Patents by Inventor Chaojun GONG

Chaojun GONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230090060
    Abstract: The present disclosure provides the synthesis and application of respiratory syncytial virus inhibitor, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer, solvate, prodrug or isotope label thereof. Compared with the existing inhibitors, the compounds of formula I have the advantages of superior activity and higher exposure in vivo.
    Type: Application
    Filed: January 21, 2021
    Publication date: March 23, 2023
    Inventors: Cheng PENG, Xiashi LV, Mengfei QIAN, Wei YIN, Chaojun GONG, Jian HAN, Wei SHEN, Danbin LI, Gang ZOU, Haiqing YUAN, Zhen Jim WU
  • Publication number: 20220081434
    Abstract: The present disclosure provides a series of dihydroisoquinoline compounds or a pharmaceutically acceptable salt, ester, isomer, solvate, hydrate, prodrug, or isotopically labeled compounds thereof, having the structure of general formula I: (I). The compounds have an extremely strong activity for inhibiting Hepatitis B surface antigen and has an extremely strong activity for inhibiting Hepatitis B virus DNA. In addition, the compounds feature high bioavailability and can exhibit efficacy with a low dosage, which reduces the potential toxicity of the compounds.
    Type: Application
    Filed: January 7, 2020
    Publication date: March 17, 2022
    Inventors: Cheng PENG, Shaoyun ZHANG, Xiaogang LAI, Chaojun GONG, Jian HAN, Baolin XU, Gang ZOU, Danbin LI, Haiqing YUAN, Zhen Jim WU
  • Patent number: 10766889
    Abstract: The invention describes an aryl-2,2?-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2?-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: September 8, 2020
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Fajun Nan, Jia Li, Jian Ding, Meiyu Geng, Yangming Zhang, Yi Chen, Yubo Zhou, Chaojun Gong, Mingbo Su, Anhui Gao
  • Patent number: 10647712
    Abstract: A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: May 12, 2020
    Assignee: SUZHOU ARK BIOPHARMACEUTICAL CO., LTD.
    Inventors: Cheng Peng, Qing Xu, Teng Feng, Xiashi Lv, Xiaogang Lai, Rui Cui, Shaoyun Zhang, Jian Han, Chaojun Gong, Zhaoxiong Cai, Yang Zhou, Gang Zou, Danbin Li, Haiqing Yuan, Zhen Jim Wu
  • Publication number: 20190389855
    Abstract: A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.
    Type: Application
    Filed: January 10, 2018
    Publication date: December 26, 2019
    Inventors: Cheng PENG, Qing XU, Teng FENG, Xiashi LV, Xiaogang LAI, Rui CUI, Shaoyun ZHANG, Jian HAN, Chaojun GONG, Zhaoxiong CAI, Yang ZHOU, Gang ZOU, Danbin LI, Haiqing YUAN, Zhen Jim WU
  • Publication number: 20190211005
    Abstract: The invention describes an aryl-2,2?-tandem bisthiazole compound and a preparation method and the use thereof. In particular, disclosed in the present invention are an aryl-2,2?-tandem bisthiazole compound with the structure as shown in general formula I and the preparation method thereof and use thereof as a histone deacetylase inhibitor in the preparation of antitumor drugs.
    Type: Application
    Filed: August 24, 2017
    Publication date: July 11, 2019
    Inventors: Fajun NAN, Jia LI, Jian DING, Meiyu GENG, Yangming ZHANG, Yi CHEN, Yubo ZHOU, Chaojun GONG, Mingbo SU, Anhui GAO
  • Patent number: 9643941
    Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2?-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2?-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 9, 2017
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun Nan, Jia Li, Xin Xie, Chaojun Gong, Yubo Zhou, Hui Chai, Yangming Zhang, Mingbo Su
  • Publication number: 20170044119
    Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2?-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2?-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.
    Type: Application
    Filed: March 27, 2015
    Publication date: February 16, 2017
    Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Fajun NAN, Jia LI, Xin XIE, Chaojun GONG, Yubo ZHOU, Hui CHAI, Yangming ZHANG, Mingbo SU