Abstract: The present invention relates to antibodies binding to IL13 and IL22. The invention provides novel multi-specific antibodies that bind to both IL13 and IL22 and compositions comprising an antibody that binds to IL13 and an antibody that binds to IL22. The invention further relates to therapeutic uses of the combination of anti-IL13 and anti-IL22 antibodies and multi-specific antibodies that bind to both IL13 and IL22.

Abstract: The present invention relates to antibodies binding to IL22 and inhibiting its interaction with one or more of its natural ligands Specific examples of such antibodies are provided. The therapeutic uses of the antibodies and methods of generating such C are also provided.

Abstract: Methods and systems are described. A method includes accessing training data samples that includes a plurality of transaction laundering associated features and generating random samples, training a first plurality of different models to identify transaction laundering merchants based on random samples generated from each of the training data samples, training a second plurality of different models to identify the transaction laundering merchants based on the training data, generating a transaction laundering classification for a merchant from each of the first plurality of models and each of the second plurality of models, generating a first model group classification based on a first majority vote on transaction laundering classifications from the first plurality of models, and generating a second model group classification based on a second majority vote on transaction laundering classifications from the second plurality of models. A likelihood that the merchant is a transaction launderer is determined.

Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory anti-KLK5 antibodies and their use in the treatment of Netherton disease, atopic dermatitis and cancer.

Abstract: The present invention relates to antibodies which bind and inhibit KLK5 and methods of using the same to treat diseases caused by KLK5 imbalance. In particular, the present invention relates to inhibitory antibodies binding KLK5 and their use in the treatment of Netherton disease, atopic dermatitis and cancer.

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

Abstract: A portable handheld device receives from a central repository, information on a failed hardware component of a computational device, wherein the information includes an authentication code to permit access to the failed hardware component and a time window in which the failed hardware component is permitted to be accessed. The portable handheld device uses the authentication code to access the failed hardware component for repair or replacement during the time window.

Abstract: A portable handheld device receives from a central repository, information on a failed hardware component of a computational device, wherein the information includes an authentication code to permit access to the failed hardware component and a time window in which the failed hardware component is permitted to be accessed. The portable handheld device uses the authentication code to access the failed hardware component for repair or replacement during the time window.

Abstract: Methods and systems are described. A method includes accessing training data samples that includes a plurality of transaction laundering associated features and generating random samples, training a first plurality of different models to identify transaction laundering merchants based on random samples generated from each of the training data samples, training a second plurality of different models to identify the transaction laundering merchants based on the training data, generating a transaction laundering classification for a merchant from each of the first plurality of models and each of the second plurality of models, generating a first model group classification based on a first majority vote on transaction laundering classifications from the first plurality of models, and generating a second model group classification based on a second majority vote on transaction laundering classifications from the second plurality of models. A likelihood that the merchant is a transaction launderer is determined.

Abstract: This disclosure provides a sorbent for at least one metal. The sorbent includes a core particle and a ceramic nanoparticulate cation exchanger for at least one metal that is disposed about the core particle. The core particle is chosen from titanium dioxide, alumina, iron oxide, and combinations thereof.

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

Abstract: The present invention generally relates to systems and methods for determining and analyzing sport related activities in conjunction with low latency transmission and processing. Specifically, embodiments of the present invention utilize sensor units placed on participants in a sporting activity in order to identify actions and/or movements made by the participants and analyze those actions and/or movements. In certain embodiments, the system is further configured to transmit the analyzed data associated with those actions and/or movements such that a group of end users (e.g., broadcast viewers, users of a mobile application) can consume the data in real time or near real time.

Abstract: An out-of-band to optical conversion component is provided that uses a transmit disable signal and a receive loss of signal (LOS) signal built into optical small form-factor pluggable transceiver and cable to pass the out-of-band protocol between serial attached SCSI enclosures. The transmit disable signal, when asserted, turns off the optical output, while the receive LOS signal detects the loss of signal. The out-of-band to optical conversion component sits in line on the serial attached SCSI data traffic and strips off the out-of-band signals from the serial attached SCSI expander so that only data flows over the optical cable. The out-of-band to optical conversion component sends the out-of-band signals to the other enclosure using the transmit disable pin on the small form-factor pluggable transceiver and cable. The other enclosure receives the message on the receive LOS signal and transmit it back onto the serial attached SCSI receive data pair.

Abstract: A method for managing business rigor for a financial institution includes receiving business rigor data based on activities to implement a plurality of core products. A performance table, unit cost report, and summary report are created or updated based on the business rigor data. The performance table may include data based on an analysis of the business rigor data; the unit cost report may include a cost report based on the performance table data; and the summary report may include a report based on the unit cost report. The summary report is presented in order to improve the business rigor data.

Abstract: A node has at least one memory module comprising at least one reflective memory region configured to reflect at least one reflective memory region of one or more other nodes, and the node and the one or more other nodes being configured to communicate on a packet-based serial point-to-point topology network. The node also comprises at least one network switch configured to provide at least two links each configured to connect to at least one non-host peer node on the network, multicast to the one or more other nodes at least one change to the at least one reflective memory region, receive from the one or more other nodes at least one other change to the at least one reflective memory region, and communicate to the at least one memory module the received at least one other change to the at least one reflective memory region.

Abstract: A mechanism is provided for providing reliable redundant data communications. The mechanism issues a request for data to a set of powered elements using a set of secondary communication channels in response to a reduction in a level of communications being detected. The set of secondary communication channels comprises one or more alternating current power lines and the request is sent as data injected onto the alternating current power lines to the set of powered elements. The mechanism receives the data using the set of secondary communication channels from the set of powered elements, analyzes the data to determine a set of recovery actions to restore the level of communications, and issues the set of recovery actions to the set of powered elements using the set of secondary communication channels.

Abstract: A process for stabilizing pyrolysis oil includes hydrogenating fast pyrolysis oil with hydrogen reactant in the presence of ruthenium metal catalyst at a temperature of at least about 70° C. and at a pressure of at least about 600 psig to form a hydrogenated fast pyrolysis oil exhibiting an increase in viscosity of less than 10% after accelerated stability testing at 80° C. for 24 hours. The resulting hydrogenated fast pyrolysis oil can be characterized as stabilized to viscosity increase, and can be provided as a bio fuel oil.

Abstract: This is directed to systems, processes, machines, and other means that stabilize a magnetic fuel canister. The invention can prevent a magnetic fuel canister from moving during transit.

Abstract: A single fibre channel switch or serial attached SCSI expander applies zoning on the initiator ports to each of the two ports of one or more drives. The fibre channel switch or serial attached SCSI expander uses zoning to connect both ports of each drive to a single expander and set the zones in the expander such that each zone includes at least one initiator port and one drive port.

Abstract: A method to communicate information within a data storage system comprising a plurality of enclosures, wherein the method defines and stores a first waveform comprising a frequency FB, a second waveform comprising a frequency F0 wherein that second waveform is decoded to mean a bit comprising a first value, and a third waveform comprising a frequency F1, wherein that third waveform is decoded to mean a bit comprising a second value. The method transmits by an initiating enclosure a byte of data encoded as eight data waveforms, wherein each of those data waveforms comprises the frequency FB in combination with either the frequency F1 or the frequency F0.