Abstract: Provided herein is a method of treating cancer in a human subject, comprising administering to the subject an antibody-drug conjugate (ADC) comprising an antibody or antigen-binding fragment thereof which specifically binds human claudin 18.2 and monomethyl auristatin E, wherein the subject is administered at least one dose of the ADC of about 0.3 to about 3.4 mg/kg.

Abstract: This disclosure describes a non-volatile storage device includes a non-volatile storage and a controller. The controller includes a data evaluator to evaluate each block of data stored in the non-volatile storage, the evaluation being made in accordance with multiple integrity factors; a factor evaluator to provide a weight to each of the multiple integrity factors for each of the multiple blocks of data, aggregate the multiple weighted integrity factors for each of the multiple blocks of data, and identify one of the multiple blocks of data stored in the non-volatile storage for which the aggregated weight integrity factors is highest; and a scanner to perform at least one media scan of the identified block of data stored in the non-volatile storage, e.g., NAND flash memory.

Abstract: The present application relates to the use of an antibody-drug conjugate, and a combined drug and the use thereof. Specifically provided are the use of an antibody-drug conjugate, a combined drug and the use thereof. The antibody-drug conjugate shows a significant pharmacodynamic effect of inhibiting tumor cell growth in various NSCLC cell lines with EGFR mutation expression and various human NSCLC PDX tumor models of AZD9291 drug resistance with EGFR mutation expression. In addition, the combined administration of the antibody-drug conjugate and an anti-PD-1 antibody or an anti-PD-L1 antibody shows a significant synergistic pharmacodynamic effect of inhibiting tumor cell growth in the human NSCLC PDX tumor model of AZD9291 drug resistance with EGFR mutation expression.

Abstract: A method for adaptive mapping for data compression includes determining an input/output (I/O) request pattern, dynamically switching between a segment mapping mode and a flat hash table mapping mode based on the determined I/O request pattern, updating a shared mapping table for the segment mapping mode and the flat hash table mapping mode, and adjusting an entry of the mapping table based on the determined I/O request pattern and a status of the entry.

Abstract: A method of operating a computing system comprises defining a zoned namespace for non-volatile memory (NVM) of a memory device of the computing system, the zoned namespace including multiple NVM zones of multiple non-overlapping logical block addresses (LBAs) of the NVM, mapping persistence logging (PLOG) identifiers (IDs) to the NVM zones, a PLOG ID identifying a PLOG zone of one or more NVM zones, and performing a PLOG-specific access operation on a PLOG zone of the NVM in response to a PLOG-specific command received from a host device of the computing system.

Abstract: This invention is directed to managing data storage in a memory system. The memory system receives a host request for an erase operation on a first erasable unit of a first memory block. In response to the host request, the memory system identifies an unused erasable unit of a second memory block in the memory system, remaps the first erasable unit of the first memory block to the unused erasable unit of the second memory block, and applies the erase operation on the unused erasable unit of the second memory block in place of the first erasable unit of the first memory block. In some embodiments, at a time of receiving the host request, the memory system further includes a space reserve of over-provisioning, and the second memory block is different from the space reserve. In some embodiments, the second memory block is moved offline to join the space reserve.

Abstract: Write operation and garbage collection methods are provided for a Solid State Drive (SSD) controller of a SSD having Not-AND (NAND) flash memory devices with on-die Static Random Access Memory (SRAM) and NAND flash memory. In the write operation method, a received block of data is stored in on-die SRAM of the NAND flash device, rather than in on-chip SRAM of the controller, prior to programming into NAND flash memory. Until programmed into NAND flash memory, the block of data remains available in the on-die SRAM to fulfill an ‘immediate read’ operation, if received. In the garbage collection method, blocks of data are read from one or more source NAND flash devices and stored in on-die SRAM of a destination NAND flash device until a limit of such blocks has been reached, then the destination NAND flash device programs the blocks from the on-die SRAM into NAND flash memory.

Abstract: This document provides methods and materials for treating a mammal having HER2-expressing cancers. For example, antibody drug conjugates containing an anti-HER2 antibody and at least one molecule of an anti-cancer drug are provided, as well as methods of administering such antibody drug conjugates to a mammal (e.g., a human) having a HER2-expressing cancer to treat the mammal.

Abstract: This application is directed to storing data by distributing redundant data blocks across multiple memory devices (e.g., solid-state drives (SSDs)) and based on multiple RAID schemes. An electronic system mirrors user data on two distinct memory devices. Integrity data is generated based on the user data and stored on an integrity memory device. In accordance with a determination that the integrity data of the user data is stored on the integrity memory device, the electronic system releases the user data mirrored on at least one of the two distinct memory devices. In some embodiments, a copy of the user data is also stored on one of a plurality of data memory devices. The integrity data is generated based on the user data and stored on the integrity memory device, in accordance with a determination that the plurality of data memory devices is filled.

Abstract: The present invention relates to an antibody-drug conjugate and an application thereof, and specifically provides the antibody-drug conjugate, a pharmaceutically acceptable salt and solvate thereof, or a solvate of the salt. The antibody-drug conjugate has the structure represented by formula I, wherein Ab is an anti-Claudin 18.2 antibody. The antibody-drug conjugate of the present invention has good tumor cell growth inhibition activity in vivo and in vitro, low toxicity, and good application prospects.

