Patents by Inventor Chaoyang Xue

Chaoyang Xue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal peptides, compounds including the same, and methods of use thereof
    Patent number: 11939402
    Abstract: An antifungal peptide targeting P4-ATPase function is synthesized based on Cdc50 loop region to identify peptides sensitize caspofungin by blocking flippase function. It was found that myristylated peptides based on “AS15 sequence” was effective at high concentrations. A modified peptide, “AW9-Ma” showed minimum inhibitory concentration (MIC) of 64 ?g/mL against H99 wild type and fractional inhibitory concentration (FIC) index value of 0.5 when used with caspofungin. With the AW9-Ma peptide, C. neoformans wild type was highly sensitive to caspofungin with a MIC of 4 ?g/mL, the same as cdc50? mutant. Further assays with flow cytometry showed inhibition of lipid flippase enzyme activity and significant accumulation of phosphatidylserine on the cell surface. It was confirmed that the peptide co-localized with mCherry-tagged P4-ATPase protein Apt1 in C. neoformans.
    Type: Grant
    Filed: March 29, 2023
    Date of Patent: March 26, 2024
    Assignees: Seton Hall University, Rutgers, The State University of New Jersey
    Inventors: Gregory R. Wiedman, Robert J. Tancer, Chaoyang Xue
  • Antifungal Peptides, Compounds Including The Same, And Methods Of Use Thereof
    Publication number: 20230312650
    Abstract: An antifungal peptide targeting P4-ATPase function is synthesized based on Cdc50 loop region to identify peptides sensitize caspofungin by blocking flippase function. It was found that myristylated peptides based on “AS15 sequence” was effective at high concentrations. A modified peptide, “AW9-Ma” showed minimum inhibitory concentration (MIC) of 64 ?g/mL against H99 wild type and fractional inhibitory concentration (FIC) index value of 0.5 when used with caspofungin. With the AW9-Ma peptide, C. neoformans wild type was highly sensitive to caspofungin with a MIC of 4 ?g/mL, the same as cdc50? mutant. Further assays with flow cytometry showed inhibition of lipid flippase enzyme activity and significant accumulation of phosphatidylserine on the cell surface. It was confirmed that the peptide co-localized with mCherry-tagged P4-ATPase protein Apt1 in C. neoformans.
    Type: Application
    Filed: March 29, 2023
    Publication date: October 5, 2023
    Applicants: Seton Hall University, Rutgers, The State University of New Jersey
    Inventors: Gregory R. Wiedman, Robert J. Tancer, Chaoyang Xue
  • METHODS OF TREATING FUNGAL INFECTIONS
    Publication number: 20210330768
    Abstract: This invention describes vaccine compositions and their methods of use utilizing inactivated fbp1? deletion mutant fungal cells.
    Type: Application
    Filed: April 7, 2021
    Publication date: October 28, 2021
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Chaoyang Xue, Amariliz Rivera
  • Fungal vaccine compositions and methods of use thereof
    Patent number: 10987422
    Abstract: This invention describes vaccine compositions and their methods of use utilizing inactivated fbp1? deletion mutant fungal cells.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: April 27, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Chaoyang Xue, Amariliz Rivera
  • FUNGAL VACCINE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20190290760
    Abstract: This invention describes vaccine compositions and their methods of use utilizing inactivated fbp1? deletion mutant fungal cells.
    Type: Application
    Filed: July 11, 2017
    Publication date: September 26, 2019
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Chaoyang Xue, Amariliz Rivera