujun Zhao, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachern, Jeanne Stuckey, Jennifer Lynn Meagher, Duxin Sun, Xiaoqin Li, Bing Zhou, Hacer Karatas, Ruijuan Luo, Arul Chinnaiyan, Irfan A. Asangani
  • BET PROTEIN DEGRADERS
    Publication number: 20190169195
    Abstract: The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein B, R1, R5, Q1, Q?, L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provids compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.
    Type: Application
    Filed: April 6, 2017
    Publication date: June 6, 2019
    Inventors: Shaomeng Wang, Bing Zhou, Fuming Xu, Jiantao Hu, Longchuan Bai, Chao-Yie Yang
  • MONOFUNCTIONAL INTERMEDIATES FOR LIGAND-DEPENDENT TARGET PROTEIN DEGRADATION
    Publication number: 20190119289
    Abstract: The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.
    Type: Application
    Filed: April 6, 2017
    Publication date: April 25, 2019
    Inventors: Shaomeng Wang, Yangbing Li, Angelo Aguilar, Bing Zhou, Jiantao Hu, Fuming Xu, Chong Qin, Yang Hu, Weiguo Xiang, Rohan Rej, Jiuling Yang, Xin Han, Longchuan Bai, Chao-Yie Yang
  • Indoloquinolone compounds as anaplastic lymphoma kinase (ALK) inhibitors
    Patent number: 9783539
    Abstract: Disclosed herein are certain indoloquinolone compounds, methods of preparation thereof, pharmaceutical compositions thereof, and uses thereof, such as their uses as ALK inhibitors.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: October 10, 2017
    Assignee: Jiangsu Ascentage Biomed Development Inc.
    Inventors: Jianyong Chen, Yunlong Zhou, Shaomeng Wang, Ming Guo, Dajun Yang, Lingling Jiao, Yu Jing, Xu Qian, Liu Liu, Longchuan Bai, Chao-Yie Yang, Donna McEachern
  • BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
    Publication number: 20170281773
    Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
    Type: Application
    Filed: June 12, 2017
    Publication date: October 5, 2017
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Xu Ran, Yujun Zhao, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachern, Jeanne Stuckey, Jennifer Lynn Meagher, Duxin Sun, Xiaoqin Li, Bing Zhou, Hacer Karatas, Ruijuan Luo, Arul Chinnaiyan, Irfan A. Asangani
  • BET bromodomain inhibitors and therapeutic methods using the same
    Patent number: 9675697
    Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 13, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Xu Ran, Yujun Zhao, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachern, Jeanne Stuckey, Jennifer Lynn Meagher, Duxin Sun, Xiaoqin Li, Bing Zhou, Hacer Karatas, Ruijuan Luo, Arul Chinnaiyan, Irfan A. Asangani
  • INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS
    Publication number: 20170066761
    Abstract: Disclosed herein are certain indoloquinolone compounds, methods of preparation thereof, pharmaceutical compositions thereof, and uses thereof, such as their uses as ALK inhibitors
    Type: Application
    Filed: February 27, 2014
    Publication date: March 9, 2017
    Applicant: Jiangsu Ascentage Biomed Development Inc.
    Inventors: Jianyong CHEN, Yunlong ZHOU, Shaomeng WANG, Ming GUO, Dajun YANG, Lingling JIAO, Yu JING, Xu QIAN, Liu LIU, Longchuan BAI, Chao-Yie YANG, Donna MCEACHERN
  • BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
    Publication number: 20140256706
    Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 11, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Xu Ran, Yujun Zhao, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachern, Jeanne Stuckey, Jennifer Lynn Meagher, Duxin Sun, Xiaoqin Li, Bing Zhou, Hacer Karatas, Ruijuan Luo, Arul Chinnaiyan, Irfan A. Asangani
  • Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same
    Patent number: 8691184
    Abstract: Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: April 8, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haibin Zhou, Jianfang Chen, Angelo Aguilar, Jennifer L. Meagher, Duxin Sun, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachem, Jeanne Stuckey, Xiaoqin Li
  • BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
    Publication number: 20120189539
    Abstract: Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
    Type: Application
    Filed: January 24, 2012
    Publication date: July 26, 2012
    Applicant: THE REGENTS OF UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Haibin Zhou, Jianfang Chen, Angelo Aguilar, Jennifer L. Meagher, Duxin Sun, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachem, Jeanne Stuckey, Xiaoqin Li
  • Conformationally constrained Smac mimetics and the uses thereof
    Patent number: 7932382
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: April 26, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu
  • SMAC Peptidomimetics and the Uses Thereof
    Publication number: 20100093645
    Abstract: The invention relates to peptidomimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these peptidomimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: January 18, 2005
    Publication date: April 15, 2010
    Inventors: Shaomeng Wang, Halying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, Jlanyong Chen
  • Conformationally constrained Smac mimetics and the uses thereof
    Patent number: 7674787
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: March 9, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, Naoyuki G. Saito, Jianyong Chen
  • Conformationally Constrained Smac Mimetics and the Uses Thereof
    Publication number: 20080269140
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: January 18, 2005
    Publication date: October 30, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu
  • Conformationally Constrained Smac Mimetics And The Uses Thereof
    Publication number: 20080132485
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: July 11, 2005
    Publication date: June 5, 2008
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovksa-Coleska, Chao-Yie Yang, Liang Xu, Naoyuki G. Saito, Jianyong Chen
  • Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof
    Publication number: 20060247305
    Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: March 13, 2006
    Publication date: November 2, 2006
    Applicant: Regents of the University of Michigan
    Inventors: Shaomeng Wang, Ke Ding, Guozhi Tang, Zaneta Nikolovska-Coleska, Renxio Wang, Chao-Yie Yang
  • Method for savings in nuclear reactors by using beryllium rods in fuel bundles
    Patent number: 4148687
    Abstract: Nuclear fuels in the form of rod bundle with one or several beryllium rods inserted therein are proposed for use in power reactors positioned to obtain reactivity increase in order to save the D.sub.2 O inventory in a heavy water reactor or to relax the requirement of uranium enrichment if used in light water reactors.
    Type: Grant
    Filed: August 26, 1976
    Date of Patent: April 10, 1979
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ji-Peng Chien, Chao-Yie Yang, Horng-Ming Hsich
  • Utilization of heavy elements in thermal and epithermal reactors
    Patent number: 4123328
    Abstract: Increases in reactivity can be obtained in thermal and epithermal reactors by utilization of heavy elements in selected locations in the reactors. These increases can result in economic gains, for example, in reduction in the amounts of heavy water needed in heavy water moderated reactors and in reduction of the enrichment needed in light water reactors. A number of examples are provided of advantageous use of the heavy elements in specific reactor embodiments.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: October 31, 1978
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council
    Inventors: Alvin Radkowsky, Ji-Peng Chien, Chao-Yie Yang, Horng-Ming Hsieh