Abstract: The invention provides a method and apparatus for preparation of radiochemicals, such as PET molecular imaging probes, wherein the reaction step or steps that couple the radioactive isotope to an organic or inorganic compound to form a positron-emitting molecular imaging probe are performed in a microfluidic environment.

Abstract: A closure (10) for shielding, and selectively providing access to, the targeting assembly of a particle accelerator of a radioisotope production system. The closure (10) includes at least one, and in one embodiment, first and second doors (44, 46), for selectively covering an opening in the housing of the particle accelerator which provides access to the targeting assembly. A door mounting assembly is also provided for mounting the first and second doors (44, 46) on the housing of the particle accelerator. In one embodiment the door mounting assembly includes a frame (30) for being secured about the opening in the particle accelerator accessing the targeting assembly. Further, in one embodiment the frame (30) and first and second doors (44, 46) are fabricated of copper.

Abstract: An apparatus for containing and cooling enriched water for the production of activated fluorine (18F). A target assembly is fabricated with internal cooling channels having minimal conduction paths and high Reynolds number flows. In one embodiment, the target assembly is fabricated of tantalum, which has superior oxidation resistance over silver. The superior oxidation resistance and increased cooling capacity allows for high beam currents.