Abstract: An asset tag comprises a first short-range wireless interface configured to transmit a wireless signal with a predetermined periodicity, the wireless signals including a tag ID unique to the asset tag, and an optical sensor. The asset tag can include processing circuitry, coupled to the first short-range wireless interface and to the optical sensor and a battery connected to an powering the first short-range wireless interface, optical sensor, and/or processing circuitry. The processing circuitry receives a first electrical signal from the optical sensor in response to the receipt of a first optical signal. The processing circuitry transmits first wireless signals including the tag ID via the first short-range wireless interface. A dispensing enclosure transmits the first optical signal for the or each asset within the dispensing enclosure, receives a respective first wireless signal and determines a set of Tag IDs of assets added or removed by user.

Abstract: An electric vehicle charging master controller includes an instruction processing unit, a user interface module, and a charging interface module. Electric vehicle (EV) charging equipment is external to the controller. The instruction processing unit is configured to execute instructions for charging electric vehicles (EVs). The charging interface module is configured to receive information from the instruction processing unit and transmit information to the EV charging equipment. The instruction processing unit is configured to transmit information to the charging interface module, which is designed to cause the EV charging equipment to direct charging current to the plurality of EVs, one at a time. The instruction processing unit is also configured to transmit information to the charging interface module designed to cause the EV charging equipment to stop the charging current to each EV when a charging cessation criterion has been met.

Abstract: The present disclosure relates to charging accessory device for the aerosol delivery device and related systems, methods, apparatuses, and computer program products for providing interactive services for aerosol delivery devices. For example, a method may include a computing device establishing communication with a charging accessory device for an aerosol delivery device; receiving usage data for the aerosol delivery device provided by the charging accessory device; generating social data based on the usage data; and sending the social data to a social networking service including a community of aerosol delivery device users.

Abstract: The present invention is inter alia concerned with a combination of a CBP/p300 bromodomain inhibitor and an EGFR inhibitor for use in the treatment of a patient suffering from NSCLC, wherein the NSCLC exhibits an oncogenic alteration in the EGFR.

Abstract: A secure asset supply cabinet comprises bins for holding assets and a programmable lock. The programmable lock comprises a short range wireless interface (e.g. RFID or NFC) and a physical lock actuatable by processing circuitry. The programmable lock receives an unlock code via the short range wireless interface, e.g. by a user entering credentials on a portable wireless device. The received unlock code is authenticated based on an authentication or lock code. If the unlock code is authentic, the physical lock is actuated to unlock the asset supply cabinet. Each bin may have a wireless asset tag on its surface. Each tag may comprise a user-actuatable button and be encoded with a unique ID. When a user performs a predetermined gesture with the button, such as pressing it twice, a restock message including the ID is transmitted to a wireless access point.

Abstract: The present invention is inter alia concerned with (i) a combination of a CBP/p300 bromodomain inhibitor and a KRAS inhibitor for use in the treatment of a patient suffering from cancer, wherein the cancer exhibits an oncogenic alteration in the KRAS; (ii) a kit comprising (a) a pharmaceutical dosage form comprising a CBP/p300 bromodomain inhibitor and (b) a pharmaceutical dosage form comprising a KRAS inhibitor, and (iii) a pharmaceutical dosage form comprising a CBP/p300 bromodomain inhibitor and a a KRAS inhibitor.

Abstract: The present disclosure refers to a system for a drug delivery device comprising a housing and a cartridge holder which may contain a cartridge filled with a medicament. The housing and the cartridge holder comprise a coding interface for dedicating a certain cartridge to a certain housing and a bayonet type attachment interface for releasably attaching the cartridge holder to the housing by an attachment movement comprising a first stage and a second stage. The system further comprises at least one compliant spring member arranged and designed such that it is strained during the first and/or the second stage of the attachment movement at least if the housing coding element does not match the holder coding element, and wherein the compliant spring member is arranged and designed to move the cartridge holder relative to the housing in a direction contrary to the attachment movement when relaxing.

Abstract: The present disclosure relates to aerosol delivery devices comprising a power unit and a cartridge that is configured for engagement with the power unit. In particular, the cartridge can be configured for rotation about a longitudinal axis thereof so as to be insertable into a chamber of the power unit in a plurality of different orientations. Further, the aerosol delivery device can include processing circuitry that can be configured for detection of the cartridge orientation and execution of a control function assigned to the respective orientation.

Abstract: The present disclosure relates to an aerosol delivery device and related methods and computer program products for controlling an aerosol delivery device based on input characteristics. For example, a method may include an aerosol delivery device determining a characteristic of a user input to the aerosol delivery device. The method may further include the aerosol delivery device determining a control function having a defined association with the characteristic. The method may additionally include the aerosol delivery device performing the control function in response to the user input.

