Abstract: This disclosure provides a novel method of controlling the glycosylation profile of a protein during production. The disclosure also provides a novel method of improving protein yield while controlling the glycosylation profile of a protein.

Abstract: An accessory device with a cover and keyboard section is described. The keyboard section includes a keyboard and a touchpad, while the cover section includes multiple segments. The cover section orients the electronic device such that a user can access the electronic device, the keyboard, and the touchpad. The cover section is rotationally coupled to the keyboard section by one or more hinge assemblies (including clutches and springs), allowing the cover section and the electronic device to rotate relative to the keyboard section. The cover section includes a first and second segment rotationally coupled together. To further adjust the electronic device, the first segment remains coupled to the electronic device, allowing the first segment and the electronic device to rotate relative to the second segment. The cover section can then suspend the electronic device over the keyboard section, and the electronic device does not contact the keyboard section.

Abstract: An accessory device with a cover and keyboard section is described. The keyboard section includes a keyboard and a touchpad, while the cover section includes multiple segments. The cover section orients the electronic device such that a user can access the electronic device, the keyboard, and the touchpad. The cover section is rotationally coupled to the keyboard section by one or more hinge assemblies (including clutches and springs), allowing the cover section and the electronic device to rotate relative to the keyboard section. The cover section includes a first and second segment rotationally coupled together. To further adjust the electronic device, the first segment remains coupled to the electronic device, allowing the first segment and the electronic device to rotate relative to the second segment. The cover section can then suspend the electronic device over the keyboard section, and the electronic device does not contact the keyboard section.

Abstract: The disclosure provides a method of separating a protein product, e.g., from a contaminant in a mixture, comprising contacting the mixture with a polishing chromatography matrix. In some embodiments, the polishing chromatography matrix is used together with a retained gradient. In certain embodiments, the retained gradient comprises a pH gradient. In certain embodiments, the mixture comprises a monoclonal antibody product of a prior protein A chromatography.

Abstract: An accessory device with a cover and keyboard section is described. The keyboard section includes a keyboard and a touchpad, while the cover section includes multiple segments. The cover section orients the electronic device such that a user can access the electronic device, the keyboard, and the touchpad. The cover section is rotationally coupled to the keyboard section by one or more hinge assemblies (including clutches and springs), allowing the cover section and the electronic device to rotate relative to the keyboard section. The cover section includes a first and second segment rotationally coupled together. To further adjust the electronic device, the first segment remains coupled to the electronic device, allowing the first segment and the electronic device to rotate relative to the second segment. The cover section can then suspend the electronic device over the keyboard section, and the electronic device does not contact the keyboard section.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: An accessory device for an electronic device is described. The accessory device may include a cover section and a keyboard section. The cover section may include a receiving surface that engages the electronic device. The cover section may include electrical contacts designed to electrically couple with contacts on the electronic device. The cover section may include several magnets designed to magnetically couple with magnets within the electronic device. The keyboard section may include a keyboard and one or more channels designed to receive and position the electronic device in a usable configuration with the keyboard. Several magnets may surround each channel, and may magnetically couple with magnets within (and along an edge of) the electronic device. The magnetic circuits formed between the channel magnets and the device magnets may counter, or offset, forces that otherwise remove the electronic device from the channel in an undesired manner.

Abstract: An accessory device for an electronic device is described. The accessory device may include a cover section and a keyboard section. The cover section may include a receiving surface that engages the electronic device. The cover section may include electrical contacts designed to electrically couple with contacts on the electronic device. The cover section may include several magnets designed to magnetically couple with magnets within the electronic device. The keyboard section may include a keyboard and one or more channels designed to receive and position the electronic device in a usable configuration with the keyboard. Several magnets may surround each channel, and may magnetically couple with magnets within (and along an edge of) the electronic device. The magnetic circuits formed between the channel magnets and the device magnets may counter, or offset, forces that otherwise remove the electronic device from the channel in an undesired manner.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

Abstract: A wall-plate system is disclosed. The wall-plate system may include a face plate, a back plate, electronic circuitry comprising an electrical port, a clip, and a conductor. The face plate may have a front, a back, and at least one outlet aperture. The back plate may abut the back of the face plate and have a wall extending rearward away from the face plate. The clip may connect to the face plate and extend rearward away from the back of the face plate. The clip may be positioned laterally inboard of the wall and resiliently deflect from a neutral position spaced from the wall to a deflected position in contact with the wall. The conductor may be sandwiched between the face plate and the back plate and extend to electrically connect the clip to the electronic circuitry.

Abstract: An active cover plate is disclosed. The active cover plate may include a face plate, a back plate; an electrical load, at least one clip may extend rearward from the face plate and a wall may extend rearward from the back plate, where the wall may cover at least a part of a rear of the clip, and an electrical connection may connect the electrical load to the clip.

Abstract: An active cover plate is disclosed. The active cover plate may include a face plate, a back plate; an electrical load, at least one clip may extend rearward from the face plate and a wall may extend rearward from the back plate, where the wall may cover at least a part of a rear of the clip, and an electrical connection may connect the electrical load to the clip.