Abstract: A wand override tool adapted to couple with a hose of an extraction cleaner including a suction source includes a housing defining a first end and a second end. The first end connects with the hose and the second end connects with a wand. A cleaning solution reservoir is carried by the housing. A fluid delivery conduit can be disposed at the second end fluidly coupling the wand override tool and the wand when the wand is fully inserted within the housing of the wand override tool.

Abstract: A pet bathing system for use with a surface cleaning apparatus is provided and includes at least a wand override tool to allow for an easy-to-use pet bathing system. The system can be used for the bathing of pets via the application and subsequent extraction of liquid. The wand override tool includes a cleaning solution reservoir and couplers adapted to be coupled with a surface cleaning apparatus having a suction source and a cleaning fluid source and with a hand tool.

Abstract: Provided herein are oncolytic viruses including payload genes, encompassing genes that encode IL-12, FLT3L, CD40 agonists, and/or CTLA-4 antibodies. Also provided are expression cassettes, pharmaceutical compositions, and methods of treatment employing these viruses. Furthermore, expression cassettes and CD40 agonist molecules are also provided in this disclosure.

Abstract: Distributed ledger cores are disclosed.

Abstract: A method for generating postings may include a posting generation service (PGS) computer application executed by an electronic device: (1) receiving an instruction from a source system that requires generation and/or processing of account movements; (2) identifying a transaction type for the instruction; (3) retrieving a profile out of a plurality of profiles based on the transaction type, wherein the profile specifies one or more checks to be performed on the instruction; (4) retrieving rules associated with the profile; (5) generating postings for the transaction based the rules; (6) executing, by the PGS computer application, the one or more checks specified by the retrieved profile comprising a sanctions screening check, a fraud check, a fund check, a posting check, and an outgoing financial message check; and (7) generating an acknowledgement for the source system.

Abstract: A method may include: receiving, at a computer program in a distributed data processing system, a subscription request from a subscriber to receive processed data from the distributed data processing system comprising a plurality of nodes; receiving, by a receiving node of the plurality of nodes, information about data to be processed from one or more data source; determining, by the receiving node, a number of worker nodes needed to process the data based on the information about the data; breaking, by the receiving node, the data into plurality of data chunks based on the number of worker nodes; distributing, by the receiving node, the data chunks to the worker nodes; processing, by the worker nodes, the data chunks; receiving, by a gathering node of the plurality of nodes, the processed data; and distributing, by the gathering node, the processed data to the subscriber.

Abstract: Distributed ledger cores are disclosed.

Abstract: A method for structure management may include a structure management computer program: (1) establishing a structure for a plurality of elements within an organization, each element associated with a summary account, wherein the structure identifies a hierarchical relationship among the plurality of summary accounts and a plurality of activity accounts; (2) receiving, from a user interface for a user, a query comprising a query element; (3) identifying one of the plurality of summary accounts in the structure that matches the query element; (4) retrieving an identification of a subset of the activity accounts that are associated with the identified summary account from the structure; (5) querying a distributed ledger for activity account data for the subset of the activity accounts; and (6) returning the activity account data to the user interface.

Abstract: Distributed ledger cores are disclosed.

Abstract: A method for transaction processing using a ledger interoperability service in a blockchain-based distributed ledger system may include a ledger interoperability service: receiving a pending transaction request for a transaction from a distributed banking ledger; validating the pending transaction request; enriching the validated pending transaction; sending the enriched and validated pending transaction to a posting generation service, wherein the posting generation service creates a posting for the enriched and validated pending transaction request and a posting execution service posts a message including the posting to the ledger interoperability service; encrypting and providing the encrypted message to the distributed banking ledger; receiving an encrypted response message from the distributed banking ledger; decrypting and passing the encrypted response message to the posting execution service, wherein the posting execution service provides the posting, a transaction level status, and/or a posting level

Abstract: Distributed ledger cores are disclosed.

Abstract: Systems and methods for the application of distributed ledgers for network payments as financial exchange settlement and reconciliation are disclosed. In one embodiment, a method for processing network payments using a distributed ledger may include: (1) a payment originator initiating a payment instruction to a payment beneficiary; (2) a payment originator bank posting and committing the payment instruction to a distributed ledger on a peer-to-peer network; (3) the payment beneficiary bank posting and committing the payment instruction to the distributed ledger on a peer-to-peer network; and (4) the payment originator bank validating and processing the payment through a payment originator bank internal system and debiting an originator account.

Abstract: Anti-CD223 antibodies overcome immune suppression in cancer patients. The anti-CD223 antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies.

Abstract: Systems and methods for the application of distributed ledgers for network payments as financial exchange settlement and reconciliation are disclosed. In one embodiment, a method for processing network payments using a distributed ledger may include: (1) a payment originator initiating a payment instruction to a payment beneficiary; (2) a payment originator bank posting and committing the payment instruction to a distributed ledger on a peer-to-peer network; (3) the payment beneficiary bank posting and committing the payment instruction to the distributed ledger on a peer-to-peer network; and (4) the payment originator bank validating and processing the payment through a payment originator bank internal system and debiting an originator account.

Abstract: Combinations of anti-cancer antibodies and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies.

Abstract: A method for coupling a fiber strength member umbilical cable to a subsea equipment load transfer device includes separating fibers of the strength member for a selected axial distance at an end of the umbilical cable. At least one fiber loop is formed around a load transfer element of the load transfer device. Ends of the fiber forming the at least one fiber loop are woven into the separated fibers of the end of the umbilical cable. A length of the woven ends from an initial attachment point selected to provide a connection having a selected breaking strength.

Abstract: Mammals with cancer are treated with an antibody which specifically binds to CD223 protein and inhibits negative T cell regulatory function of CD223. The mammal may be a human. The antibody may be a monoclonal antibody. The amount of the antibody administered may be sufficient to enhance an immune T cell response to the cancer.

Abstract: Methods for treating autoimmune disease using one or more inhibitor of STAT3 are provided herein. Also disclosed are methods for diagnosing and monitoring autoimmune disease or the propensity to develop autoimmune disease in a subject. The present invention demonstrates that inhibition of STAT3 prevents development of autoimmune disease in vivo. Based on this finding, Stat3 inhibitors can be used to treat and/or diagnose autoimmune disease in a subject.

Abstract: Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.

Abstract: Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.