Abstract: The present disclosure provides a monoclonal antibody which binds to porcine CD163 for use in the treatment or prevention of Porcine Reproductive and Respiratory Syndrome (PRRS) virus infection in a pig. Preferred antibodies comprise an antigen binding domain which binds to porcine CD163, said antigen binding domain comprising at least one heavy chain variable region which comprises three complementarity determining regions (CDRs), wherein said heavy chain variable region comprises a variable heavy (VH) CDR2 that comprises the amino acid sequence XYAD or XYAE or XYAN, in which X can be any amino acid. Nucleic acid molecules, expression vectors and compositions are also provided.

Abstract: The present invention provides a protein construct comprising: a) at least two monomers each of which comprises a C-type lectin domain of CD23, wherein each monomer can bind to IgE; and b) an entity which can bind to the neonatal Fc receptor (FcRn); wherein said protein construct comprises a linker, and wherein said linker is used to link said monomer comprising a C-type lectin domain of CD23 to said entity which can bind to FcRn. Therapeutic uses of the constructs, for example in anti-IgE therapy or for use in the treatment or prevention of an IgE related disease or condition are also provided.

Abstract: Provided herein are compositions, including Nedocromil Sodium, and methods to prevent, limit onset, and/or treat Pancreatic Cancer in a subject.

Abstract: A transmission tilt control device includes a transmission rotatably coupled to an airframe of a helicopter, a rotor mast coupled to the transmission, and an actuator coupled between the transmission and the airframe. The actuator being configured to rotate the transmission fore and aft about a tilt axis that is perpendicular to an axis of rotation of the rotor mast.

Abstract: A transmission tilt control device includes a transmission rotatably coupled to an airframe of a helicopter, a rotor mast coupled to the transmission, and an actuator coupled between the transmission and the airframe. The actuator being configured to rotate the transmission fore and aft about a tilt axis that is perpendicular to an axis of rotation of the rotor mast.

Abstract: A pressure-blocking feedthru that is exposable to varying temperatures and pressures includes various components. For example, the pressure-blocking feedthru might include pressure-blocking assemblies that each include a respective pressure-barrier shell and insulated pin assembly. The pressure-blocking feedthru also includes an interface assembly that couples the pressure-blocking assemblies to one another. The interface assembly includes a double-ended socket for coupling the insulated pin assemblies and a sleeve that circumscribes the doubled ended socket and at least part of the first and the second ceramic pin assemblies. In addition, the pressure-blocking assemblies might each be connected to a cable-connection assembly that employs a pressure-balanced cable termination.

Abstract: Various cable termination assemblies are disclosed. The cable termination assembly can include a pin, a sealing element, a compression plate, and an insulator. The compression plate and the sealing element can be seated on the pin and form a substantially gas or liquid-tight seal with the pin. The insulator can have a feature that engages with a feature on the pin. The insulator can be advanced along the pin to compress the compression plate against the sealing element.

Abstract: A pressure-blocking feedthru that is exposable to varying temperatures and pressures includes various components. For example, the pressure-blocking feedthru might include pressure-blocking assemblies that each include a respective pressure-barrier shell and insulated pin assembly. The pressure-blocking feedthru also includes an interface assembly that couples the pressure-blocking assemblies to one another. The interface assembly includes a double-ended socket for coupling the insulated pin assemblies and a sleeve that circumscribes the doubled ended socket and at least part of the first and the second ceramic pin assemblies. In addition, the pressure-blocking assemblies might each be connected to a cable-connection assembly that employs a pressure-balanced cable termination.

Abstract: A light emitting system comprises an LED-based light emitting device and a controller for controlling operation of the device. The device comprises at least two LEDs that are operable to generate light of different colors that contribute to the emission product of the device. The controller is operable to control light emission from the LEDs in response to the measured intensity of the first and second color light contributions in the emission product. To measure the individual light contributions the controller is operable to interrupt, or at least change, light emission from one LED for a selected time period and during this time period to measure the intensity of the emission product of the device. The intensity of light of the first and second color can be determined by comparing the measured intensity with the measured intensity when the light emission from the other LED is interrupted or changed.

Abstract: Embodiments of reinforced composite structures for aircrafts and methods for making such reinforced composite structures are provided herein. A reinforced composite structure for an aircraft comprises a fiber reinforced composite stringer. The fiber reinforced composite stringer comprises a beam body portion and a runout portion that extends from the beam body portion in a first direction. The beam body and runout portions are defined by projection of a variable I-shaped cross-section in the first direction along at least a portion of an entire combined length of the beam body and runout portions. The variable I-shaped cross-section has a cap section, a foot section, and a web section that extends between the cap and foot sections. The variable I-shaped cross-section is configured such that a height of the web section tapers in the first direction along at least a portion of an entire length of the runout portion.

Abstract: A building which has as a wall of its envelope, a wall of a size of at least 2.

