Abstract: Compound of Formula (I)-(V), compositions comprising at least one compound chosen from compounds of Formula (I)-(V), and methods of using the same, including in treatment of Alzheimer's disease.

Abstract: Systems and methods for generating a coherent matterwave beam are provided. In some aspects, a system includes a plurality of beam generating units. Each of the plurality of beam generating units is configured to generate a stream of charged particles. The system also includes a magnetic field generator configured to expose the plurality of streams to a magnetic field such that (i) the charged particles of the plurality of streams undergo phase synchronization with one another in response to a vector potential associated with the magnetic field and (ii) the plurality of streams is directed along one or more channels to combine with one another and produce a coherent matterwave beam.

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

Abstract: A power-generating device is disclosed that includes a pyroelectric material having first and second surfaces on opposite sides of the pyroelectric material. The device also includes a first conductive electrode coupled to a first support element that is configured to intermittently bring the first electrode into proximity with the first surface and a second conductive electrode proximate to the second surface at least while the first electrode is proximate to the first surface. The device also includes a power module that is electrically coupled between the first and second electrodes. The power module is configured to capture power from an electrical current flowing between the first and second electrodes.

Abstract: Systems and methods for generating a coherent matterwave beam are provided. In some aspects, a system includes a plurality of beam generating units. Each of the plurality of beam generating units is configured to generate a stream of charged particles. The system also includes a magnetic field generator configured to expose the plurality of streams to a magnetic field such that (i) the charged particles of the plurality of streams undergo phase synchronization with one another in response to a vector potential associated with the magnetic field and (ii) the plurality of streams is directed along one or more channels to combine with one another and produce a coherent matterwave beam.

Abstract: An Aharonov-Bohm (AB) sensor is provided. The AB sensor includes a beam splitter configured to split a first electron beam into a first wave and a second wave. The beam splitter is configured to direct the first wave along a first path through a field-free cage. A phase of the first wave is configured to shift in response to a vector potential of a signal. The vector potential is present within the field-free cage. The AB sensor includes a beam combiner configured to combine the phase shifted first wave with the second wave to generate a second electron beam, which is modulated based on the phase shift of the first wave. The AB sensor includes a detector configured to receive the second electron beam and to detect the signal based on the modulation of the second electron beam.

Abstract: An Aharonov-Bohm (AB) sensor is provided. The AB sensor includes a beam splitter configured to split a first electron beam into a first wave and a second wave. The beam splitter is configured to direct the first wave along a first path through a field-free cage. A phase of the first wave is configured to shift in response to a vector potential of a signal. The vector potential is present within the field-free cage. The AB sensor includes a beam combiner configured to combine the phase shifted first wave with the second wave to generate a second electron beam, which is modulated based on the phase shift of the first wave. The AB sensor includes a detector configured to receive the second electron beam and to detect the signal based on the modulation of the second electron beam.

Abstract: A power-generating device is disclosed that includes a pyroelectric material having first and second surfaces on opposite sides of the pyroelectric material. The device also includes a first conductive electrode coupled to a first support element that is configured to intermittently bring the first electrode into proximity with the first surface and a second conductive electrode proximate to the second surface at least while the first electrode is proximate to the first surface. The device also includes a power module that is electrically coupled between the first and second electrodes. The power module is configured to capture power from an electrical current flowing between the first and second electrodes.

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

Abstract: A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A retractable sheath may be disposed around the distal section of the needle to protect the needle when not in use. The sheath retracts when the probe is inserted into tissue and the position of the sheath relative to the needle may be measured to determine the needle's depth. Systems and methods for tissue identification are also provided.

Abstract: A method of forming a concrete block embedded with coquina stone comprising the steps of positioning a layer of sand on the bottom surface of a concrete block form, then positioning a layer of coquina stone above the layer of sand positioned on the bottom surface, then pouring concrete over the layer of sand and the layer of coquina stone, thereafter allowing the concrete to harden to form a concrete block which is then removed from the concrete block form.

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

Abstract: A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A retractable sheath may be disposed around the distal section of the needle to protect the needle when not in use. The sheath retracts when the probe is inserted into tissue and the position of the sheath relative to the needle may be measured to determine the needle's depth. Systems and methods for tissue identification are also provided.

Abstract: The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).

Abstract: A plasma jet system includes a housing with a single opening. A plasma generator is coupled to ionize a fluid in the housing. An electromagnetic accelerator is coupled to generate an electric field that accelerates ionized fluid in the housing toward the opening. A controller can modulate the frequency of the electric field to cause the ionized fluid to form a plasma vortex flow through the opening. A magnetic field is applied normal to the direction of the plasma vortex flow to mitigate the momentum of the electrons. The electrons slowed by the magnetic field can be collected and conducted to a location where they are re-inserted into the plasma vortex flow to maintain charge neutrality.

Abstract: A surveillance system is provided for surveillance of objects within a secure area. A surveillance sensor transmits surveillance signals to all objects within the secure area, the reflections of which are received back by the surveillance sensor to determine the locations of objects, and communicates the determined locations to a pressing facility. Objects authorized to be in the secure area are equipped with an Identification Friend or Foe (IFF) unit that includes a GPS receiver and a data communication transmitter. In response to predetermined conditions, the IFF units broadcast their position and identification to the processing facility for correlation with locations defined by the reflection signals.

Abstract: The microstructure non-thermal visible light source may emit visible light. A microstructure element may be filled with a gas and may be disposed in a light transparent dielectric binder positioned between two spaced apart electrical conductors. An electrical source may be in electrical communication with the electrical conductors for the electrical source to transmit a signal to the electrical conductors to excite the gas to cause an electron in a plurality of gas molecules to transition to higher energy states. The higher energy states may be metastable and the higher energy states may decay with the emission of a photon at selected wavelengths.

Abstract: A tissue guidance system integrates an ultrasound imaging device with a tissue diagnostic probe. Ultrasound imaging is used to guide the tissue probe to the target area. Measurements made by the probe can then be analyzed to determine tissue type or state (e.g., malignant or benign).