Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract: Methods and systems for monitoring an ongoing procedure are described. In an example, a processor can receive a first set of data indicating a current context of a procedure being performed by a first entity on a second entity. The processor can determine a first score based on the first set of data, where the first score can indicate an effectiveness of the procedure. The processor can identify a set of requirements based on the first score. The set of requirements can be associated with a second score indicating a target effectiveness of the procedure. The processor can generate a recommendation for the first entity to perform the set of requirements to achieve the second score.

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract: A method of managing lifelong learner events on a blockchain includes detecting an event related to a learner using a blockchain-enabled digital learning system, determining a concern/risk level of the learner by performing a risk assessment, determining parameters to generate a transaction related the learner's event based on the parameters and the concern/risk level, determining the values of the parameters by measuring the value or importance of the event and its associated metadata and documents, generating a list of transactions corresponding to the parameters, and validating the transactions using validating distributed peer-to-peer devices that run one or more chaincodes related to the management of the lifelong learner events.

Abstract: An estimate is made of a time since a given presenting cancer would have first been detectable using a known diagnostic technique, and an estimate is also made of initial characteristics of the given presenting cancer at the time when it would have first been detectable using the known diagnostic technique. A first probability of the cancer being present in a first set of one or more clinically significant remote sites is determined based on the estimated initial characteristics. A second probability of the cancer being present in the first set of one or more clinically significant remote sites is determined based on actual current characteristics of the given presenting cancer. The first and second probabilities are used to estimate incremental risk of incurring presence of the cancer at the first set of one or more clinically significant remote sites by delaying therapy for a unit time.

Abstract: The disclosure provides systems and methods for maintaining integrity of documents and activities associated with examinations. The systems and methods store such activities and documents in a distributed blockchain such that integrity is maintained through transparency and redundancy of the records and activities. The systems monitor for any anomalies and notify appropriate individuals when an anomaly is detected, as well as maintaining a log of such anomalies.

Abstract: An estimate is made of a time since a given presenting cancer would have first been detectable using a known diagnostic technique, and an estimate is also made of initial characteristics of the given presenting cancer at the time when it would have first been detectable using the known diagnostic technique. A first probability of the cancer being present in a first set of one or more clinically significant remote sites is determined based on the estimated initial characteristics. A second probability of the cancer being present in the first set of one or more clinically significant remote sites is determined based on actual current characteristics of the given presenting cancer. The first and second probabilities are used to estimate incremental risk of incurring presence of the cancer at the first set of one or more clinically significant remote sites by delaying therapy for a unit time.

Abstract: The disclosure provides systems and methods for maintaining integrity of documents and activities associated with examinations. The systems and methods store such activities and documents in a distributed blockchain such that integrity is maintained through transparency and redundancy of the records and activities. The systems monitor for any anomalies and notify appropriate individuals when an anomaly is detected, as well as maintaining a log of such anomalies.

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract: The disclosure provides systems and methods for maintaining integrity of documents and activities associated with examinations. The systems and methods store such activities and documents in a distributed blockchain such that integrity is maintained through transparency and redundancy of the records and activities. The systems monitor for any anomalies and notify appropriate individuals when an anomaly is detected, as well as maintaining a log of such anomalies.

Abstract: The disclosure provides systems and methods for maintaining integrity of documents and activities associated with examinations. The systems and methods store such activities and documents in a distributed blockchain such that integrity is maintained through transparency and redundancy of the records and activities. The systems monitor for any anomalies and notify appropriate individuals when an anomaly is detected, as well as maintaining a log of such anomalies.

Abstract: A method of managing lifelong learner events on a blockchain includes detecting an event related to a learner using a blockchain-enabled digital learning system, determining a concern/risk level of the learner by performing a risk assessment, determining parameters to generate a transaction related the learner's event based on the parameters and the concern/risk level, determining the values of the parameters by measuring the value or importance of the event and its associated metadata and documents, generating a list of transactions corresponding to the parameters, and validating the transactions using validating distributed peer-to-peer devices that run one or more chaincodes related to the management of the lifelong learner events.

Abstract: A method of managing a school system using a blockchain includes receiving a transaction related to a school record along with chaincodes to validate the transaction and a set of record tokens that represent events with respect to a stakeholder, obtaining a historical block identifier from a blockchain of historical school records that is representative of historical record events in the blockchain, receiving validity requirements for the events on the record, obtaining a validation token that is indicative of a validity of the events based on the set of record tokens, computing a chaincode block for the transaction against the one or more validation requirements as a function of the validation token, the historical school record's block identifier, and the set of record tokens, and creating a new block and upadating the blockchain of historical school records based on the new block the transaction, when the validation succeeds,

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract: An estimate is made of a time since a given presenting cancer would have first been detectable using a known diagnostic technique, and an estimate is also made of initial characteristics of the given presenting cancer at the time when it would have first been detectable using the known diagnostic technique. A first probability of the cancer being present in a first set of one or more clinically significant remote sites is determined based on the estimated initial characteristics. A second probability of the cancer being present in the first set of one or more clinically significant remote sites is determined based on actual current characteristics of the given presenting cancer.

Abstract: An estimate is made of a time since a given presenting cancer would have first been detectable using a known diagnostic technique, and an estimate is also made of initial characteristics of the given presenting cancer at the time when it would have first been detectable using the known diagnostic technique. A first probability of the cancer being present in a first set of one or more clinically significant remote sites is determined based on the estimated initial characteristics. A second probability of the cancer being present in the first set of one or more clinically significant remote sites is determined based on actual current characteristics of the given presenting cancer.

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.