Patents by Inventor Charles D Amsler

Charles D Amsler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MRSA biofilm inhibition
    Patent number: 11213507
    Abstract: Provided is a darwinolide compound having a previously undescribed carbon skeleton and the crystalline form thereof. Also provided are processes of isolating darwinolide, compositions comprising darwinolide, and methods of treating infection, such as a methicillin-resistant Staphylococcus aureus biofilm infection.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: January 4, 2022
    Assignees: UNIVERSITY OF SOUTH FLORIDA, UAB RESEARCH FOUNDATION
    Inventors: Bill J. Baker, Lindsey N. Shaw, James Bruce McClintock, Charles D. Amsler, Jacqueline Lee Fries, Witowski G. Christopher, Renee M. Fleeman
  • MRSA BIOFILM INHIBITION
    Publication number: 20210205266
    Abstract: Provided is a darwinolide compound having a previously undescribed carbon skeleton and the crystalline form thereof. Also provided are processes of isolating darwinolide, compositions comprising darwinolide, and methods of treating infection, such as a methicillin-resistant Staphylococcus aureus biofilm infection.
    Type: Application
    Filed: April 17, 2017
    Publication date: July 8, 2021
    Inventors: Bill J. Baker, Lindsey N. Shaw, James Bruce McClintock, Charles D. Amsler, Jacqueline Lee Fries, Witowski G. Christopher, Renee M. Fleeman
  • Cytotoxin compounds and methods of isolation
    Patent number: 10815212
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 27, 2020
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UAB RESEARCH FOUNDATION
    Inventors: Bill J. Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler
  • CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION
    Publication number: 20190359584
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Application
    Filed: June 23, 2016
    Publication date: November 28, 2019
    Inventors: BILL J. BAKER, THUSHARA DIYABALANAGE, JAMES B. MCCLINTOCK, CHARLES D. AMSLER
  • CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION
    Publication number: 20160297790
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Application
    Filed: June 23, 2016
    Publication date: October 13, 2016
    Inventors: BILL J. BAKER, THUSHARA DIYABALANAGE, JAMES B. MCCLINTOCK, CHARLES D. AMSLER
  • Cytotoxin compounds and methods of isolation
    Patent number: 9394270
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: July 19, 2016
    Assignees: UNIVERSITY OF SOUTH FLORIDA, UAB RESEARCH FOUNDATION
    Inventors: Bill J. Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler
  • NOVEL ANTIVIRAL COMPOUNDS FROM MARINE EXTRACTS
    Publication number: 20140274883
    Abstract: The subject invention pertains to novel biologically active extracts from marine algae and to biologically active fractions and components of these extracts. These extracts have been shown to possess antiviral properties. Pharmaceutical compositions comprising these extracts, or comprising biologically active fractions or components of these extracts, could be used in the treatment of viral diseases including influenza.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 18, 2014
    Applicants: UAB RESEARCH FOUNDATION, UNIVERSITY OF SOUTH FLORIDA
    Inventors: Alberto VAN OLPHEN, Bill J. BAKER, Dennis E. KYLE, Cynthia BUCHER, Alan MASCHEK, James B. MCCLINTOCK, JR., Charles D. AMSLER
  • CYTOTOXIN COMPOUNDS AND METHODS OF ISOLATION
    Publication number: 20140194495
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Application
    Filed: March 11, 2014
    Publication date: July 10, 2014
    Applicants: THE UAB RESEARCH FOUNDATION, UNIVERSITY OF SOUTH FLORIDA
    Inventors: BILL J. BAKER, THUSHARA DIYABALANAGE, JAMES B. MCCLINTOCK, CHARLES D. AMSLER
  • Cytotoxin compounds and methods of isolation
    Patent number: 8669376
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: March 11, 2014
    Assignees: University of South Florida, The UAB Research Foundation
    Inventors: Bill Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler
  • NOVEL ANTIVIRAL COMPOUNDS FROM MARINE EXTRACTS
    Publication number: 20110189221
    Abstract: The subject invention pertains to novel biologically active extracts from marine algae and to biologically active fractions and components of these extracts. These extracts have been shown to possess antiviral properties. Pharmaceutical compositions comprising these extracts, or comprising biologically active fractions or components of these extracts, could be used in the treatment of viral diseases including influenza.
    Type: Application
    Filed: January 14, 2011
    Publication date: August 4, 2011
    Inventors: Alberto van Olphen, Bill J. Baker, Dennis E. Kyle, Cynthia Bucher, Alan Maschek, James B. McClintock, JR., Charles D. Amsler
  • Cytotoxin Compound And Method of Isolation
    Publication number: 20100063137
    Abstract: The present invention concerns compounds derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds and methods of use. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Application
    Filed: November 13, 2009
    Publication date: March 11, 2010
    Applicants: University of South Florida, The UAB Research Foundation
    Inventors: Bill J. Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler
  • Cytotoxin compound and method of isolation
    Patent number: 7625885
    Abstract: A compound or groups of compounds, present in an active principle, derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: December 1, 2009
    Assignees: University of South Florida, The UAB Research Foundation
    Inventors: Bill J Baker, Thusahara Diyabalanage, James B McClintock, Charles D Amsler
  • Cytotoxin Compounds and Methods of Isolation
    Publication number: 20090192215
    Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
    Type: Application
    Filed: September 18, 2006
    Publication date: July 30, 2009
    Applicants: University of South Florida, UAB Research Foundation
    Inventors: Bill Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler