Patents by Inventor Charles C. Caldwell

Charles C. Caldwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RED BLOOD CELL STORAGE SOLUTIONS, SOLUTION ADDITIVES, AND METHODS FOR IMPROVING THE STORAGE OF RED BLOOD CELLS
    Publication number: 20210235686
    Abstract: Methods, additive kits and storage compositions for decreasing the deleterious effects of storage on pRBCs, for improving the aging process of stored pRBCs, and for preventing or ameliorating patient comorbidities following the transfusion or infusion of stored blood based on inhibiting acid sphingomyelinase during storage are provided.
    Type: Application
    Filed: March 25, 2021
    Publication date: August 5, 2021
    Inventors: Richard S. Hoehn, Peter L. Jernigan, Alex L. Chang, Charles C. Caldwell, Alex Lentsch, Michael J. Edwards, Erich Gulbins, Timothy A. Pritts
  • Diagnostic assays and methods of treating pneumonia, sepsis and systemic inflammatory response syndrome
    Patent number: 10598662
    Abstract: An in vitro method for diagnosing and treating sepsis in a patient is provided, the method including: contacting at least a portion of a biological sample from the patient consisting essentially of microparticles isolated via differential centrifugation with reagents for detection and/or quantification of neutrophil-derived microparticles; determining a level of neutrophil-derived microparticles based on the contacting step; diagnosing sepsis in the patient when the determined level of neutrophil-derived microparticles is elevated relative to a cutoff value of the neutrophil-derived microparticles; and treating the diagnosed patient for sepsis.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: March 24, 2020
    Assignee: University of Cincinnati
    Inventors: Charles C. Caldwell, Kevin R. Kasten, Priya S. Prakash, Bobby L. Johnson, III
  • Diagnostic Assays and Methods of Treating Pneumonia, Sepsis and Systemic Inflammatory Response Syndrome
    Publication number: 20190056397
    Abstract: Methods for assessing pneumonia in a patient, methods for managing treatment of a patient suspected of having pneumonia, and methods of managing treatment in a patient suffering from pneumonia. The method of assessing pneumonia includes contacting a biological sample with reagents for detection and/or quantification of neutrophil-derived microparticles, determining a level of neutrophil-derived microparticles, and assessing pneumonia if the level is elevated. The method of managing treatment of a patient suspected of having pneumonia includes assessing pneumonia by calculating a concentration of neutrophil-derived microparticles, treating the patient where pneumonia is indicated, and determining treatment response by measuring a post treatment concentration of neutrophil-derived microparticles.
    Type: Application
    Filed: July 31, 2018
    Publication date: February 21, 2019
    Inventors: Charles C. Caldwell, Kevin R. Kasten, Priya S. Prakash, Bobby L. Johnson, III
  • Diagnostic assays and methods of treating pneumonia, sepsis and systemic inflammatory response syndrome
    Patent number: 10073097
    Abstract: Methods for assessing pneumonia in a patient, methods for managing treatment of a patient suspected of having pneumonia, and methods of managing treatment in a patient suffering from pneumonia. The method of assessing pneumonia includes contacting a biological sample with reagents for detection and/or quantification of neutrophil-derived microparticles, determining a level of neutrophil-derived microparticles, and assessing pneumonia if the level is elevated. The method of managing treatment of a patient suspected of having pneumonia includes assessing pneumonia by calculating a concentration of neutrophil-derived microparticles, treating the patient where pneumonia is indicated, and determining treatment response by measuring a post treatment concentration of neutrophil-derived microparticles.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 11, 2018
    Inventors: Charles C. Caldwell, Kevin R. Kasten, Priya S. Prakash, Bobby L Johnson, III
  • RED BLOOD CELL STORAGE SOLUTIONS, SOLUTION ADDITIVES, AND METHODS FOR IMPROVING THE STORAGE OF RED BLOOD CELLS
    Publication number: 20170295776
    Abstract: Methods, additive kits and storage compositions for decreasing the deleterious effects of storage on pRBCs, for improving the aging process of stored pRBCs, and for preventing or ameliorating patient comorbidities following the transfusion or infusion of stored blood based on inhibiting acid sphingomyelinase during storage are provided.
    Type: Application
    Filed: April 18, 2017
    Publication date: October 19, 2017
    Inventors: Richard S. Hoehn, Peter L. Jernigan, Alex L. Chang, Charles C. Caldwell, Alex Lentsch, Michael J. Edwards, Erich Gulbins, Timothy A. Pritts
  • Diagnostic Assays and Methods of Treating Pneumonia, Sepsis and Systemic Inflammatory Response Syndrome
    Publication number: 20140148402
    Abstract: Methods for assessing pneumonia in a patient, methods for managing treatment of a patient suspected of having pneumonia, and methods of managing treatment in a patient suffering from pneumonia. The method of assessing pneumonia includes contacting a biological sample with reagents for detection and/or quantification of neutrophil-derived microparticles, determining a level of neutrophil-derived microparticles, and assessing pneumonia if the level is elevated. The method of managing treatment of a patient suspected of having pneumonia includes assessing pneumonia by calculating a concentration of neutrophil-derived microparticles, treating the patient where pneumonia is indicated, and determining treatment response by measuring a post treatment concentration of neutrophil-derived microparticles.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 29, 2014
    Applicant: University of Cincinnati
    Inventors: Charles C. Caldwell, Kevin R. Kasten, Priya S. Prakash, Bobby L. Johnson, III