Patents by Inventor Charles Cantor

Charles Cantor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for performing reactions in an unsealed environment
    Patent number: 6485913
    Abstract: Open systems for performing submicroliter reactions are provided. The systems can include a support for performing the reaction; a liquid dispensing system for dispensing a submicroliter amount of a liquid to a site on or in the support; a temperature controlling device for regulating the temperature of the support; and an interface for controlling the amount of liquid dispensed from the liquid dispensing system are provided. Methods using the systems are also provided.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: November 26, 2002
    Assignee: Sequenom, Inc.
    Inventors: Thomas Becker, Hubert Köster, Charles Cantor
  • Nucleic acid arrays and methods of synthesis
    Publication number: 20020076716
    Abstract: The present invention generally relates to high density nucleic acid arrays and methods of synthesizing nucleic acid sequences on a solid surface. Specifically, the present invention contemplates the use of stabilized nucleic acid primer sequences immobilized on solid surfaces, and circular nucleic acid sequence templates combined with the use of isothermal rolling circle amplification to thereby increase nucleic acid sequence concentrations in a sample or on an array of nucleic acid sequences.
    Type: Application
    Filed: June 21, 2001
    Publication date: June 20, 2002
    Applicant: Trustees of Boston University
    Inventors: Chandran R. Sabanayagam, Takeshi Sano, John Misasi, Anson Hatch, Charles Cantor
  • Multiflavor streptavidin
    Patent number: 6368813
    Abstract: Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create amino acid substitutions resulting in greater affinity for biotin substitutes than for biotin.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: April 9, 2002
    Assignee: The Trustees of Boston University
    Inventors: Gabriel O. Reznik, Takeshi Sano, Sandor Vajda, Cassandra Smith, Charles Cantor
  • Nucleic acid arrays and methods of synthesis
    Patent number: 6284497
    Abstract: The present invention generally relates to high density nucleic acid arrays and methods of synthesizing nucleic acid sequences on a solid surface. Specifically, the present invention contemplates the use of stabilized nucleic acid primer sequences immobilized on solid surfaces, and circular nucleic acid sequence templates combined with the use of isothermal rolling circle amplification to thereby increase nucleic acid sequence concentrations in a sample or on an array of nucleic acid sequences.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: September 4, 2001
    Assignee: Trustees of Boston University
    Inventors: Chandran R. Sabanayagam, Takeshi Sano, John Misasi, Anson Hatch, Charles Cantor
  • Mass spectrometric methods for sequencing nucleic acids
    Patent number: 6268131
    Abstract: A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts obtained by base-specific chain termination. These are analyzed by mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: July 31, 2001
    Assignee: Sequenom, Inc.
    Inventors: Changwon Kang, Young-Soo Kwon, Young Tae Kim, Hubert Köster, Daniel P. Little, Maryanne J. Little, Guobing Xiang, David M. Lough, Charles Cantor
  • Systems and methods for performing reactions in an unsealed environment
    Patent number: 6225061
    Abstract: An open system is provided for performing a submicroliter reaction. An open system can contain a solid support having a target site for performing the reaction; a liquid dispensing system such as a nanoliter dispensing pipette for dispensing a submicroliter amount of a liquid to the target site; a temperature controlling device for regulating the temperature of the support; and means for controlling the amount of liquid dispensed, which corresponds to the amount of liquid that evaporates from the target site. Also provided is an open system, including a solid support having a target site; a liquid dispensing system, which can dispense a liquid to the target site; a temperature controlling system, which regulates the temperature of the solid support; and an interface, which regulates an amount of liquid dispensed from the liquid dispensing system.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: May 1, 2001
    Assignee: Sequenom, Inc.
    Inventors: Thomas Becker, Hubert Köster, Charles Cantor