Patents by Inventor Charles A. Omer

Charles A. Omer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding cytosine deaminase
    Patent number: 7556955
    Abstract: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: July 7, 2009
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: Yuqiao Shen, Sylvie Laquerre, Amy M. Delaney, Charles A. Omer
  • Antibody that specifically binds to Cytosine deaminase
    Patent number: 7414113
    Abstract: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: August 19, 2008
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: Yuqiao Shen, Sylvie Laquerre, Amy M. Delaney, Charles A. Omer
  • Candida Kefyr Cytosine Deaminase
    Publication number: 20070026491
    Abstract: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.
    Type: Application
    Filed: July 20, 2006
    Publication date: February 1, 2007
    Applicant: Onyx Pharmaceuticals, Inc.
    Inventors: Yuqiao Shen, Sylvie Laquerre, Charles Omer, Amy Delaney
  • Candida Kefyr Cytosine Deaminase
    Publication number: 20060286592
    Abstract: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.
    Type: Application
    Filed: July 20, 2006
    Publication date: December 21, 2006
    Applicant: Onyx Pharmaceuticals, Inc.
    Inventors: Yuqiao Shen, Sylvie Laquerre, Charles Omer, Amy Delaney
  • cytosine deaminase
    Patent number: 7141404
    Abstract: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: November 28, 2006
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: Yuqiao Shen, Sylvie Laquerre, Amy M. Delaney, Charles A. Omer
  • Candida kefyr cytosine deaminase
    Publication number: 20040180418
    Abstract: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.
    Type: Application
    Filed: December 22, 2003
    Publication date: September 16, 2004
    Applicant: Onyx Pharmaceuticals, Inc.
    Inventors: Yuqiao Shen, Sylvie Laquerre, Charles A. Omer, Amy M. Delaney
  • Genes for the subunits of human farnesyl-protein transferase
    Patent number: 5821118
    Abstract: The present invention relates to an assay useful in determining the farnesyl-protein transferase inhibitory activity of pharmaceutical agents. The assay employs purified human farnesyl-protein transferase which is prepared by gene expression in Escherichia coli.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: October 13, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Charles A. Omer, Ronald E. Diehl, Jackson B. Gibbs, Nancy E. Kohl
  • Protein prenyltransferase
    Patent number: 5789558
    Abstract: The present invention relates, in general, to a protein prenyltransferase and, in particular, to protein geranylgeranyltransferase (GGTase-I) and to a nucleic acid sequence encoding same. The invention also relates to methods of producing GGTase-I and geranylgeranyl modified polypeptides. The invention further relates to a method of screening compounds for the ability to alter GGTase-I activity.
    Type: Grant
    Filed: January 31, 1994
    Date of Patent: August 4, 1998
    Assignees: Merck & Co., Inc., Duke University
    Inventors: Patrick J. Casey, Fang Zhang, Ronald E. Diehl, Nancy E. Kohl, Charles A. Omer
  • Inhibitors of prenyl-protein transferases
    Patent number: 5574025
    Abstract: The compounds disclosed inhibit the prenylation of several proteins. These compounds are potent inhibitors of famesyl-protein transferase and geranylgeranyl-protein transferase. Further contained in this invention are chemotherapeutic compositions containing these prenyl-transferase inhibitors and methods for their production.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: November 12, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Neville J. Anthony, Robert P. Gomez, Charles A. Omer
  • Constitutive expression of P450soy and ferredoxin-soy in Streptomyces
    Patent number: 5466590
    Abstract: The present invention provides a method of making a recombinant organism capable of oxidizing organic chemicals by constitutive production of proteins capable of performing oxidation. A recombinant organism and a method of oxidizing organic chemicals are also provided. The present invention is useful in bioremediation to remove waste chemicals from the environment.
    Type: Grant
    Filed: August 6, 1993
    Date of Patent: November 14, 1995
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Fateme S. Sariaslani, Michael K. Trower, Charles A. Omer
  • Expression of herbicide metabolizing cytochromes P450
    Patent number: 5349127
    Abstract: DNA sequences encoding herbicide metabolizing cytochrome P450 enzymes and iron-sulfur proteins that donate electrons to these enzymes, were introduced into plants and microorganisms rendering them able to produce the encoded gene products and to metabolize herbicides.
    Type: Grant
    Filed: October 26, 1992
    Date of Patent: September 20, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Caroline Dean, Patricia A. Harder, Kenneth J. Leto, Daniel P. O'Keefe, Charles A. Omer, James A. Romesser, James M. Tepperman
  • Expression of herbicide metabolizing cytochromes
    Patent number: 5212296
    Abstract: DNA sequences encoding herbicide metabolizing cytochrome P450 enzymes and iron-sulfur proteins that donate electrons to these enzymes, were introduced into plants and microorganisms rendering them able to produce the encoded gene products and to metabolize herbicides.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: May 18, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Caroline Dean, Patricia A. Harder, Kenneth J. Leto, Daniel P. O'Keefe, Charles A. Omer, James A. Romesser, James M. Tepperman
  • Process for inducing cytochrome P-450 enzymes in streptomyces bacteria and determining the mutagenicity of chemicals
    Patent number: 5169755
    Abstract: A process for inducting cytochrome P-450 enzyme production in bacteria of the genus Streptomyces using inducers such as soybean flour, genistein or genistin is described. Uses for the cytochrome P-450 enzymes produced are also discussed as is a process for using genetically engineered Streptomyces to determine the mutagenicity of chemicals.
    Type: Grant
    Filed: June 16, 1988
    Date of Patent: December 8, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Fateme S. Sariaslani, Steven E. Buchholz, Charles A. Omer, Paul V. Viitanen