Abstract: The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).

Abstract: A plasma jet system includes a housing with a single opening. A plasma generator is coupled to ionize a fluid in the housing. An electromagnetic accelerator is coupled to generate an electric field that accelerates ionized fluid in the housing toward the opening. A controller can modulate the frequency of the electric field to cause the ionized fluid to form a plasma vortex flow through the opening. A magnetic field is applied normal to the direction of the plasma vortex flow to mitigate the momentum of the electrons. The electrons slowed by the magnetic field can be collected and conducted to a location where they are re-inserted into the plasma vortex flow to maintain charge neutrality.

Abstract: A surveillance system is provided for surveillance of objects within a secure area. A surveillance sensor transmits surveillance signals to all objects within the secure area, the reflections of which are received back by the surveillance sensor to determine the locations of objects, and communicates the determined locations to a pressing facility. Objects authorized to be in the secure area are equipped with an Identification Friend or Foe (IFF) unit that includes a GPS receiver and a data communication transmitter. In response to predetermined conditions, the IFF units broadcast their position and identification to the processing facility for correlation with locations defined by the reflection signals.

Abstract: The microstructure non-thermal visible light source may emit visible light. A microstructure element may be filled with a gas and may be disposed in a light transparent dielectric binder positioned between two spaced apart electrical conductors. An electrical source may be in electrical communication with the electrical conductors for the electrical source to transmit a signal to the electrical conductors to excite the gas to cause an electron in a plurality of gas molecules to transition to higher energy states. The higher energy states may be metastable and the higher energy states may decay with the emission of a photon at selected wavelengths.

Abstract: A tissue guidance system integrates an ultrasound imaging device with a tissue diagnostic probe. Ultrasound imaging is used to guide the tissue probe to the target area. Measurements made by the probe can then be analyzed to determine tissue type or state (e.g., malignant or benign).

Abstract: The invention relates to crystalline 1H-Imidazo[4,5-b]pyridin-5-amine, 7-[5-[(cyclohexylmethylamino)-methyl]-1H-indol-2-yl]-2-methyl, sulfate (1:1), trihydrate, E6070, its method of preparation, and its therapeutic uses. Pharmaceutical compositions containing crystalline E6070 and a pharmaceutically acceptable carrier represent one embodiment of the invention. The invention also relates to methods for treating an inflammatory disorder, an autoimmune disorder, or a proliferative disorder comprising the step of administering to a patient in need thereof a therapeutically effective amount of crystalline E6070.

Abstract: A plasma jet system includes a housing with an opening. A plasma generator is coupled to ionize a fluid in the housing. An electromagnetic accelerator is coupled to generate an electric field that accelerates ionized fluid in the housing toward the opening. A controller can modulate the frequency of the electric field to cause the ionized fluid to form a plasma vortex flow through the opening. A magnetic field is applied normal to the direction of the plasma vortex flow to mitigate the momentum of the electrons. The electrons slowed by the magnetic field can be collected and conducted to a location where they are re-inserted into the plasma vortex flow to maintain charge neutrality.

Abstract: A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A retractable sheath may be disposed around the distal section of the needle to protect the needle when not in use. The sheath retracts when the probe is inserted into tissue and the position of the sheath relative to the needle may be measured to determine the needle's depth. Systems and methods for tissue identification are also provided.

Abstract: A surveillance system is provided for surveillance of objects within a secure area. A surveillance sensor transmits surveillance signals to all objects within the secure area, the reflections of which are received back by the surveillance sensor to determine the locations of objects, and communicates the determined locations to a pressing facility. Objects authorized to be in the secure area are equipped with an Identification Friend or Foe (IFF) unit that includes a GPS receiver and a data communication transmitter. In response to predetermined conditions, the IFF units broadcast their position and identification to the processing facility for correlation with locations defined by the reflection signals.

Abstract: A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A retractable sheath may be disposed around the distal section of the needle to protect the needle when not in use. The sheath retracts when the probe is inserted into tissue and the position of the sheath relative to the needle may be measured to determine the needle's depth. Systems and methods for tissue identification are also provided.