Abstract: Systems and methods for space allocation for block device compression are provided. In particular, a computing device may receive an allocation request to write the compressed data, select a range list adequate for serving the allocation request from a plurality of range list, dequeue a range entry from the selected range list to allocate free space for the compressed data, and allocate the free space corresponding to the range entry to the compressed data to serve the allocation request.

Abstract: The present disclosure describes techniques of metadata management for transparent block level compression. A first area may be created in a backend solid state drive. The first area may comprise a plurality of entries. The plurality of entries may be indexed by addresses of a plurality of blocks of uncompressed data. Each of the plurality of entries comprises a first part configured to store metadata and a second part configured to store compressed data. Each of the plurality blocks of uncompressed data may be compressed individually to generate a plurality of compressed blocks. Metadata and at least a portion of compressed data associated with each of the plurality of compressed blocks may be stored in one of the plurality of entries based on an address of a corresponding block of uncompressed data. A second area may be created in the backend solid state drive for storing the rest of the compressed data.

Abstract: A system and method are described to efficiently allocate memory space with low latency overhead by allocating blocks of non-volatile memory on a storage device according to a tree data structure comprising a plurality of counter sets, each counter set including one or a plurality of counters indicating numbers of unallocated blocks of memory space within the non-volatile memory.

Abstract: The present invention provides an antibody drug conjugate formulation, comprising an antibody drug conjugate or a salt thereof, a citric acid buffer solution, trehalose, sodium chloride and polysorbate 80. The antibody drug conjugate has a structure represented by Ab-(L-D)p, wherein Ab represents an anti-epidermal growth factor receptor antibody, L represents a linker, and D represents a cytotoxic agent.

Abstract: This document provides methods and materials for treating a mammal having HER2-expressing cancers. For example, antibody drug conjugates containing an anti-HER2 antibody and at least one molecule of an anti-cancer drug are provided, as well as methods of administering such antibody drug conjugates to a mammal (e.g., a human) having a HER2-expressing cancer to treat the mammal.

Abstract: Described are examples for storing data on a storage device, including storing, in a live write stream cache, one or more logical blocks (LBs) corresponding to a data segment, writing, for each LB in the data segment, a cache element of a cache entry that points to the LB in the live write stream cache, where the cache entry includes multiple cache elements corresponding to the multiple LBs of the data segment, writing, for the cache entry, a table entry in a mapping table that points to the cache entry, and when a storage policy is triggered for the cache entry, writing the multiple LBs, pointed to by each cache element of the cache entry, to a stream for storing as contiguous LBs on the storage device, and updating the table entry to point to a physical address of a first LB of the contiguous LBs on the storage device.

Abstract: Systems and methods for accessing block storage devices are provided. In particular, a computing device may receive a write request including an uncompressed data and an uncompressed block address associated with the uncompressed data, generate compressed data by compressing the uncompressed data, determine a plurality of mapping candidates of compressed data blocks in the block storage devices based on the uncompressed block address, select a compressed data block from the plurality of mapping candidates that has sufficient capacity to store the compressed data, write the compressed data to the selected compressed data block, update metadata of the selected compressed data block to link the uncompressed block address to a compressed block address of the selected compressed data block, and write the selected compressed data block back to a respective block storage device of the block storage devices.

Abstract: A flat hash table includes a plurality of entries, and each entry includes a hash function index and a usage bitmap. A method for block device level compression mapping using the flat hash table includes compressing uncompressed data to compressed data, retrieving an entry of the flat hash table using an uncompressed block address of the uncompressed data, determining a compressed block address of the compressed data by executing at least one hash function and by determining a hash function in the at least one hash function for mapping the uncompressed block address to the compressed block address that corresponds to a space in a block storage device, storing the compressed data to the space that corresponds to the compressed block address, and updating the hash function index of the entry of the flat hash table with an index indicative of the hash function.

Abstract: Described are examples for storing, in a first zone cache, one or more logical blocks (LBs) corresponding to a data chunk, writing, for each LB in the data chunk, a cache element of a cache entry that points to the LB in the first zone cache, where the cache entry includes multiple cache elements corresponding to the multiple LBs of the data chunk, writing, for the cache entry, a table entry in a mapping table that points to the cache entry, and when a storage policy is triggered for the cache entry, writing the multiple LBs, pointed to by each cache element of the cache entry, as contiguous LBs in an isolation block for the data chunk in a second zone stream, and updating the table entry to point to the isolation block in the second zone stream.

Abstract: Described are examples for storing data on a storage device, including storing, in a live write stream cache, one or more logical blocks (LBs) corresponding to a data segment, writing, for each LB in the data segment, a cache element of a cache entry that points to the LB in the live write stream cache, where the cache entry includes multiple cache elements corresponding to the multiple LBs of the data segment, writing, for the cache entry, a table entry in a mapping table that points to the cache entry, and when a storage policy is triggered for the cache entry, writing the multiple LBs, pointed to by each cache element of the cache entry, to a stream for storing as contiguous LBs on the storage device, and updating the table entry to point to a physical address of a first LB of the contiguous LBs on the storage device.