Patents by Inventor Charles B. Epstein

Charles B. Epstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid constructs and methods for labeling and detecting nucleosomal DNA modifications
    Patent number: 10479986
    Abstract: Embodiments disclosed herein provide methods for identifying cell-type-specific nucleosomal DNA modifications. The methods leverage nucleosomal DNA barcoding and pool-and-split multiplexing to provide high-throughout, quantitative profiling of nucleosomal DNA states. The methods enable the profiling of multiple nucleosomal DNA marks across different cell types and/or conditions thereby linking quantitative changes in chromatin landscapes to different genotypes and chemical and physical perturbations.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: November 19, 2019
    Assignees: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Charles B. Epstein, Peter Van Galen, Bradley E. Bernstein
  • NUCLEIC ACID CONSTRUCTS AND METHODS FOR LABELING AND DETECTING NUCLEOSOMAL DNA MODIFICATIONS
    Publication number: 20170343539
    Abstract: Embodiments disclosed herein provide methods for identifying cell-type-specific nucleosomal DNA modifications. The methods leverage nucleosomal DNA barcoding and pool-and-split multiplexing to provide high-throughout, quantitative profiling of nucleosomal DNA states.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 30, 2017
    Inventors: Charles B. EPSTEIN, Peter VAN GALEN, Bradley E. BERNSTEIN
  • Mitotic Progression Genes and Methods of Modulating Mitosis
    Publication number: 20090215876
    Abstract: The invention features methods of identifying candidate therapeutic compounds for the treatment of proliferative disorder. The invention also features methods for treating a proliferative disorder.
    Type: Application
    Filed: February 14, 2007
    Publication date: August 27, 2009
    Inventors: Randall W. King, Susan K. Lyman, Eunah Chung, Sridaran Natesan, Charles B. Epstein