Patents by Inventor Charles C. Ditlow

Charles C. Ditlow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sol capture immunoassay kit and procedure
    Patent number: 6083760
    Abstract: An immunoassay procedure for detection of analytes in urine wherein an immunological reaction is conducted in an aqueous phase containing the urine and a filterable immunocomposite containing an inherently colored gold sol particle is formed if the assay is positive. The colored, gold sol particle containing immunocomposite is collected for direct visual observation on a filter element.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: July 4, 2000
    Assignee: Hygeia Sciences, Inc.
    Inventors: Charles C. Ditlow, L. Edward Cannon, Francis X. Cole, Gene A. Davis, Eric C. Sigillo, Alicia G. Danti
  • Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
    Patent number: 5955584
    Abstract: The subject invention provides a naturally occurring antigen indicative of the presence of atherosclerotic plaque. The subject invention provides a murine-human chimeric monoclonal antibody which specifically binds to an antigen indicative of the presence of atherosclerotic plaque; and methods and reagents involving the use of the murine-human chimeric monoclonal antibody. The subject invention provides a CDR-grafted antibody; and methods and reagents involving the use of the CDR-grafted antibody. The subject invention provides a surrogate antigen; methods and reagents involving the use of the surrogate antigen, preparation of the surrogate antigen, antibodies generated from the surrogate antigen.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: September 21, 1999
    Assignee: Charter Ventures
    Inventors: Charles C. Ditlow, Francis W. Chen, Emanuel Calenoff
  • Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
    Patent number: 5811248
    Abstract: An antigen comprising 5,7 cholestadien-3.beta.-ol (7-dehydrocholesterol) or a compound having a structure similar to 5,7 cholestadien-3.beta.-ol and a quaternary ammonium salt is provided. Also provided is a method of generating an antibody using the aforementioned antigen, as well as antibodies produced thereby and fragments of such antibodies. The invention also provides a rat myeloma cell line Z2D3 73/30 1D10 and a murine-human chimeric monoclonal antibody produced thereby. A CDR-grafted antibody comprising a CDR region amino acid sequence from hybridoma Z2D3 or hybridoma Z2D3/3E5 and framework and constant region amino acid sequences from a human immunoglobulin is further provided. Also provided are methods for imaging atherosclerotic plaque, ablating atherosclerotic plaque, detecting and quantitatively determining in a sample an antigen indicative of the presence of atherosclerotic plaque, reducing the amount of atherosclerotic plaque in a blood vessel, and treating atherosclerosis in a subject.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 22, 1998
    Assignee: Charter Ventures
    Inventors: Charles C. Ditlow, Francis W. Chen, Emanuel Calenoff
  • Sol capture immunoassay kit and procedure
    Patent number: 5202267
    Abstract: An immunoassay procedure for detection of analytes in urine wherein an immunological reaction is conducted in an aqueous phase containing the urine and a filterable immunocomposite containing an inherently colored gold sol particle is formed if the assay is positive. The colored, gold sol particle containing immunocomposite is collected for direct visual observation on a filter element.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: April 13, 1993
    Assignee: Hygeia Sciences, Inc.
    Inventors: Charles C. Ditlow, L. Edward Cannon, Francis X. Cole, Gene A. Davis, Eric C. Sigillo, Alicia G. Danti