Abstract: Provided is a novel strain of Lactobacillus reuteri, which is preserved in the China Center for Type Culture Collection on 25 Jan. 2021 as Lactobacillus reuteri VHPribo E18 having a preservation number of CCTCC NO: M2021153. The provided Lactobacillus reuteri VHProbi E18 has strong tolerance for artificial intestine gastric fluids and can be germinated in the artificial intestine gastric fluids. The strain is sensitive to common antibiotics such as erythromycin and ampicillin, does not produce hemolysin, cannot dissolve blood cells, and has excellent biological safety. The provided Lactobacillus reuteri VHPribo E18 can be used for preparing functional food or cosmetics which have the effects of delaying and repairing skin aging, and has wide application prospects.

Abstract: Generating a control output for a patterning process is described. A control input is received. The control input is for controlling the patterning process. The control input includes one or more parameters used in the patterning process. The control output is generated with a trained machine learning mod& based on the control input, The machine learning model is trained with training data generated from simulation of the patterning process and/or actual process data, The training data includes 1) a plurality of training control inputs corresponding to a plurality of operational conditions of the patterning process, where the plurality of operational conditions of the patterning process are associated with operational condition specific behavior of the patterning process over time, and 2) training control outputs generated using a physical model based on the training control inputs.