Patents by Inventor Charles A. Wilkie

Charles A. Wilkie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective N-acylation of A82846 glygopeptides analogs
    Patent number: 7365053
    Abstract: The present invention provides a process for selectively acylating an A82846A, A82846B, A82846C or PA-42867-A glycopeptide at the N1, N2 or N3 positions and the monoacylated compounds prepared therefrom.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: April 29, 2008
    Assignee: Eli Lilly and Company
    Inventors: Richard Craig Thompson, Stephen Charles Wilkie, Mark James Zweifel
  • N1-modified glycopeptides
    Patent number: 6939947
    Abstract: The present invention is directed to N1-acylated derivatives of desleucylA82846B. These derivatives are useful as antibacterials.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: September 6, 2005
    Assignee: InterMune, Inc.
    Inventors: Richard Craig Thompson, Stephen Charles Wilkie
  • N1 modified glycopeptides
    Patent number: 6670446
    Abstract: Described herein are N′-acylated derivatives of desleucylA82846B. The compounds are useful as antibacterial agents.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: December 30, 2003
    Assignee: Eli Lilly and Company
    Inventors: Richard Craig Thompson, Stephen Charles Wilkie
  • Method to produce flame retardant styrenic polymers and product produced thereby
    Patent number: 6333385
    Abstract: Disclosed is a process for producing thermally stabilized styrenic polymers and products produced thereby wherein a pre-formed styrenic polymer is functionalized with a bifunctional Friedel-Crafts-type alkylation or acylation agent to yield a functionalized styrenic polymer. The functionalized polymer is admixed with a Friedel-Crafts-type catalyst, preferably a phosphate ester, and optionally a base, such that the functionalized polymer will experience inter- and intramolecular cross-linking reactions at elevated temperatures, thereby stabilizing the polymer from further thermal degradation.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: December 25, 2001
    Assignee: Marquette University
    Inventors: Charles A. Wilkie, Jin Zhu, Hongyang Yao, Michael A. McKinney
  • Alkylated hexapeptides
    Patent number: 5977063
    Abstract: The present invention is directed to N.sup.1 -alkylated derivatives of desleucyl A82846B. These derivatives are useful as antibacterials and also as starting materials from which further antibacterial compounds are prepared.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard Craig Thompson, Stephen Charles Wilkie
  • Glycopeptide hexapeptides
    Patent number: 5952310
    Abstract: The present invention is directed to glycopeptides and more particularly to derivatives of the glycopeptide A82846B. In these derivatives, the leucyl has been removed to create "hexapeptides" of A82846B and its N.sup.DISACC variations. These hexapeptides are useful as antibacterials and also as starting materials from which further antibacterial compounds are prepared.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard Craig Thompson, Stephen Charles Wilkie
  • Fire retardant polymeric resin comprising polymeric resins having grafted thereon salts of acidic monomers
    Patent number: 5457164
    Abstract: A fire retardant polymeric resin is disclosed. The resin comprises a polymer having grafted thereto a fire retardant effective amount of a monomer composition selected from among salts of acidic monomers, mixtures of salts of acidic monomers, and mixtures of acidic monomers and salts thereof. Related additives are also disclosed.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: October 10, 1995
    Assignee: Marquette University
    Inventor: Charles A. Wilkie
  • Method of selecting flame retardants for polymers
    Patent number: 4306878
    Abstract: A method for selecting a flame retardant for a polymer comprises using cross polarization and magic-angle sample spinning techniques to record well resolved .sup.31 P and .sup.13 C nuclear magnetic resonance spectra of the polymer before and after ignition; recording .sup.31 P and .sup.13 C NMR spectra of the combination of polymer and a known flame retardant before and after ignition; characterizing the chemical and physical changes that occur in the flame retardant and the polymer upon ignition and thereby determining the chemical basis by which the known flame retardant is operating and using that knowledge to select another flame retardant that will be effective for use with the polymer.
    Type: Grant
    Filed: August 29, 1980
    Date of Patent: December 22, 1981
    Inventors: Charles E. Brown, Charles A. Wilkie