Abstract: The disclosed computer-implemented method may include instant and optimized matching of transportation requesters with transportation providers by precomputing and caching evaluations of matching schemes between existing requests and available providers, where each of the matching schemes excludes one of the available providers. The possibility of matching any new request to a given provider may then be evaluated according to the cached results of the matching scheme that excluded that provider along with an evaluation of matching the new request to the provider, which may be a computationally easy problem. Thus, the new request may be matched to a provider instantly without waiting for the next iteration of solving the global matching problem. Matching requestors and providers in this way may also improve the accuracy of estimated time of arrival information provided to requestors. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A two-step door opening mechanism for an oven is provided. The mechanism includes first and second buttons, arranged side-by-side on a front panel of the oven, the oven defining an oven cavity openable and closable by an oven door, the first and second buttons being separately actuatable one after the other for providing two distinct actions to be performed to open the oven door. The first button, once actuated, is operable to unlock the second button, and the second button, once actuated, is operable to open the door when the second button is unlocked.

Abstract: Quantum dots and methods of making quantum dots are described. A method begins with forming quantum dots having a core-shell structure with a plurality of ligands on the shell structure. The method includes exchanging the plurality of ligands with a plurality of second ligands. The plurality of second ligands have a weaker binding affinity to the shell structure than the plurality of first ligands. The plurality of second ligands are then exchanged with hydrolyzed alkoxysilane to form a monolayer of hydrolyzed alkoxysilane on a surface of the shell structure. The method includes forming a barrier layer around the shell structure by using the hydrolyzed alkoxysilane as a nucleation center.

Abstract: The present invention relates to methods for improvement in lower urinary tract function in an individual with neurogenic urological dysfunction through epidural stimulation of the spinal cord. In certain embodiments, the methods comprise applying a pattern of epidural electrical stimulation to the spinal cord of an individual with impaired lower urinary tract under stimulation parameters sufficient to improve the storage of fluid in the bladder, sensations of fullness and/or emptying, detrusor over-activity, high detrusor pressure, voiding the bladder, transitioning from a storage state to a voiding state, and decreasing detrusor-external urethral sphincter dyssynergia. In certain embodiments, additional patterns of epidural electrical stimulation may be applied simultaneously, such as to maintain a normotensive cardiovascular state of the individual.

Abstract: A calendar UI is provided showing on one side a calendar of events in day of the month format and on the other side a column of tiles, each corresponding to an event on the calendar and selectable to invoke a web page to play a game or purchase a product or hot launch the user into a game.

Abstract: Provided is an isochroman compound represented by formula (I), or a pharmaceutically acceptable salt thereof, which is used as an aldo-keto reductase (AKR1C3) inhibitor for the treatment of liver cancer.

Abstract: Disclosed is a type of indolo heptamyl oxime analog crystalline form as a PARP inhibitor and a method for preparing the same, specifically relating to a crystalline form of a compound of formula (I) and a method for preparing the same.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for encoding video comprising a sequence of video frames. In one aspect, a method comprises for one or more of the video frames: obtaining a feature embedding for the video frame; processing the feature embedding using a rate control machine learning model to generate a respective score for each of multiple quantization parameter values; selecting a quantization parameter value using the scores; determining a cumulative amount of data required to represent: (i) an encoded representation of the video frame and (ii) encoded representations of each preceding video frame; determining, based on the cumulative amount of data, that a feedback control criterion for the video frame is satisfied; updating the selected quantization parameter value; and processing the video frame using an encoding model to generate the encoded representation of the video frame.

Abstract: Disclosed are a crystalline form of a Toll-like receptor 8 (TLR8) agonist as represented by formula (I) and a preparation method therefor. Further provided is an application of the crystalline form in the preparation of a drug for treating a disease responsive to the TLR8 agonist.

Abstract: The present disclosure includes in one instance an optical article comprising a data rich plurality of retroreflective elements that are configured in a spatially defined arrangement, where the plurality of retroreflective elements comprise retroreflective elements having at least two different retroreflective properties, and where data rich means information that is readily machine interpretable. The present disclosure also includes a system comprising the previously mentioned optical article, an optical system, and an inference engine for interpreting and classifying the plurality of retroreflective elements wherein the optical system feeds data to the inference engine.

Abstract: A pyrimidine ring compound represented by formula (III), or a pharmaceutically acceptable salt thereof, and an application thereof in preparation of a medication for treating related diseases.

Abstract: Computer-implemented systems and methods for providing contextual game guidance are described herein. An example method includes determining based on contextual information regarding an application an objective of the user; automatically deriving based on the contextual information and the objective contextual guidance to assist the user; generating a user interface having the contextual guidance; and transmitting the user interface to a client device.

Abstract: A method includes generating, using an audio encoder, a higher-order feature representation for each acoustic frame in a sequence of acoustic frames; generating, using a decoder, based on the higher-order feature representation, a plurality of speech recognition hypotheses, each hypotheses corresponding to a candidate transcription of an utterance and having an associated first likelihood score; generating, using an external language model, for each speech recognition hypothesis, a second likelihood score; determining, using a learnable fusion module, for each speech recognition hypothesis, a set of fusion weights based on the higher-order feature representation and the speech recognition hypothesis; and generating, using the learnable fusion module, for each speech recognition hypothesis, a third likelihood score based on the first likelihood score, the second likelihood score, and the set of fusion weights, the audio encoder and decoder trained using minimum additive error rate training in the presence of t

Abstract: In various examples, methods and systems are provided for estimating depth values for images (e.g., from a monocular sequence). Disclosed approaches may define a search space of potential pixel matches between two images using one or more depth hypothesis planes based at least on a camera pose associated with one or more cameras used to generate the images. A machine learning model(s) may use this search space to predict likelihoods of correspondence between one or more pixels in the images. The predicted likelihoods may be used to compute depth values for one or more of the images. The predicted depth values may be transmitted and used by a machine to perform one or more operations.

Abstract: The present disclosure provides methods of treating lung disease subjects that are likely to respond to an IL-33 antagonist, an interleukin-4 receptor alpha antagonist, or an IL-13 receptor antagonist, based on the subject's IL-33 Asthma polygenic risk score.

Abstract: Identifying an attack surface of a cloud deployment, including: identifying a security threat of a cloud deployment; gathering, from one or more components in a software development pipeline, information associated with the cloud deployment; identifying, based on the information associated with the cloud deployment, a portion of code enabling the security threat; and generating the alert based on the security threat and the identified portion of code.

Abstract: The present disclosure provides methods of identifying subjects having a lung disease or at risk of developing a lung disease that will respond favorably to treatment with a therapeutic agent that treats or inhibits a lung disease, such as dupilumab, an inhaled corticosteroid (ICS), or a long-acting beta agonist (LABA), and methods of treating a subject having a lung disease with a therapeutic agent that treats or inhibits a lung disease, such as dupilumab, an ICS, or a LABA, and determining or having determined the subject's FEV1 polygenic score (FEV1-PS).

Abstract: A system installed in a vehicle includes a first group of sensing devices configured to allow a first level of autonomous operation of the vehicle; a second group of sensing devices configured to allow a second level of autonomous operation of the vehicle, the second group of sensing devices including primary sensing devices and backup sensing devices; a third group of sensing devices configured to allow the vehicle to perform a safe stop maneuver; and a control element communicatively coupled to the first group of sensing devices, the second group of sensing devices, and the third group of sensing devices. The control element is configured to: receive data from at least one of the first group, the second group, or the third group of sensing devices, and provide a control signal to a sensing device based on categorization information indicating a group to which the sensing device belongs.

Abstract: A quinazoline compound and a pharmaceutically acceptable salt thereof, in particular a compound of formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: An apparatus and a method for managing network flow congestion are provided. The method for managing network flow congestion includes: receiving a plurality of packets; identifying whether each packet belongs to a predetermined protocol; distinguishing a plurality of connections of the packets belonged to the predetermined protocol; monitoring a buffer usage of each different connections; and performing a congestion check procedure on the currently monitored connection. In the congestion check procedure, when the buffer usage of the currently monitored connection exceeds a threshold, a congestion processing procedure is triggered.