Patents by Inventor Chaoshe Guo

Chaoshe Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CCR8
    Publication number: 20230320332
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CCR8, and methods of use thereof.
    Type: Application
    Filed: September 10, 2021
    Publication date: October 12, 2023
    Inventors: Yuelei SHEN, Yang BAI, Chaoshe GUO, Meiling ZHANG, Rui HUANG, Chengzhang SHANG
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD94 AND/OR NKG2A
    Publication number: 20230172171
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD94 and/or NKG2A, and methods of use thereof.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 8, 2023
    Inventors: Yuelei Shen, Yang Bai, Chaoshe Guo, Meiling Zhang, Rui Huang, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL1B AND/OR IL1A
    Publication number: 20230148575
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL1B and/or IL1A, and methods of use thereof.
    Type: Application
    Filed: April 7, 2021
    Publication date: May 18, 2023
    Inventors: Yuelei Shen, Meiling Zhang, Rui Huang, Yang Bai, Chaoshe Guo, Xiaofei Zhou
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC MHC PROTEIN COMPLEX
    Publication number: 20230072216
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) major histocompatibility complex (MHC) protein complex, and methods of use thereof.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 9, 2023
    Inventors: Yuelei Shen, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Yang Bai, Jiawei Yao, Chengzhang Shang
  • GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPa/CD47
    Publication number: 20230058049
    Abstract: This disclosure relates to genetically modified immunodeficient animals which express a human or chimeric (e.g., humanized) SIRP? and/or human or chimeric (e.g., humanized) CD47, and methods of use thereof.
    Type: Application
    Filed: December 31, 2020
    Publication date: February 23, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Chengzhang Shang
  • HUMANIZED TRANSGENIC ANIMAL
    Publication number: 20230043907
    Abstract: Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.
    Type: Application
    Filed: August 1, 2022
    Publication date: February 9, 2023
    Inventors: Yuelei Shen, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Xiaofei Zhou, Meiling Zhang, Jiawei Yao
  • Genetically modified non-human animal with human or chimeric LAG3
    Patent number: 11564381
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) LAG3, and methods of use thereof.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: January 31, 2023
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Meiling Zhang
  • GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMAN OR CHIMERIC THPO
    Publication number: 20220408704
    Abstract: The present disclosure relates to genetically modified non-human animals expressing human or chimeric (e.g., humanized) Thrombopoietin (THPO), and methods of use thereof.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 29, 2022
    Inventors: Yuelei Shen, Rui Huang, Yanan Guo, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
    Publication number: 20220378025
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL10R and/or a human or chimeric (e.g., humanized) IL10, and methods of use thereof.
    Type: Application
    Filed: November 11, 2020
    Publication date: December 1, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang, Rui Huang, Lei Zhao, Xiaofei Zhou
  • Genetically modified non-human animal with human or chimeric OX40
    Patent number: 11505806
    Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 22, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Yang Bai, Jiawei Yao, Meiling Zhang, Xiaofei Zhou
  • Genetically modified mice expressing humanized CD40
    Patent number: 11497198
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD40, and methods of use thereof.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: November 15, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Rui Huang, Lei Zhao, Yanan Guo, Yang Bai, Meiling Zhang, Jiawei Yao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC TNFR2
    Publication number: 20220346357
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) TNFR2, and methods of use thereof.
    Type: Application
    Filed: September 4, 2020
    Publication date: November 3, 2022
    Inventors: Yuelei Shen, Rui Huang, Yanan Guo, Yang Bai, Lei Zhao, Jiawei Yao, Chaoshe Guo, Meiling Zhang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL2RA
    Publication number: 20220312749
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL2RA, and methods of use thereof.
    Type: Application
    Filed: August 7, 2020
    Publication date: October 6, 2022
    Inventors: Yuelei Shen, Yang Bai, Chengzhang Shang, Rui Huang, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo
  • Humanized transgenic animal
    Patent number: 11439132
    Abstract: Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: September 13, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Xiaofei Zhou, Meiling Zhang, Jiawei Yao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL33
    Publication number: 20220272953
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL33, and methods of use thereof.
    Type: Application
    Filed: July 29, 2020
    Publication date: September 1, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Chengzhang Shang, Rui Huang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD73
    Publication number: 20220211019
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD73, and methods of use thereof.
    Type: Application
    Filed: November 20, 2019
    Publication date: July 7, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • Genetically modified non-human animal with human or chimeric PD-L1
    Patent number: 11317611
    Abstract: Non-human animals, methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanized programmed death-ligand 1 (PD-L1, PDL1, or B7-H1). Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous PD-L1 gene so that the non-human animals express a humanized PD-L1 protein that includes a human portion and an endogenous portion (e.g., a non-human portion).
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: May 3, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yang Bai, Yanan Guo, Rui Huang, Xiaofei Zhou, Chaoshe Guo
  • Genetically modified non-human animal with human or chimeric OX40
    Patent number: 11279948
    Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: March 22, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Yang Bai, Jiawei Yao, Meiling Zhang, Xiaofei Zhou
  • Genetically modified non-human animal with human or chimeric PD-1
    Patent number: 11272695
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: March 15, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Xiaofei Zhou, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • Genetically modified non-human animal with human or chimeric IL15
    Patent number: 11234421
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL15, and methods of use thereof.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: February 1, 2022
    Assignees: Biocytogen JiangSu Co., Ltd., Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao