Patents by Inventor Charles Bernard

Charles Bernard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 12583821
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: January 24, 2024
    Date of Patent: March 24, 2026
    Assignee: CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven M. Mennen, Jacqueline C. S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20250243163
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: December 20, 2024
    Publication date: July 31, 2025
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven MENNEN, Jacqueline C.S. WOO, Bradley Paul MORGAN, Alex MUCI
  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 12221417
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: November 27, 2023
    Date of Patent: February 11, 2025
    Assignee: CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C. S. Woo
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20240317687
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: January 24, 2024
    Publication date: September 26, 2024
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven M. MENNEN, Jacqueline C.S. WOO, Bradley Paul MORGAN, Alex MUCI (Deceased)
  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 11958809
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: April 16, 2024
    Assignee: CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven M. Mennen, Jacqueline C. S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20240101517
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: November 27, 2023
    Publication date: March 28, 2024
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven MENNEN, Jacqueline C.S. WOO, Bradley Paul MORGAN, Alex MUCI (DECEASED)
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20230044617
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: September 8, 2022
    Publication date: February 9, 2023
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven MENNEN, Jacqueline C.S. WOO, Bradley Paul MORGAN, Alex MUCI
  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 11472773
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: October 18, 2022
    Assignee: CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C. S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20220153700
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: September 24, 2021
    Publication date: May 19, 2022
    Inventors: Sheng CUI, Henry MORRISON, Karthik NAGAPUDI, Shawn D. WALKER, Charles BERNARD, Karl Bennett HANSEN, Neil Fred LANGILLE, Alan Martin ALLGEIER, Steven M. MENNEN, Jacqueline C.S WOO, Bradley Paul MORGAN, Alex MUCI
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20200399221
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: July 2, 2020
    Publication date: December 24, 2020
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C.S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20200331859
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: July 2, 2020
    Publication date: October 22, 2020
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C.S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20200079736
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: November 14, 2019
    Publication date: March 12, 2020
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C.S. Woo, Bradley Paul Morgan, Alex Muci
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20180312469
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: April 26, 2018
    Publication date: November 1, 2018
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline Woo, Bradley Paul Morgan, Alex Muci
  • Salt of omecamtiv mecarbil and process for preparing salt
    Patent number: 9988354
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 5, 2018
    Assignee: AMGEN INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline Woo
  • SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
    Publication number: 20160016906
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 21, 2016
    Applicants: AMGEN INC., CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline Woo, Bradley Paul Morgan, Alex Muci
  • Process for making substituted 2-amino-thiazolones
    Patent number: 8541593
    Abstract: The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: September 24, 2013
    Assignee: Amgen Inc.
    Inventors: George A. Moniz, Matthew J. Frizzle, Charles Bernard, Michael Martinelli, Margaret M. Faul, Roger Nani, Jay Larrow
  • Process for making substituted 2-amino-thiazolones
    Patent number: 8536345
    Abstract: The present invention relates to methods of making compounds that inhibit 11-?-hydroxysteroid dehydrogenase type 1 enzyme (11-? HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R1, R2, and R3 are defined herein.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: September 17, 2013
    Assignee: Amgen Inc.
    Inventors: George A. Moniz, Matthew J. Frizzle, Charles Bernard, Michael Martinelli, Margaret Faul, Jay Larrow, Karl B. Hansen, Liane Klingensmith
  • Methods of synthesizing cinacalcet and salts thereof
    Patent number: 8183415
    Abstract: Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: May 22, 2012
    Assignee: Amgen, Inc.
    Inventors: Oliver Thiel, Charles Bernard, Robert Larsen, Michael John Martinelli, Masooma Tamim Raza
  • METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF
    Publication number: 20110281954
    Abstract: Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods.
    Type: Application
    Filed: May 17, 2011
    Publication date: November 17, 2011
    Inventors: Oliver Thiel, Charles Bernard, Robert Larsen, Michael John Martinelli, Masooma Tamim Raza
  • PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES
    Publication number: 20110160463
    Abstract: The present invention relates to methods of making compounds that inhibit 11-?-hydroxysteroid dehydrogenase type 1 enzyme (11-? HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R1, R2, and R3 are defined herein.
    Type: Application
    Filed: June 16, 2009
    Publication date: June 30, 2011
    Inventors: George A. Moniz, Matthew J. Frizzle, Charles Bernard, Michael Martinelli, Margaret Faul, Jay Larrow, Karl B. Hansen, Liane Klingensmith