Abstract: Provided are tetrahydroisoquinoline derivatives, the preparation and use thereof. More specifically, provided are the tetrahydroisoquinoline derivatives or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, polymorph, solvate, isotopically labeled compound, metabolite or prodrug thereof. Further provided are a preparation process of the compound, the intermediates, a pharmaceutical composition comprising the compound and the use thereof in the treatment or prevention of a thromboembolic disorder.

Abstract: A repairing method for an array substrate is provided. The array substrate includes at least one defective signal line, which is a data line or a gate line having a breakpoint. The defective signal line is divided by the breakpoint into a first portion and a second portion. The repairing method includes disconnecting a connection between a first thin film transistor and a data line or a gate line to which the first thin film transistor is connected, the first thin film transistor being a thin film transistor closest to the breakpoint among thin film transistors connected to the first portion; electrically connecting a first terminal of the first thin film transistor to the first portion; and taking a common electrode line segment from a common electrode line to which the first pixel electrode corresponds as a repair line.

Abstract: Related is a nitrogen-containing benzoheterocycle compound containing a carboxylic acid group as shown in general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof. The compound has excellent pharmacokinetic properties and extremely remarkable liver targeting properties, and a pharmaceutical composition comprising the same may be used as a CCR antagonist, in particular a CCR2 and/or CCR5 antagonist and can be used in mediated disease, including, but not limited to, nonalcoholic fatty liver disease (NAFLD) or the like.

Abstract: A repairing method for an array substrate is provided. The array substrate includes at least one defective signal line, which is a data line or a gate line having a breakpoint. The defective signal line is divided by the breakpoint into a first portion and a second portion. The repairing method includes disconnecting a connection between a first thin film transistor and a data line or a gate line to which the first thin film transistor is connected, the first thin film transistor being a thin film transistor closest to the breakpoint among thin film transistors connected to the first portion; electrically connecting a first terminal of the first thin film transistor to the first portion; and taking a common electrode line segment from a common electrode line to which the first pixel electrode corresponds as a repair line.

Abstract: Provided are tetrahydroisoquinoline derivatives, the preparation and use thereof. More specifically, provided are the tetrahydroisoquinoline derivatives or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, polymorph, solvate, isotopically labeled compound, metabolite or prodrug thereof. Further provided are a preparation process of the compound, the intermediates, a pharmaceutical composition comprising the compound and the use thereof in the treatment or prevention of a thromboembolic disorder.

Abstract: The present disclosure provides an array substrate and a method for repairing the same, and a display panel. The array substrate includes gate lines extending in a first direction, and data lines and common electrode lines extending in a second direction. The gate lines intersect with the common electrode lines and the data lines to define pixel units. Every two adjacent pixel units at two sides of a common electrode line constitute a pixel unit group. Common electrodes of two pixel units in a pixel unit group are each connected to a common electrode line therebetween. The array substrate further includes a repairing structure including a first repairing line, a second repairing line at two sides of a data line, respectively, and a middle line intersecting with the data line and connecting a first point of the first repairing line and a second point of the second repairing line.

Abstract: Related is a nitrogen-containing benzoheterocycle compound containing a carboxylic acid group as shown in general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof. The compound has excellent pharmacokinetic properties and extremely remarkable liver targeting properties, and a pharmaceutical composition comprising the same may be used as a CCR antagonist, in particular a CCR2 and/or CCR5 antagonist and can be used in mediated disease, including, but not limited to, nonalcoholic fatty liver disease (NAFLD) or the like.

Abstract: The present disclosure provides an array substrate and a method for repairing the same, and a display panel. The array substrate includes gate lines extending in a first direction, and data lines and common electrode lines extending in a second direction. The gate lines intersect with the common electrode lines and the data lines to define pixel units. Every two adjacent pixel units at two sides of a common electrode line constitute a pixel unit group. Common electrodes of two pixel units in a pixel unit group are each connected to a common electrode line therebetween. The array substrate further includes a repairing structure including a first repairing line, a second repairing line at two sides of a data line, respectively, and a middle line intersecting with the data line and connecting a first point of the first repairing line and a second point of the second repairing line.

Abstract: The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection.

Abstract: The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection.