Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.

Abstract: A hanger is provided for suspenders of the type having three straps, each strap of the suspender having a pair of stems connected therewith, each stem having a slot extending therethrough for receipt of a garment button. The hanger has an engaging member in an open state for receiving the stem slot and in an engaged state for retaining the slotted end of a stem. A closing member is fixed to the engaging member for automatically closing the engaging member and for maintaining the engaging member in the engaged state. The hanger also has a body portion for connecting the engaging member and the closing member to a support structure so as to hang the suspenders to the support structure. The body portion is capable of allowing the engaging member in either the open state or the engaged state.

Abstract: A method and apparatus is described for providing extended subscriber features, e.g., equal access, to otherwise non-conforming central offices of a telephone switching system. According to the invention, a register module is interposed between the subscriber line and an input of the central office for intercepting digits from the subscriber line intended for the central office and for receiving subscriber information from the central office identifying the subscriber line. The register module includes a memory having a plurality of address locations and a control circuit for analyzing the intercepted digits to determine whether processing of the subscriber call requires an extended subscriber feature. If so, the intercepted digits are processed to generate a coded signal, the coded signal including the address location where the stored digits and the subscriber information resides in the memory.