Patents by Inventor Charbel Massaad

Charbel Massaad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense RNA targeting PMP22 for the treatment of Charcot-Marie-Tooth 1A disease
    Patent number: 11939577
    Abstract: The present invention relates to antisense RNAs targeting PMP22 and able to inhibit from 40% to 60% the expression of PMP22 in the cells and a pharmaceutical composition comprising thereof. The antisense RNAs are preferably siRNA and are preferably provided in the form of nanoparticles. The present invention also relates to the use of these antisense RNAs targeting PMP22 for the treatment of Charcot-Marie-Tooth 1A disease.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: March 26, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Liliane Massade, Charbel Massaad, Susan Boutary, Giorgia Maria Laura Urbinati, Patrick Couvreur, Didier Desmaële
  • ANTISENSE RNA TARGETING PMP22 FOR THE TREATMENT OF CHARCOT-MARIE-TOOTH 1A DISEASE
    Publication number: 20220002721
    Abstract: The present invention relates to antisense RNAs targeting PMP22 and able to inhibit from 40% to 60% the expression of PMP22 in the cells and a pharmaceutical composition comprising thereof. The antisense RNAs are preferably siRNA and are preferably provided in the form of nanoparticles. The present invention also relates to the use of these antisense RNAs targeting PMP22 for the treatment of Charcot-Marie-Tooth 1A disease.
    Type: Application
    Filed: September 24, 2019
    Publication date: January 6, 2022
    Inventors: Liliane MASSADE, Charbel MASSAAD, Susan BOUTARY, Giorgia Maria Laura URBINATI, Patrick COUVREUR, Didier DESMAËLE
  • Inflammation inducible hybrid promoters, vectors comprising them and uses thereof
    Patent number: 6870044
    Abstract: The present invention relates to the field of the regulation of the expression of genes and is based in particular on the use of constructs which make it possible to activate the transcription of a transgene in cells, tissues or organs under inflammatory conditions. The promoters of the invention preferably comprise a) a PPAR response element and b) the whole or part of the promoter of the PLA2sIIA gene. The invention also relates to vectors, cells and compositions comprising these promoters, as well as their use for the regulation of the expression of genes in vitro, ex vivo or in vivo.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: March 22, 2005
    Assignee: Universite Pierre et Marie Curie
    Inventors: Charbel Massaad, Francis Berenbaum, Jean-Luc Olivier, Colette Salvat, Gilbert Bereziat
  • Inflammation inducible hybrid promoters, vectors comprising them and uses thereof
    Publication number: 20020081719
    Abstract: The present invention relates to the field of the regulation of the expression of genes and is based in particular on the use of constructs which make it possible to activate the transcription of a transgene in cells, tissues or organs under inflammatory conditions. The promoters of the invention preferably comprise a) a PPAR response element and b) the whole or part of the promoter of the PLA2sIIA gene. The invention also relates to vectors, cells and compositions comprising these promoters, as well as their use for the regulation of the expression of genes in vitro, ex vivo or in vivo.
    Type: Application
    Filed: March 14, 2001
    Publication date: June 27, 2002
    Inventors: Charbel Massaad, Francis Berenbaum, Jean-Luc Olivier, Colette Salvat, Gilbert Bereziat