Abstract: A method for detecting a stress state-of rocks surrounding a roadway based on three-dimensional electric potential response is disclosed. By collecting electric potential data, and performing spatial interpolation on all the electric potential measurement points to obtain a three-dimensional electric potential imaging volume, three-dimensional electric potentials can be used to draw electric potential isosurface models. By using a radial basis function surface interpolation method to draw a three-dimensional abnormal electric potential inversion probability isosurface model, it is possible to intuitively visualize electric potential distribution spatial characteristics of rocks surrounding a roadway, so as to clearly display a spatial range, direction and development trend of abnormal stress zones, and accurately identify and determine the stress states of roadway rock formations.

Abstract: Disclosed herein is a computational algorithm that statistically infer a PPR code (preference of a PPR motif for a nucleotide base) while matching PPR proteins with their targets accurately without requiring experimental pairing information. From comprehensive lists of PLS-type PPR proteins and editing sites from more than 1500 PPRs, the algorithm derived a quantitative code including novel amino acid combinations in key positions that confer high specificity. For example, the predicted targets suggests that the recently identified DYW:KP domain is unequivocally responsible for the poorly characterized reverse U-to-C editing.

Abstract: Methods for generating mature neurons differentiated from pluripotent stem cells, such as to facilitate the study of late-onset neurodegenerative disease, are disclosed. The methods include overexpressing the splicing factor muscleblind like splicing regulator 2 (Mbnl2) in cortical neurons. In some aspects, the method further comprises overexpressing RNA binding fox-1 homolog 1 (Rbfox1) and/or reducing expression of polypyrimidine tract binding proteins PTBP1/2. The methods also include accelerated derivation of mature neuron and generation of a tau pathology model. Also disclosed are constructs and compositions for accelerated derivation of mature neuron and/or generation of a tau pathology model.

Abstract: The present disclosure provides a method for detecting stress state of roadway surrounding rocks based on three-dimensional electric potential response.

Abstract: A fluidized coal mining method utilizing self-energy storage of a coal seam is provided, and includes developing a mine roadway, uncovering coal actively, mining coal in fluidization, and backfilling a goaf. Dynamic phenomenon is induced by uncovering the coal actively, a coal-mining drilling well is established from a ground to the coal seam, and the coal seam is subjected to hydraulic in-situ cutting, and a coal-rock mixture subjected to hydraulic cutting flows into a roadway system along a floor roadway, and then coal, gangue and water in the mixture are separated and recycled in a subsequent circulating coal mining process.

Abstract: Compounds for, and methods of, modeling and treating a neurodegenerative disease, including without limitation frontal temporal dementia (FTD), are provided. An effective dose of a pharmaceutical composition is administered to a patient in need thereof, where the pharmaceutical composition targets at least one muscleblind-like protein (MBNL) binding site on exon 10 of microtubule-associated protein tau (MAPT) to block MBNL binding thereto. The at least one MBNL binding site may be 2 binding sites. The pharmaceutical composition may include the nuclease-inactive dCas13d in complex, with one or more guide RNAs, and/or antisense oligonucleotides (ASOs).

Abstract: A fluidized coal mining method utilizing self-energy storage of a coal seam is provided, and includes developing a mine roadway, uncovering coal actively, mining coal in fluidization, and backfilling a goaf. Dynamic phenomenon is induced by uncovering the coal actively, a coal-mining drilling well is established from a ground to the coal seam, and the coal seam is subjected to hydraulic in-situ cutting, and a coal-rock mixture subjected to hydraulic cutting flows into a roadway system along a floor roadway, and then coal, gangue and water in the mixture are separated and recycled in a subsequent circulating coal mining process.

Abstract: A method of increasing or decreasing expression of a target mRNA and protein for treatment of certain disease conditions by cells having a pre-mRNA that comprises a poison exon and encodes the target protein, and can include contacting the cells with an antisense oligomer (ASO) complementary to a targeted portion of the pre-mRNA.

Abstract: The present invention discloses a hydrogenation catalyst comprising metallic palladium supported on activated carbon support, wherein the penetration depth of metallic palladium in the support is at least about 10 ?m and up to about 100 ?m, the crystallite size of palladium is between about 40 ? and about 120 ?, and the palladium in the surface layer from the surface of support to a depth of 1 ?m is from about 5% to about 40% based on the total atom number of palladium and other elements. The present invention further discloses a process for preparing the hydrogenation catalyst, and a use of said hydrogenation catalyst in the purification of crude terephthalic acid.

Abstract: The present invention discloses a hydrogenation catalyst comprising metallic palladium supported on activated carbon support, wherein the penetration depth of metallic palladium in the support is at least about 10 ?m and up to about 100 ?m, the crystallite size of palladium is between about 40 ? and about 120 ?, and the palladium in the surface layer from the surface of support to a depth of 1 ?m is from about 5% to about 40% based on the total atom number of palladium and other elements. The present invention further discloses a process for preparing the hydrogenation catalyst, and a use of said hydrogenation catalyst in the purification of crude terephthalic acid.