Patents by Inventor Charles Allerson

Charles Allerson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4'-thionucleosides and oligomeric compounds
    Publication number: 20050130923
    Abstract: The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.
    Type: Application
    Filed: September 20, 2004
    Publication date: June 16, 2005
    Inventors: Balkrishen Bhat, Prasad Dande, Thazha Prakash, Charles Allerson, Eric Swayze, Richard Griffey
  • Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
    Publication number: 20050080246
    Abstract: The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
    Type: Application
    Filed: June 3, 2004
    Publication date: April 14, 2005
    Inventors: Charles Allerson, Balkrishen Bhat, Anne Eldrup, Muthiah Manoharan, Richard Griffey, Brenda Baker, Eric Swayze
  • Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
    Publication number: 20050026160
    Abstract: The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
    Type: Application
    Filed: November 4, 2003
    Publication date: February 3, 2005
    Inventors: Charles Allerson, Balkrishen Bhat, Anne Eldrup, Muthiah Manoharan, Richard Griffey, Brenda Baker, Eric Swayze
  • Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
    Publication number: 20040171570
    Abstract: Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.
    Type: Application
    Filed: November 4, 2003
    Publication date: September 2, 2004
    Inventors: Charles Allerson, Balkrishen Bhat, Anne B. Eldrup, Muthiah Manoharan, Richard Griffey, Brenda F. Baker, Eric E. Swayze
  • Base-modified nucleotides and cleavage of polynucleotides incorporating them
    Patent number: 6610492
    Abstract: The present invention is directed to novel base-modified nucleotides and methods for their use in the preparation and cleavage of modified polynucleotides.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: August 26, 2003
    Assignee: Variagenics, Inc.
    Inventors: Vincent P. Stanton, Jr., Jia Liu Wolfe, Tomohiko Kawate, Charles Allerson, Gregory L. Verdine