Abstract: Disclosed herein is a conduit embedded with a biocompatible polymer for use in devices such as artificial tissues and organs. Also disclosed are methods of making such conduits.

Abstract: Disclosed are compositions and methods of making basement membrane constructs having interior or luminal volumes. The interior or luminal volumes may be in the form of vascular networks for liquid (e.g., blood) or gas perfusion. The interior spaces may also contain cells, such as epithelial cells. Also disclosed are tissues and organs, and methods of making thereof, comprising basement membrane constructs.

Abstract: Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Abstract: In general, systems, methods, and devices for modeling air leaks in lungs are provided. In an exemplary embodiment, the systems, methods, and devices provide a model to allow for simulation of negative and positive pressure ventilation modes in vitro, which may allow for evaluation and investigation of pathologies and interventions. In addition to ventilation functions the model includes submersion of the lung sample in fluid inside a chamber and cycling the fluid through a collection system to collect air leaked from the lung. The model can allow for quantification and visual observation of air leaks in real time.

Abstract: Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Abstract: Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Abstract: Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Abstract: Disclosed are compositions and methods of making basement membrane constructs having interior or luminal volumes. The interior or luminal volumes may be in the form of vascular networks for liquid (e.g., blood) or gas perfusion. The interior spaces may also contain cells, such as epithelial cells. Also disclosed are tissues and organs, and methods of making thereof, comprising basement membrane constructs.

Abstract: In general, systems, methods, and devices for modeling air leaks in lungs are provided. In an exemplary embodiment, the systems, methods, and devices provide a model to allow for simulation of negative and positive pressure ventilation modes in vitro, which may allow for evaluation and investigation of pathologies and interventions. In addition to ventilation functions the model includes submersion of the lung sample in fluid inside a chamber and cycling the fluid through a collection system to collect air leaked from the lung. The model can allow for quantification and visual observation of air leaks in real time.