Abstract: Embodiments of reinforced composite structures for aircrafts and methods for making such reinforced composite structures are provided herein. A reinforced composite structure for an aircraft comprises a fiber reinforced composite stringer. The fiber reinforced composite stringer comprises a beam body portion and a runout portion that extends from the beam body portion in a first direction. The beam body and runout portions are defined by projection of a variable I-shaped cross-section in the first direction along at least a portion of an entire combined length of the beam body and runout portions. The variable I-shaped cross-section has a cap section, a foot section, and a web section that extends between the cap and foot sections. The variable I-shaped cross-section is configured such that a height of the web section tapers in the first direction along at least a portion of an entire length of the runout portion.

Abstract: A method for fabricating a self assembling light emitting diode lens is disclosed. The method includes providing a first fluid with a first viscosity and a second fluid with a second viscosity. The refractive index of the first fluid is the same as the refractive index of the second fluid. Then the first fluid and the second fluid are blended in a predetermined ratio to obtain a third fluid with a third viscosity. Then the third fluid is dispended on a light emitting diode, which is disposed on a substrate. The third fluid is cured to form a lens on the light emitting diode. The shape of the lens is controlled by the third viscosity.

Abstract: Systems and methods are disclosed for substantially uniformly lighting a substantially cylindrical cavity using a minimal amount of light sources. The primary technique disclosed utilizes directing light through a light pipe where is dispersed appropriately. Further, techniques are disclosed for performing the above functions when the substantially cylindrical cavity is partially filled with an opaque obstruction.

Abstract: A light emitting system comprises an LED-based light emitting device and a controller for controlling operation of the device. The device comprises at least two LEDs that are operable to generate light of different colors that contribute to the emission product of the device. The controller is operable to control light emission from the LEDs in response to the measured intensity of the first and second color light contributions in the emission product. To measure the individual light contributions the controller is operable to interrupt, or at least change, light emission from one LED for a selected time period and during this time period to measure the intensity of the emission product of the device. The intensity of light of the first and second color can be determined by comparing the measured intensity with the measured intensity when the light emission from the other LED is interrupted or changed.

Abstract: An LED-based light emitting device comprises: a substrate; at least one LED die mounted to the substrate; at least one bond wire that electrically connects the LED die; and a light transmissive material (silicone) encapsulating the at least one LED die and at least one bond wire. The at least one bond wire has a hook-shaped portion that loops back on itself.

Abstract: A combination vehicle wheel well cover and mud flap device, comprising a semi-circular wheel well insert and a wrap-around rear flap portion that acts as a protective guard for flying debris ejected from the rotating rear wheel. The device provides a means to customize a vehicle by providing coverage of a rear tire and rim, changing the aesthetic nature of the vehicle, while also improving aerodynamic qualities therefor and further protecting the body from ejected rocks and dirt. A wrap-around portion attaches to the vehicle wheel well and forms a rear mounted mud flap, and also provides a lip for attachment of a wheel well cover. The cover may be removably attached via a row of fasteners to allow the cover to be removed without disassembling the entire assembly.

Abstract: A wagering system provided by a betting organiser for one or more players to bet on an event. Each of the players provides the betting organiser with monetary value in order to be eligible to participate in the wagering system. The betting organiser accumulates the monetary value provided by each of the players into a centralised prize pool prior to the commencement of the event. The event comprises a plurality of integers having at least first and second possible outcomes, whereby, if the first outcome occurs, the players who wagered on the first outcome win and, if the second outcome occurs, the players who wagered on the first outcome lose. At the conclusion of each integer, a pay off dividend is credited to each winning player. At the conclusion of the event, the centralised prize pool is distributed to the players with the highest accumulated value of credited pay off dividends.

Abstract: A tissue treatment system has a radio frequency generator and a handheld treatment instrument that generates a gas plasma jet for delivering thermal energy to a tissue surface to be treated. Incorporated in the housing for the generator is a calibration device for adjusting the energy output of the generator, if necessary, at the beginning of a treatment session. The calibration device has a target element with a target surface, a transducer for sensing changes in temperature of the target element with respect to the temperature of a reference element, and an energy output adjuster for adjusting the radio frequency energy output of the generator in response to a calibration signal generated by the transducer. The generator housing has a receptacle for locating the nozzle of the handheld instrument in juxtaposition with the target element so that when a plasma burst is generated as part of a calibration sequence it is incident on the target surface.

Abstract: An electrosurgical generator has output terminals for connection to active and return electrodes respectively of an electrosurgical instrument and, connected to the output terminals via at least one isolation capacitor, a radio frequency (r.f.) source which may be pulsed by a pulsing circuit. To permit tissue removal at a high rate, the source and the pulsing circuit are arranged so as to generate a pulsed r.f. output signal having a peak-to-peak voltage of at least 1250V, a mark-to-space ratio not more than 1:1, and a pulse length not more than 100 ?s.