Abstract: A unitary lampholder (10) including a lamp socket (12,14) as well as a multi-position switch which can take the form of a three-way, two circuit switch for operating a two filament lamp, a single circuit switch for operating a single filament lamp or arranged to permit the switch to be operated from a remote point. The lampholder has a bottom housing (14) and a top housing (12) which includes an access door (16) which is slidably and rotatably mounted to the remainder of the top housing by a guide member (54) which moves within slots (93,94) and permits the access door (16) to be rotated from a position on and perpendicular to the top housing axis to one parallel to that axis in which position it can be slidably moved towards the bottom housing. Upon slidably moving the access door towards the bottom housing, projections (160,162) on the base of access door force insulated conductors (92,94) into the insulation displacing terminals (86,88) of the contacts (60,62) to make electrical contact therewith.

Abstract: A lighting fixture composed of a lampholder which can receive an electrical lamp and supply to it AC power and a body member into which the lampholder can be placed for support and protection. A locking member in the form of a flat, resilient metallic band with end portions bent at an acute angle provides a one-way clutch which permits the lampholder to be placed into the body member but prevents its withdrawal. Channels in the interior wall of the body receive the band ends to prevent rotation of the lampholder. The channels are employed in pairs and a single pair or two pairs at right angles to each other are employed.

Abstract: A novel concrete block having six generally planar faces to provide a retaining wall for retaining a bank of earth. The retaining wall includes a lower tier of a plurality of separate abutting bottom blocks; an intermediate tier of a plurality of separate abutting intermediate blocks; and at least one upper tier of a plurality of separate abutting blocks. Each concrete block of each tier has six generally-planar faces, consisting of two planar end faces, a front planar face and a rear planar face, the front planar face and the rear planar face having a plurality of drainage ducts extending therebetween, an upper planar face and a lower planar face. Each upper planar face differs from the lower planar face of each block by a particular recited structure. As well, particularly defined locking interrelationships are provided between the individual blocks of the tiers of blocks.

Abstract: A unitary lampholder (10) including a lamp socket (12,14) as well as a multi-position switch which can take the form of a three-way, two circuit switch for operating a two filament lamp, a single circuit switch for operating a single filament lamp or arranged to permit the switch to be operated from a remote point. The lampholder has a bottom housing (14) and a top housing (12) which includes an access door (16) which is slidably and rotatably mounted to the remainder of the top housing by a guide member 54 which moves within slots (93,95) and permits the access door 16 to be rotated from a position on and perpendicular to the top housing axis to one parallel to that axis in which position it can be slidably moved towards the bottom housing, projections (160,162) on the base of access door force insulated conductors (92,94) into the insulation displacing terminals (86,88) of the contacts (60,62) to make electrical contact therewith.

Abstract: The present invention is for a means to relieve stress in slotted solid propellant rocket motors. The invention provides for one or more articulated members located between the outer edge of a secondary slot and the layer of thermal insulation. Also disclosed is a method of forming the articulated members.

Abstract: The present invention teaches a lockable lampholder mounting system wherein a housing containing electrical contacts, such as an electrical wiring device of the type exemplified by an incandescent lampholder or socket, is removably mounted upon a preselected panel by means of a novel clip arrangement. The panel is of the type utilized in a fixture, for example. The clip arrangement includes a resilient clip of predetermined shape formed with at least three bearing surfaces for contacting the panel, and preferably a fourth bearing surface against which a locking tab is biased to prevent rotation and relatively upward movement of the wiring device.

Abstract: Improved method for the pick up and delivery of a liquid test sample and diluent therefore by a single syringe having a syringe valve for placing the syringe barrel in fluid connection with either a diluent pick up line or a sample pick-up line. The method is comprised essentially of the steps of priming the apparatus, picking up the diluent through the diluent pick-up line and thereafter with a continuing downward stroke of the syringe plunger picking up a percentage volume of liquid sample. Preferably, an air bubble is picked up in the end of the sample pick-up line before the sample pick-up cycle. After the full downward stroke of the syringe plunger, the diluted sample is delivered by depressing the plunger to its zero volume setting.An apparatus is provided having a computer controlled syringe plunger drive which includes a zero volume switch, and a computer controlled syringe valve having branch ports adapted to be connected to a diluent and a sample pick-up line.