Abstract: An aerosol delivery device is provided that includes a power source, a heating element, a switch coupled to and between the power source and the heating element, and processing circuitry coupled to the switch. The processing circuitry outputs a PWM signal during a heating time period to cause the switch to switchably connect and disconnect the output voltage to the heating element to power the heating element. The processing circuitry outputs a pulse of known current to the heating element, and measure voltage across the heating element, between adjacent pulses of the PWM signal. And the processing circuitry calculates the resistance of the heating element based on the known current and the voltage, calculates the temperature of the heating element based on the resistance, and adjusts a duty cycle of the PWM signal when the temperature deviates from a predetermined target.

Abstract: The present disclosure relates to charging accessory device for the aerosol delivery device and related systems, methods, apparatuses, and computer program products for providing interactive services for aerosol delivery devices. For example, a method may include a computing device establishing communication with a charging accessory device for an aerosol delivery device; receiving usage data for the aerosol delivery device provided by the charging accessory device; generating social data based on the usage data; and sending the social data to a social networking service including a community of aerosol delivery device users.

Abstract: An example via contact patterning method includes providing a pattern of alternating trench contacts and gates over a support structure. For each pair of adjacent trench contacts and gates, a trench contact is electrically insulated from an adjacent gate by a dielectric material and/or multiple layers of different dielectric materials, and the gates are recessed with respect to the trench contacts. The method further includes wrapping a protective layer of one or more dielectric materials, and a sacrificial helmet material on top of the trench contacts to protect them during the via contact patterning and etch processes for forming via contacts over one or more gates. Such a method may advantageously allow increasing the edge placement error margin for forming via contacts of metallization stacks.

Abstract: An application specific integrated circuit (ASIC) chip includes: a systolic array of cells; and multiple controllable bus lines configured to convey data among the systolic array of cells, in which the systolic array of cells is arranged in multiple tiles, each tile of the multiple tiles including 1) a corresponding sub array of cells of the systolic array of cells, 2) a corresponding subset of controllable bus lines of the multiple controllable bus lines, and 3) memory coupled to the subarray of cells.

Abstract: An aerosol delivery device is provided. The aerosol delivery device includes a power source, an aerosol production component, a sensor to produce measurements of atmospheric air pressure in an air flow path through at least one housing, and a switch coupled to and between the power source and the aerosol production component. The aerosol delivery device also includes processing circuitry that determines a difference between the measurements of atmospheric air pressure and a reference atmospheric air pressure. Only when the difference is at least a threshold difference, the processing circuitry outputs a signal to cause the switch to switchably connect and disconnect an output voltage from the power source to the aerosol production component to adjust power provided to the aerosol production component to a power target that is variable according to a predetermined relationship between the difference and the power target.

Abstract: Techniques are described for determining a duration for a transition and alteration of the appearance of a user interface (UI) from a first UI state to a second UI state over the transition duration according to a timing function that specifies different rates of change in appearance over the course of the transition and is derived by adjusting a master timing function that is used to control a plurality of transitions in the UI to span the transition duration for the transition. A time value of an inflection point within the timing function is determined and the transition duration is divided into a first portion and a second portion so that the first portion extends from the beginning of the transition duration to the time value of the inflection point, and the second portion extends from the time value of the inflection point to the end of the transition duration.

Abstract: An aerosol delivery device is provided that includes a power source, a heating element, a switch coupled to and between the power source and the heating element, and processing circuitry coupled to the switch. The processing circuitry outputs a PWM signal during a heating time period to cause the switch to switchably connect and disconnect the output voltage to the heating element to power the heating element. The processing circuitry outputs a pulse of known current to the heating element, and measure voltage across the heating element, between adjacent pulses of the PWM signal. And the processing circuitry calculates the resistance of the heating element based on the known current and the voltage, calculates the temperature of the heating element based on the resistance, and adjusts a duty cycle of the PWM signal when the temperature deviates from a predetermined target.

Abstract: The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.

Abstract: The present invention relates to a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof: formula (I) and to pharmaceutical compositions comprising a compound of formula (I), as well as to the use of a compound of formula (I), or a pharmaceutically acceptable salt, solvate, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, in the treatment of cancer. Further aspects of the present invention include combination therapies in which a compound of formula (I), as well as to the use of a compound of formula (I), or a pharmaceutically acceptable salt, solvate, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, is used in combination with a known anti-cancer agent.

Abstract: An aerosol delivery device is provided. The aerosol delivery device includes a power source, an aerosol production component, a sensor to produce measurements of atmospheric air pressure in an air flow path through at least one housing, and a switch coupled to and between the power source and the aerosol production component. The aerosol delivery device also includes processing circuitry that determines a difference between the measurements of atmospheric air pressure and a reference atmospheric air pressure. Only when the difference is at least a threshold difference, the processing circuitry outputs a signal to cause the switch to switchably connect and disconnect an output voltage from the power source to the aerosol production component to adjust power provided to the aerosol production component to a power target that is variable according to a predetermined relationship between the difference and the power target.

Abstract: The present invention relates to compound-linker constructs and antibody-drug-conjugates of compounds of formula (I) that are useful as modulators of STING (Stimulator of Interferon Genes).