Abstract: The present disclosure relates to a combined pharmaceutical composition containing a CDK4/6 inhibitor and a use thereof, and specifically relates to a combined pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and fulvestrant. The present disclosure further relates to a use of the combined pharmaceutical composition in treating breast cancer. The combined pharmaceutical composition of the present disclosure produces better therapeutic effects in reducing tumor growth or even eliminating tumors.

Abstract: The present application belongs to the field of medicinal chemistry, and relates to a use of a pyrido[1,2-a]pyrimidinone compound in treating lymphoma. Specifically, the present application relates to a pyrido[1,2-a]pyrimidinone compound or a pharmaceutical composition thereof for treating lymphoma, and a method or use of pyrido[1,2-a]pyrimidinone compound in treating lymphoma.

Abstract: The present invention belongs to the field of medicine, and provides a quinoline compound or a pharmaceutically acceptable salt thereof for treating Ewing's sarcoma, and particularly relates to use of compound I or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating Ewing's sarcoma and use of compound I or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent in the preparation of a combination medicament for treating Ewing's sarcoma. The chemical name of compound I is 1[[[4-(4-fluoro-2-methyl-1H-indo1-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropanamine.

Abstract: The present application relates to the field of biomedicine, and relates to a combined pharmaceutical composition for treating biliary tract tumor, liver cancer, triple negative breast cancer or lung cancer. The combined pharmaceutical composition comprises an anti-PD-L1 antibody and anlotinib, and has good anti-biliary tract tumor, liver cancer, triple negative breast cancer or lung cancer activity.