Abstract: Systems and methods are disclosed for predicting the location, onset, or change of coronary lesions from factors like vessel geometry, physiology, and hemodynamics. One method includes: acquiring, for each of a plurality of individuals, a geometric model, blood flow characteristics, and plaque information for part of the individual's vascular system; training a machine learning algorithm based on the geometric models and blood flow characteristics for each of the plurality of individuals, and features predictive of the presence of plaque within the geometric models and blood flow characteristics of the plurality of individuals; acquiring, for a patient, a geometric model and blood flow characteristics for part of the patient's vascular system; and executing the machine learning algorithm on the patient's geometric model and blood flow characteristics to determine, based on the predictive features, plaque information of the patient for at least one point in the patient's geometric model.

Abstract: Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.

Abstract: Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements.

Abstract: A docking station for a hand-held filament extension atomizer device includes a receiver to receive the device, station electronics, a recharging point for the device arranged to connect with a power source of the device, a power connection to an alternating current power source, and a cleaning reservoir of cleaning solution. A method of operating hand-held dispenser to dispense fluid as a mist includes receiving a signal at a motor contained in a casing in response to a user triggering an actuator on the casing, activating the motor to provide fluid to a filament extension atomizer contained in the case from a reservoir contained in the casing, the motor to cause the filament extension atomizer to generate a mist, and using an air source contained in the casing arranged adjacent the filament extension atomizer to provide air flow to direct the mist to a nozzle that is arranged to allow the mist to exit the casing.

Abstract: An adapter block assembly includes an adapter block, a circuit board arrangement, and a cover attached to the adapter block so that the circuit board arrangement is held to the adapter block by the cover. Contact assemblies can be disposed between the adapter block and the circuit board arrangement. The cover can be latched, heat staked, or otherwise secured to the adapter block. Each component of the adapter block assembly can include one or more parts (e.g., multiple adapter blocks, multiple circuit boards, and/or multiple cover pieces).

Abstract: Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Abstract: Systems and methods are disclosed for assessing cardiovascular disease and treatment effectiveness based on adipose tissue. One method includes identifying a vascular bed of interest in a patient's vasculature; receiving a medical image of the patient's identified vascular bed of interest; identifying adipose tissue in the received medical image; receiving a geometric vascular model comprising a representation of the patient's identified vascular bed of interest; and computing an inflammation index associated with the geometric vascular model, using the identified adipose tissue.

Abstract: An inferior vena cava filter (340) for use in the inferior vena cava (4) to capture thrombus (8) passing through the inferior vena cava (4) towards the heart and lungs to prevent pulmonary embolism comprises a proximal support hoop (302), a distal support hoop (312) and a plurality of support struts (303) extending between the proximal support hoop (302) and the distal support hoop (312). The filter (340) also comprises a plurality of capture arms (121) which are movable from a capturing configuration to an open configuration. The capture arms (121) are biased towards the open configuration. A biodegradable suture holds the capture arms (121) in the capturing configuration.

Abstract: A hand-held dispenser to dispense fluid includes a casing to fit into a hand of a user, a nozzle in the casing to dispense a mist, a fluid reservoir contained in the casing to hold a fluid to be turned into the mist, a filament extension atomizer contained in the casing to generate the mist, an air source contained in the casing to provide air flow to direct the mist to the nozzle, a motor contained in the casing to operate the filament extension atomizer, an actuator positioned on the casing to activate the dispenser, a control circuit contained in the casing to receive a signal from the actuator and to send a signal to the motor to cause the motor to actuate, and a power source contained in the casing to provide power to the motor upon receive a signal from the control circuit.

Abstract: Disclosed herein is an enclosure including a housing for dissipating heat from first and second heat generating components located on first and second circuit boards, respectively. In the enclosure, a first heat sink plate and a second heat sink plate are spring biased apart from one another. A maximum spring biasing distance between the first heat sink plate and the second heat sink plate is greater than a distance between the interior side of the front wall and the interior side of the back wall of the housing.

Abstract: Embodiments of the invention are directed to systems, methods, and computer program products for automating bulk data conversion processes of one or more database management systems. Data conversion projects of focus may comprise conversion of a large bulk of data with a wide range in order of magnitude. The system is designed and driven by the present constraints of large data conversion and is based on principles of reviewability, minimization of manual review and development work, persistence of data stores for data result comparison, process optimization for downstream review and certification, timely execution, and allowance for concurrent development by multiple systems and resources.

Abstract: A fixture is for forming a fiber optic array that defines a plurality of discrete fibers extending from a spaced-apart arrangement to a consolidated arrangement wherein the fibers are layered next to each other for a further ribbonizing process. The fixture includes a pair of contact blades that are configured to slide along a direction transverse to the longitudinal axes of the fibers for consolidating the fibers.

Abstract: Methods, systems and apparatus, including computer programs encoded on computer storage media for fleet management of unmanned aerial vehicles, including flight authorization. One of the methods includes maintaining one or more rules associated with authorizing UAVs to implement flight plans. A request to generate a flight plan associated with a job is received, the request including information indicating a flight pattern comprising, at least, one or more waypoints associated with geospatial references. The flight plan is generated based on the request, and an initial authorization check is determined based on the maintained rules and the generated flight plan. Upon a positive determination, access to the generated flight plan is provided by a ground control system, and the flight plan is implemented.

Abstract: Systems and methods are disclosed for providing personalized chemotherapy and drug delivery using computational fluid dynamics and medical imaging with machine learning from a vascular anatomical model. One method includes receiving a patient-specific anatomical model of at least one vessel of the patient and a target tissue where a drug is to be supplied; receiving patient-specific information defining the administration of a drug; deriving patient-specific data from the patient specific anatomical model and/or the patient; determining one or more blood flow characteristics in a vascular network leading to the one or more locations in the target tissue where drug delivery data will be estimated or measured, using the patient-specific anatomical model and the patient-specific data; and computing drug delivery data at the one or more locations in the target tissue using transportation, spatial, and/or temporal distribution of the drug particles.

Abstract: Systems and methods are disclosed for assessing cardiovascular disease and treatment effectiveness based on adipose tissue. One method includes identifying a vascular bed of interest in a patient's vasculature; receiving a medical image of the patient's identified vascular bed of interest; identifying adipose tissue in the received medical image; receiving a geometric vascular model comprising a representation of the patient's identified vascular bed of interest; and computing an inflammation index associated with the geometric vascular model, using the identified adipose tissue.

Abstract: Embodiments include systems and methods for determining cardiovascular information for a patient. A method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model.

Abstract: Embodiments include systems and methods for determining cardiovascular information for a patient. A method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model.

Abstract: A connector including two connector portions each including a ferrule and a latch, each latch including a distal end, and a proximal end, wherein the latch is pivotable about an intermediate connection portion; and a boot mounted to the connector portions, the boot movable longitudinally relative to the connector portions, wherein the boot causes the distal ends of the latch to pivot toward the ferrule of each connector portion as the boot is moved away from the connector portions. Front housings of the connector portions can each be rotated about the longitudinal axis of the ferrule without rotating the ferrule or the boot, to change the polarity of the two connector portions. The spacing between the two ferrules is adjustable. A holder holds the connector portions, the holder including side slots, the connector portions mounted to the holder by moving laterally to the side slots. The holder defines an area for receipt of a fiber optic cable when the ferrule is pushed in a direction toward the boot.

Abstract: Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.

Abstract: Embodiments include systems and methods for determining cardiovascular information for a patient. A method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of the patient's vasculature based on the patient-specific data; and creating a computational model of a blood flow characteristic based on the anatomic model.