Patents by Inventor CHARAN DEVARAKONDA

CHARAN DEVARAKONDA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarker panel for non-invasive diagnosis of congenital renal dysfunction
    Patent number: 11940450
    Abstract: Disclosed herein are methods and compositions for prognosing or diagnosing an obstructive renal dysfunction or ureteropelvic junction obstruction (UPJO) in a subject, involving detecting in a urine sample from a subject one or more proteins selected from the group consisting of Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR); Nicotinate-nucleotide pyrophosphorylase [carboxylating] (QPRT); Prostaglandin reductase 1 (PTGR1); Vascular cell adhesion protein 1 (VCAM1); and Ficolin-2 (FCN2), or detectable portions thereof to identify the subject as at risk of or having an obstructive renal dysfunction or UPJO.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: March 26, 2024
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Linda H. Shapiro, Fernando A. Ferrer, Charan Devarakonda, James J. Grady
  • Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof
    Patent number: 11459381
    Abstract: Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY (SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: October 4, 2022
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Kevin P. Claffey, Charan Devarakonda, Daniel Kita
  • Biomarker Panel for Non-Invasive Diagnosis of Congenital Renal Dysfunction
    Publication number: 20220299530
    Abstract: Disclosed herein are methods and compositions for prognosing or diagnosing an obstructive renal dysfunction or ureteropelvic junction obstruction (UPJO) in a subject, involving detecting in a urine sample from a subject one or more proteins selected from the group consisting of Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR); Nicotinate-nucleotide pyrophosphorylase [carboxylating] (QPRT); Prostaglandin reductase 1 (PTGR1); Vascular cell adhesion protein 1 (VCAM1); and Ficolin-2 (FCN2), or detectable portions thereof to identify the subject as at risk of or having an obstructive renal dysfunction or UPJO.
    Type: Application
    Filed: March 15, 2022
    Publication date: September 22, 2022
    Inventors: Linda H. SHAPIRO, Fernando A. FERRER, Charan DEVARAKONDA, James J. GRADY
  • ANTIBODY AND ANTIGEN-BINDING FRAGMENT COMPOSITIONS TARGETING CELL SURFACE ANTIGENS IN TUMORS AND METHODS OF USE THEREOF
    Publication number: 20190375830
    Abstract: Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY (SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.
    Type: Application
    Filed: August 7, 2019
    Publication date: December 12, 2019
    Inventors: KEVIN P. CLAFFEY, CHARAN DEVARAKONDA, DANIEL KITA
  • Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof
    Patent number: 10457726
    Abstract: Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY(SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Kevin P. Claffey, Charan Devarakonda, Daniel Kita
  • ANTIBODY AND ANTIGEN-BINDING FRAGMENT COMPOSITIONS TARGETING CELL SURFACE ANTIGENS IN TUMORS AND METHODS OF USE THEREOF
    Publication number: 20180002412
    Abstract: Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY(SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.
    Type: Application
    Filed: June 29, 2017
    Publication date: January 4, 2018
    Inventors: KEVIN P. CLAFFEY, CHARAN DEVARAKONDA, DANIEL KITA